Gene/Proteome Database (LMPD)

LMPD ID
LMP011504
Gene ID
81884
Species
Danio rerio (Zebrafish)
Gene Name
nuclear receptor coactivator 2
Gene Symbol
ncoa2
Synonyms
tif2; wu:fc41a10; wu:fe26a11
Chromosome
24

Proteins

nuclear receptor coactivator 2
Refseq ID NP_571852
Protein GI 18859481
UniProt ID Q98TW1
mRNA ID NM_131777
Length 1505
RefSeq Status PROVISIONAL
MSAVGENSSDPARSEAQKRKEGPSDLLGPSPKRSTEKRNREHESKYIEELAELIFANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNMEGNIVFVSENVTQYLRYNQEELMNTSVYSILHVGDHAEFIKNLLPKSHVNGVPWSSENPRRNSHTFNCRMLVNPHSEAEETQDHEAQQKYETMQCFAVSEPKSIKEEGEDFQSCLICVARRVPMKERPMLPTQESFTTRQDLQGKITSLDTSLLRASMKPGWEDLVRRCIQRFHLQNDGDISFAKRHQQEVIRHGQAFSPIYRFSLSDGTIVSAHTKSKLVRSSSTNEPQLYMSLHILQREQPVCGMASDLGNAQTMGKPMNPMSSPNTAGSSCTPQGQDATISSNTSTFPSPGAQKEPGAMHRFGCPGTMSHSATMQAATPQGSGYPLKLSSPSQGSPGMLSPRHRASPGVAGSPRLPPPQFSPAGSLHSPASMCTSSTGGNGGAGANHGYTSSSLNALQALSECHGVSHGQSLGSPDRKLGSPAAHSVAVSHHLINKMSVPESFGEQNQSEQGTPGQDEGIDLPRDEKGNLGQFGNLDGSDPQSRLRDNKSHTKLLQLLTTKTEPIESTSPPPMAGGEPGCKDGGAGNGGMGSQGGNGSHATSLKEKHKILHRLLQNSSSPVDLAKLTAEATGKELCQDSAGGTAGVPELAIKQEPVSPKKKDNALLRYLLDKDDNVLKGKGIKMEPGEIKEEGGKMTGIKTEKTDGGYDRVEPSSELDDILDDLQNSQPGLFTDSRPVSLPSAVDKQSIINDILQMTGESGANMSPQQQRALQTAVSQQNFPAPRPGQPGRAPPVRSVSLDMNMPPKGAQGQYPMMRNNNPYSIMQQQGMMGNHAVMPNQPNMVNAGVMGNNGPRVGMQQDGWGAQGTVGSAASPATAAPAGQHSLPQGALHSRMVPNPATGMPMRPNSQPGPRPMLQPQMMANAQSNMDMGMAGHQFPQQQAPPNQTAPWPDSVMPIEPVPFGNQSSSMYGGSQEDVLCPPASEGPADEGALLSQLYSALKDFDGLEEIDRALGIPALVGQAQPVEQDQFPGQDPSMMMDQKPPMYGQQQYASSPANMQQAGYTPMQDATFHGLQGQMGQRPGYPMLRMQARPGLRPGGVVPNQPNTLRLQLQHRLQAQQNRQPMMNQMGGVSNMNLPLRPNVPNQGTINAQMLAQRQRELLSNHLRQRQLDQQRNNQRSLAMRAQGLTMPPNMAAAAAGMPGAMSNPRIPQANLQQFPYPPNYGTGLASPPPSTSPFSPGSPNLPAPQLLSHSAMHGSQMSLANQGMLGSLSGQFGAVMSPQMQHSAFQFPSSGMSQQSDGGFGGAATPQSPLMSPRMGHAQSPMMQQAQGNSSFQSSPDMNGWPQGNINTNSMFTQQSPPQFSQQANNNMYNGNGMNLNVSMAANSSNMGQMGNQMSMSSMNSGPGSGMANMGPEQQKYC

Gene Information

Entrez Gene ID
81884
Gene Name
nuclear receptor coactivator 2
Gene Symbol
ncoa2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 ISS:UniProtKB C nucleus
GO:0004402 IEA:InterPro F histone acetyltransferase activity
GO:0004871 IEA:InterPro F signal transducer activity
GO:0046966 IPI:UniProtKB F thyroid hormone receptor binding
GO:0030375 ISS:UniProtKB F thyroid hormone receptor coactivator activity
GO:0030851 IMP:UniProtKB P granulocyte differentiation
GO:0030099 IMP:UniProtKB P myeloid cell differentiation
GO:2000273 ISS:GOC P positive regulation of receptor activity
GO:0060215 IMP:UniProtKB P primitive hemopoiesis
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR017426 Nuclear receptor coactivator
IPR028822 Nuclear receptor coactivator 2
IPR008955 Nuclear receptor coactivator Src-1
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR009110 Nuclear receptor coactivator, interlocking
IPR000014 PAS domain
IPR013767 PAS_fold
IPR014935 Steroid receptor coactivator

UniProt Annotations

Entry Information

Gene Name
nuclear receptor coactivator 2
Protein Entry
Q98TW1_DANRE
UniProt ID
Q98TW1
Species
Zebrafish

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=E20a ; IsoId=Q98TW1-1; Sequence=Displayed; Name=E20b ; IsoId=Q98TW1-2; Sequence=VSP_052992;
Domain Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
Domain Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (By similarity).
Domain The LLXXLXXXL domain is involved in transcriptional coactivation and crebbp/cbp binding.
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages.
Similarity Belongs to the SRC/p160 nuclear receptor coactivator family.
Similarity Contains 1 PAS (PER-ARNT-SIM) domain.
Similarity Contains 1 bHLH (basic helix-loop-helix) domain.
Subcellular Location Nucleus .
Subunit Interacts with the thyroid hormone receptors thraa and thrb (via the ligand-binding domain).
Tissue Specificity Expressed ubiquitously in the embryo and in many adult tissues including the brain, gills, liver, swim bladder and skin. Shows highest expression in the ovary and testis, and lower expression in the intestine, eye and skin. Only isoform E20b is expressed in the muscle and heart. {ECO:0000269|PubMed:17997606, ECO:0000269|PubMed:18248177, ECO:0000269|PubMed:18295965}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011504 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18859481 RefSeq NP_571852 1505 nuclear receptor coactivator 2

Identical Sequences to LMP011504 proteins

Reference Database Accession Length Protein Name
GI:18859481 GenBank AAK11608.1 1505 transcriptional intermediary factor 2 [Danio rerio]
GI:18859481 GenBank AAP69780.1 1505 nuclear receptor coactivator [Danio rerio]
GI:18859481 SwissProt Q98TW1.1 1505 RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2; Short=NCoA2; AltName: Full=Glucocorticoid receptor-interacting protein 1; AltName: Full=Steroid receptor coactivator 2; AltName: Full=Transcriptional intermediary factor 2 [Danio rerio]

Related Sequences to LMP011504 proteins

Reference Database Accession Length Protein Name
GI:18859481 GenBank AAI63724.1 1505 Nuclear receptor coactivator 2 [Danio rerio]
GI:18859481 RefSeq XP_007260173.1 1501 PREDICTED: nuclear receptor coactivator 2 isoform X1 [Astyanax mexicanus]
GI:18859481 RefSeq XP_007260174.1 1431 PREDICTED: nuclear receptor coactivator 2 isoform X2 [Astyanax mexicanus]
GI:18859481 RefSeq XP_009295611.1 1505 PREDICTED: nuclear receptor coactivator 2 isoform X1 [Danio rerio]
GI:18859481 RefSeq XP_009295612.1 1504 PREDICTED: nuclear receptor coactivator 2 isoform X2 [Danio rerio]
GI:18859481 RefSeq XP_009295613.1 1435 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Danio rerio]