Gene/Proteome Database (LMPD)

LMPD ID
LMP011513
Gene ID
170457
Species
Danio rerio (Zebrafish)
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
s1pr2
Synonyms
mil; edg5; s1p2
Alternate Names
sphingosine 1-phosphate receptor 2; miles apart; S1P receptor 2; S1P receptor Edg-5; sphingosine 1-phosphate receptor Edg-5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Chromosome
3

Proteins

sphingosine 1-phosphate receptor 2
Refseq ID NP_001153442
Protein GI 229577190
UniProt ID Q9I8K8
mRNA ID NM_001159970
Length 370
RefSeq Status PROVISIONAL
MTTCRLFAGFCQAVTMSKYSQYFNKTLIQVHYLTAKEMTAEELRDRIESKQSLSSLNILFVVICSIIILENLLVLIAVFRNKKFHSAMFFFIGNLAFSDLLAGSAYIANIFLSGPRTFHLTPVQWFIREGTAFIALSASVFSLLAIAIERYIAITKVKVYGSNKTCRMFLLIGACWVMSILLGGLPIIGWNCINNLDDCSAVLPLNTRYYIRFVVTIFSIILLSIVILYVRIYLIVRTSHQEATNSPAYALLKTVTIVLGVFIICWLPAFTILLLDTSCKMKQCPILNNAGIFFSFATLNSALNPLIYTLRSKDMRKEFLRVLCCWGLLNCGRPPHRCMVPLKSSSSMEHCTNKHEHQSIPIMQDCTTCV

Gene Information

Entrez Gene ID
170457
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
s1pr2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0048901 IMP:ZFIN P anterior lateral line neuromast development
GO:0035676 IMP:ZFIN P anterior lateral line neuromast hair cell development
GO:0003319 IMP:ZFIN P cardioblast migration to the midline involved in heart rudiment formation
GO:0042074 IMP:ZFIN P cell migration involved in gastrulation
GO:0060027 IDA:ZFIN P convergent extension involved in gastrulation
GO:0003143 IMP:ZFIN P embryonic heart tube morphogenesis
GO:0048703 IGI:ZFIN P embryonic viscerocranium morphogenesis
GO:0007507 IMP:ZFIN P heart development
GO:0003007 IMP:ZFIN P heart morphogenesis
GO:0008078 IGI:ZFIN P mesodermal cell migration
GO:0030336 IMP:ZFIN P negative regulation of cell migration
GO:0048840 IMP:ZFIN P otolith development
GO:0035677 IMP:ZFIN P posterior lateral line neuromast hair cell development
GO:0061035 IMP:ZFIN P regulation of cartilage development
GO:0060872 IMP:ZFIN P semicircular canal development
GO:0003376 IMP:ZFIN P sphingosine-1-phosphate signaling pathway
GO:0001944 IGI:ZFIN P vasculature development

REACTOME Pathway Links

REACTOME Pathway ID Description
6176487 G alpha (i) signalling events
6176576 Lysosphingolipid and LPA receptors

Domain Information

InterPro Annotations

Accession Description
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR004063 EDG-5 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 2
Protein Entry
S1PR2_DANRE
UniProt ID
Q9I8K8
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage The expression pattern is complex and dynamic. Maternal expression is found in a diffuse pattern throughout the blastoderm, and this pattern persists through the onset of gastrulation. More pronounced expression can be seen at tailbud stage in the anterior portion of the embryo and along the embryonic axis, and at the 16-somite stage in the midbrain/hindbrain boundary and the tip of the tail where blisters later develop in receptor mutants. At the 18-somite stage, expression appears just lateral to the midline, and as the myocardial precursors migrate to the midline, their location overlaps with this domain of receptor expression.
Disease Note=Defects in s1pr2 are a cause of heart development abnormality named miles apart (mil). In all vertebrates, the myocardial progenitors involute early during gastrulation and come to occupy bilateral positions in the anterior lateral plate mesoderm (LPM). During somitogenesis, these cells undergo a second phase of migration toward the midline and fuse to form the definitive heart tube. Defects in S1PR2 disrupt this process, leading to the formation of two laterally positioned hearts (cardia bifida). The mil phenotype for which two recessive alleles exist, mil(m93) and mil(te273) are fully penetrant. Mil(m93)/mil(te273) transheterozygous embryos display the same phenotype as homozygotes for either single mutant allele. In addition to cardia bifida, mil mutants display epithelial tail blisters, indicative of a defect in epithelial integrity.
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P receptor is critical for cell migration and epithlial integrity during vertebrate embryogenesis.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP011513 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
229577190 RefSeq NP_001153442 370 sphingosine 1-phosphate receptor 2

Identical Sequences to LMP011513 proteins

Reference Database Accession Length Protein Name
GI:229577190 GenBank AAF88001.1 370 EDG-5-related protein, partial [Danio rerio]
GI:229577190 SwissProt Q9I8K8.1 370 RecName: Full=Sphingosine 1-phosphate receptor 2; Short=S1P receptor 2; Short=S1P2; AltName: Full=Sphingosine 1-phosphate receptor Edg-5; Short=S1P receptor Edg-5 [Danio rerio]

Related Sequences to LMP011513 proteins

Reference Database Accession Length Protein Name
GI:229577190 EMBL CDQ81096.1 373 unnamed protein product [Oncorhynchus mykiss]
GI:229577190 EMBL CDQ73629.1 373 unnamed protein product [Oncorhynchus mykiss]
GI:229577190 GenBank AHH39430.1 367 Sphingosine 1-phosphate receptor 2 [Ictalurus punctatus]
GI:229577190 RefSeq XP_007241097.1 375 PREDICTED: sphingosine 1-phosphate receptor 2 [Astyanax mexicanus]
GI:229577190 RefSeq XP_008281316.1 371 PREDICTED: sphingosine 1-phosphate receptor 2 [Stegastes partitus]
GI:229577190 RefSeq XP_008327433.1 372 PREDICTED: sphingosine 1-phosphate receptor 2 [Cynoglossus semilaevis]