Gene/Proteome Database (LMPD)

LMPD ID
LMP011586
Gene ID
334270
Species
Danio rerio (Zebrafish)
Gene Name
acylglycerol kinase
Gene Symbol
agk
Synonyms
mulk; fi38e09; zgc:55462; wu:fi38e09
Alternate Names
acylglycerol kinase, mitochondrial; multi-substrate lipid kinase; multiple substrate lipid kinase
Chromosome
18
EC Number
2.7.1.107

Proteins

acylglycerol kinase, mitochondrial precursor
Refseq ID NP_956174
Protein GI 41054059
UniProt ID Q7ZW00
mRNA ID NM_199880
Length 422
RefSeq Status PROVISIONAL
MARVVKVFRTLRNHWKKSTFAVCVLSYGGHWLYGKHCDSVLRREACIEARAFGQQLIGPQEILKKATVILNPAACKGKANQLFEKNAAPILHLAGVEVKIVKTDYEGQAKKLMELMEQTDMLIIAGGDGTLQEVITGLLRRADEEIFSKTPIGFIPLGSSNSLSQSLHLVSDNKVQHITSATLSILKGETVPLDVLQIKGEKEQPVFALLGLRWGAFRDVATSISKYWYLGPLKTRAAHWFSSLKQWPQVHVASLSYLAPVPRPPDLPDEIPQRPNLLYRIYRRLQNYWNPPLEEPPKEPEPEQWESKDVSTLELTVLTHNKNPVKRRVDDSMLISLDPESLTAGQFITEGTNKSVDPMEPIENAVQIEASAARLELPEEGAGFYDIDNQEYEAMSVEVRLLPRKLRFFCSAERREQLAEAQ

Gene Information

Entrez Gene ID
334270
Gene Name
acylglycerol kinase
Gene Symbol
agk
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0047620 IEA:UniProtKB-EC F acylglycerol kinase activity
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0046486 IEA:UniProtKB-UniPathway P glycerolipid metabolic process
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
dre00561 Glycerolipid metabolism
ko00561 Glycerolipid metabolism
dre01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
acylglycerol kinase
Protein Entry
AGK_DANRE
UniProt ID
Q7ZW00
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Catalytic Activity ATP + acylglycerol = ADP + acyl-sn-glycerol 3- phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. {ECO:0000250}.
Pathway Lipid metabolism; glycerolipid metabolism.
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular Location Mitochondrion membrane {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011586 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41054059 RefSeq NP_956174 422 acylglycerol kinase, mitochondrial precursor

Identical Sequences to LMP011586 proteins

Reference Database Accession Length Protein Name
GI:41054059 GenBank AAH45347.1 422 Acylglycerol kinase [Danio rerio]

Related Sequences to LMP011586 proteins

Reference Database Accession Length Protein Name
GI:41054059 EMBL CDQ72778.1 423 unnamed protein product [Oncorhynchus mykiss]
GI:41054059 GenBank ACI34075.1 423 Acylglycerol kinase, mitochondrial precursor [Salmo salar]
GI:41054059 GenBank AHH37287.1 422 Acylglycerol kinase, mitochondrial [Ictalurus punctatus]
GI:41054059 RefSeq XP_003447107.1 423 PREDICTED: acylglycerol kinase, mitochondrial-like [Oreochromis niloticus]
GI:41054059 RefSeq XP_007256032.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Astyanax mexicanus]
GI:41054059 SwissProt Q7ZW00.2 422 RecName: Full=Acylglycerol kinase, mitochondrial; AltName: Full=Multiple substrate lipid kinase; Short=MuLK; Short=Multi-substrate lipid kinase; Flags: Precursor [Danio rerio]