Gene/Proteome Database (LMPD)

LMPD ID
LMP011501
Gene ID
64617
Species
Danio rerio (Zebrafish)
Gene Name
sphingosine-1-phosphate receptor 1
Gene Symbol
s1pr1
Synonyms
edg1; wu:fb98f05
Chromosome
22

Proteins

sphingosine 1-phosphate receptor 1
Refseq ID NP_571766
Protein GI 50355954
UniProt ID Q9DDK4
mRNA ID NM_131691
Length 362
RefSeq Status PROVISIONAL
MDDLIARHYNFTGKFRKVHKDPGLKADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSMNNCSTVLPLYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAFIKMLNCGVCVQPSGKFSRPIMGAEFSRSKSDNSSHPNKDEPEYSPRETIVSSGNITSSS

Gene Information

Entrez Gene ID
64617
Gene Name
sphingosine-1-phosphate receptor 1
Gene Symbol
s1pr1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IC:UniProtKB C integral component of membrane
GO:0031226 ISS:UniProtKB C intrinsic component of plasma membrane
GO:0038036 ISS:UniProtKB F sphingosine-1-phosphate receptor activity
GO:0007186 IDA:UniProtKB P G-protein coupled receptor signaling pathway
GO:0042074 IMP:ZFIN P cell migration involved in gastrulation
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0008078 IGI:ZFIN P mesodermal cell migration
GO:0030335 IMP:ZFIN P positive regulation of cell migration
GO:0003376 ISS:UniProtKB P sphingosine-1-phosphate signaling pathway
GO:0001944 IMP:ZFIN P vasculature development

Domain Information

InterPro Annotations

Accession Description
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 1
Protein Entry
Q9DDK4_DANRE
UniProt ID
Q9DDK4
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage Embryonic brain. Not detected during blastula or gastrula stages. At the 4-5 somite stage, expressed in the diencephalon just posterior to the optic vesicles, and weakly in the hindbrain. By the 14 somite stage, there is widespread expression in the CNS, particularly in the ventral diencephalon, optic stalks and anterior hindbrain.
Function G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate.
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP011501 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50355954 RefSeq NP_571766 362 sphingosine 1-phosphate receptor 1

Identical Sequences to LMP011501 proteins

Reference Database Accession Length Protein Name
GI:50355954 GenBank AAH75741.1 362 Sphingosine-1-phosphate receptor 1 [Danio rerio]
GI:50355954 SwissProt Q9DDK4.2 362 RecName: Full=Sphingosine 1-phosphate receptor 1; Short=S1P receptor 1; Short=S1P1; AltName: Full=Sphingosine 1-phosphate receptor Edg-1; Short=S1P receptor Edg-1 [Danio rerio]

Related Sequences to LMP011501 proteins

Reference Database Accession Length Protein Name
GI:50355954 EMBL CDQ90261.1 372 unnamed protein product [Oncorhynchus mykiss]
GI:50355954 EMBL CDQ69631.1 372 unnamed protein product [Oncorhynchus mykiss]
GI:50355954 GenBank AAG45430.1 362 sphingosine 1-phosphate receptor [Danio rerio]
GI:50355954 RefSeq XP_004569385.1 376 PREDICTED: sphingosine 1-phosphate receptor 1-like [Maylandia zebra]
GI:50355954 RefSeq XP_007240171.1 368 PREDICTED: sphingosine 1-phosphate receptor 1 [Astyanax mexicanus]
GI:50355954 RefSeq XP_008283575.1 373 PREDICTED: sphingosine 1-phosphate receptor 1 [Stegastes partitus]