Gene/Proteome Database (LMPD)

LMPD ID
LMP011555
Gene ID
324188
Species
Danio rerio (Zebrafish)
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
cyp26b1
Synonyms
fc21d03; zgc:76999; wu:fc21d03; wu:fc26h10
Chromosome
7

Proteins

cytochrome P450 26B1
Refseq ID NP_997831
Protein GI 47086709
UniProt ID Q6EIG3
mRNA ID NM_212666
Length 511
RefSeq Status PROVISIONAL
MLFESFDLVSALATLAACLVSMALLLAVSQQLWQLRWTATRDKSCKLPMPKGSMGFPIIGETCHWFFQGAGFHASRRQKYGNVFKTHLLGRPLIRVTGAENVRKVLMGEHSLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKIFAKVFSHEALESYLPKIQQVIQETLRVWSSNPDPINVYRESQRLSFNMAVRVLLGFRIPEEEMHCLFSTFQEFVENVFSLPIDLPFSGYRKGIRARDSLQKSIEKAIREKPLHTQGKDYTDALDVLLESAKENNTELTMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHDGCLCQGELRLDSIISLKYLDCVIKEVLRLFAPVSGGYRIATQTFELDGVQVPKGWSVMYSIRDTHDTSAVFKDVEAFDPDRFSPERSEDREGRFHYLPFGGGVRSCLGKQLATLFLKLLAVELAGGSRFELSTRTFPRMISVPVVHPTDGLRVKFFGLDSNQNQIMAKSDEMLDATV

Gene Information

Entrez Gene ID
324188
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
cyp26b1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:UniProtKB-KW F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0060349 IMP:ZFIN P bone morphogenesis
GO:0060536 IMP:ZFIN P cartilage morphogenesis
GO:0060365 IMP:ZFIN P coronal suture morphogenesis
GO:0060363 IMP:ZFIN P cranial suture morphogenesis
GO:0048701 IMP:ZFIN P embryonic cranial skeleton morphogenesis
GO:0060323 IMP:ZFIN P head morphogenesis
GO:0030902 IGI:ZFIN P hindbrain development
GO:0048387 IDA:UniProtKB P negative regulation of retinoic acid receptor signaling pathway
GO:0030278 IMP:ZFIN P regulation of ossification
GO:0034653 IMP:ZFIN P retinoic acid catabolic process
GO:0042573 TAS:UniProtKB P retinoic acid metabolic process
GO:0021661 IGI:ZFIN P rhombomere 4 morphogenesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR017972 Cytochrome P450, conserved site
IPR002403 Cytochrome P450, E-class, group IV

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Protein Entry
Q6EIG3_DANRE
UniProt ID
Q6EIG3
Species
Zebrafish

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Developmental Stage Expressed zygotically. Weak expression at 75% epiboly. At the 2-somite stage, expressed in the presumptive rhombomere 4 (r4) region partially overlapping with the r3 region. At the 10-somite stage, expressed in the r4, r3 and r2 regions. At the 14-somite stage, expression extends to the r5 and r6 regions and is observed in the diencephalon. At 24-48 hours post- fertilization (hpf), additionally expressed in the eye, midbrain- hindbrain boundary, cerebellum, pectoral fin and the pharyngeal arch primordia.
Function Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP011555 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47086709 RefSeq NP_997831 511 cytochrome P450 26B1

Identical Sequences to LMP011555 proteins

Reference Database Accession Length Protein Name
GI:47086709 EMBL CBF74429.1 511 unnamed protein product [Danio rerio]
GI:47086709 EMBL CBU96652.1 511 unnamed protein product [Danio rerio]
GI:47086709 GenBank AAH66759.1 511 Cytochrome P450, family 26, subfamily b, polypeptide 1 [Danio rerio]
GI:47086709 GenBank AGX64080.1 511 Sequence 28264 from patent US 8541208

Related Sequences to LMP011555 proteins

Reference Database Accession Length Protein Name
GI:47086709 GenBank AAQ82596.1 511 Cyp26b1 [Danio rerio]
GI:47086709 RefSeq XP_003966921.1 512 PREDICTED: cytochrome P450 26B1-like [Takifugu rubripes]
GI:47086709 RefSeq XP_007248161.1 511 PREDICTED: cytochrome P450 26B1-like [Astyanax mexicanus]
GI:47086709 RefSeq XP_008303277.1 512 PREDICTED: cytochrome P450 26B1 [Stegastes partitus]
GI:47086709 RefSeq XP_008433847.1 512 PREDICTED: cytochrome P450 26B1 [Poecilia reticulata]
GI:47086709 SwissProt Q6EIG3.1 511 RecName: Full=Cytochrome P450 26B1; Short=Cyp26B1; AltName: Full=Retinoic acid-metabolizing cytochrome [Danio rerio]