Gene/Proteome Database (LMPD)

LMPD ID
LMP011575
Gene ID
327417
Species
Danio rerio (Zebrafish)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 12a
Gene Symbol
hsd17b12a
Synonyms
fi06g11; zgc:55589; zgc:77599; wu:fi06g11
Alternate Names
estradiol 17-beta-dehydrogenase 12-A; zf3.1; zf 3.1; zfHSD17B12A; 17-beta-HSD 12-A; 17-beta-hydroxysteroid dehydrogenase 12-A; 17-beta hydroxysteroid dehydrogenase type 12A, 3-ketoacyl-CoA reductase type A
Chromosome
25
EC Number
1.1.1.62

Proteins

estradiol 17-beta-dehydrogenase 12-A
Refseq ID NP_957175
Protein GI 54261751
UniProt ID Q6P3L6
mRNA ID NM_200881
Length 319
RefSeq Status PROVISIONAL
MESFNVVETLQPAERALFWVGALITASLALYVVYKTITGFRIWVLGNGDLLSPKLGKWAVVTGATDGIGKSYAEELARRGFSMMLISRSQEKLDDVAKSLESTYKVETKTIAVDFSQIDVYPKIEKGLAGLEIGILVNNVGISYSYPEFFLHIPDLENFITTMINVNITSVCQMTRLVLPRMEARAKGVILNISSASGMFPVPLLTIYSSTKAFVDFFSRGLQTEYKCKGIIIQSVLPFFVATKMTKIRKPTLDKPTPERYVAAELNTVGLQDQTNGYFPHAVMGWVTTILAPIDLVLNLGLRMNKAQRGGYLRRRKLR

Gene Information

Entrez Gene ID
327417
Gene Name
hydroxysteroid (17-beta) dehydrogenase 12a
Gene Symbol
hsd17b12a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0006703 IEA:UniProtKB-UniPathway P estrogen biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dre01040 Biosynthesis of unsaturated fatty acids
dre_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
dre00062 Fatty acid elongation
dre00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 12a
Protein Entry
DH12A_DANRE
UniProt ID
Q6P3L6
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Developmental Stage Expressed throughout development. Weakly expressed during early developmental stages from shield to tailbud. {ECO:0000269|PubMed:15026171}.
Function Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. {ECO:0000250}.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011575 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54261751 RefSeq NP_957175 319 estradiol 17-beta-dehydrogenase 12-A

Identical Sequences to LMP011575 proteins

Reference Database Accession Length Protein Name
GI:54261751 GenBank AAH63943.1 319 Hydroxysteroid (17-beta) dehydrogenase 12a [Danio rerio]
GI:54261751 GenBank AAS58452.1 319 17-beta hydroxysteroid dehydrogenase type 12A, 3-ketoacyl-CoA reductase type A [Danio rerio]
GI:54261751 SwissProt Q6P3L6.1 319 RecName: Full=Estradiol 17-beta-dehydrogenase 12-A; AltName: Full=17-beta-hydroxysteroid dehydrogenase 12-A; Short=17-beta-HSD 12-A; Short=zf3.1; Short=zfHSD17B12A [Danio rerio]

Related Sequences to LMP011575 proteins

Reference Database Accession Length Protein Name
GI:54261751 GenBank AAH48053.1 319 Hydroxysteroid (17-beta) dehydrogenase 12a [Danio rerio]
GI:54261751 GenBank AAI64345.1 319 Hsd17b12a protein [Danio rerio]
GI:54261751 RefSeq XP_003455445.2 327 PREDICTED: estradiol 17-beta-dehydrogenase 12-A-like [Oreochromis niloticus]
GI:54261751 RefSeq XP_007244314.1 311 PREDICTED: estradiol 17-beta-dehydrogenase 12-A-like isoform X1 [Astyanax mexicanus]
GI:54261751 RefSeq XP_007244315.1 311 PREDICTED: estradiol 17-beta-dehydrogenase 12-A-like isoform X2 [Astyanax mexicanus]
GI:54261751 RefSeq XP_008292297.1 330 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Stegastes partitus]