Gene/Proteome Database (LMPD)

LMPD ID
LMP011524
Gene ID
259252
Species
Danio rerio (Zebrafish)
Gene Name
estrogen receptor 1
Gene Symbol
esr1
Synonyms
ESR; ER[a]; NR3A1; eralpha; zfER[a]
Alternate Names
estrogen receptor; ER; ER-alpha; estradiol receptor; estrogen receptor alpha; nuclear receptor subfamily 3 group A member 1
Chromosome
20

Proteins

estrogen receptor
Refseq ID NP_694491
Protein GI 23308675
UniProt ID P57717
mRNA ID NM_152959
Length 569
RefSeq Status PROVISIONAL
MYPKEEHSAGGISSSVNYLDGAYEYPNPTQTFGTSSPAEPASVGYYPAPPDPHEEHLQTLGGGSSSPLMFAPSSPQLSPYLSHHGGHHTTPHQVSYYLDSSSSTVYRSSVVSSQQAAVGLCEELCSATDRQELYTGSRAAGGFDSGKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQACRLRKCYEVGMMKGGIRKDRGGRSVRRERRRSSNEDRDKSSSDQCSRAGVRTTGPQDKRKKRSGGVVSTLCMSPDQVLLLLLGAEPPAVCSRQKHSRPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPGKLIFAQDLILDRSEGECVEGMAEIFDMLLATVARFRSLKLKLEEFVCLKAIILINSGAFSFCSSPVEPLMDNFMVQCMLDNITDALIYCISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQRFQSSGKVQRVWSQSEKNPPSTPTTSSSSSNNSPRGGAAAIQSNGACHSHSPDP

Gene Information

Entrez Gene ID
259252
Gene Name
estrogen receptor 1
Gene Symbol
esr1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 ISS:UniProtKB C nucleus
GO:0030284 IEA:InterPro F estrogen receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001292 Oestrogen receptor
IPR024178 Oestrogen receptor/oestrogen-related receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
estrogen receptor 1
Protein Entry
ESR1_DANRE
UniProt ID
P57717
Species
Zebrafish

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Binds DNA as a homodimer. Can form a heterodimer with ER- beta (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011524 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23308675 RefSeq NP_694491 569 estrogen receptor

Identical Sequences to LMP011524 proteins

Reference Database Accession Length Protein Name
GI:23308675 GenBank AAK16740.1 569 estrogen receptor alpha [Danio rerio]
GI:23308675 SwissProt P57717.2 569 RecName: Full=Estrogen receptor; Short=ER; AltName: Full=ER-alpha; AltName: Full=Estradiol receptor; AltName: Full=Nuclear receptor subfamily 3 group A member 1 [Danio rerio]

Related Sequences to LMP011524 proteins

Reference Database Accession Length Protein Name
GI:23308675 DBBJ BAB16893.1 569 estrogen receptor [Danio rerio]
GI:23308675 GenBank ABS88330.1 621 estrogen receptor alpha long isoform [Danio rerio]
GI:23308675 GenBank AAI62466.1 569 Estrogen receptor 1 [Danio rerio]
GI:23308675 GenBank ADF31911.1 569 estrogen receptor 1 [Expression vector pCS2+zesr1]
GI:23308675 RefSeq XP_009297713.1 613 PREDICTED: estrogen receptor isoform X2 [Danio rerio]
GI:23308675 RefSeq XP_009297734.1 569 PREDICTED: estrogen receptor isoform X1 [Danio rerio]