Gene/Proteome Database (LMPD)

LMPD ID
LMP011630
Gene ID
373867
Species
Danio rerio (Zebrafish)
Gene Name
phospholipase C, gamma 1
Gene Symbol
plcg1
Synonyms
fj46f04; wu:fj46f04; wu:fj57a05
Chromosome
23

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Refseq ID NP_919388
Protein GI 35903054
UniProt ID Q804J6
mRNA ID NM_194407
Length 1312
RefSeq Status PROVISIONAL
MAASAGFSSNGPVPWALSDTEVNNLYRDLELGTVLTLYYSKKSQRPERRTFQVKLETRQIIWTRGTDKIEGEIDIREIKEIRTGQKSRDFERYVEDVTTRPDQAHCFVILYGTEFRLKSLSLAATSDEEMVMWVKGLTWLMSDTLSSSTPLQIERWLRKQFYAVDRNREDRISCKDLKCMLCQVNYRVPNMKFLREKLPDGELRNGDVSYSHFAQLYRSLMFDAQKSMEIPLLQRFIDRPEQKISLEDFQNFLIEQQKELWAADSNKVQEYMFRYLKDPLREIEQPYFHQDEFLTYLFSKENTIWDAQLDQVRPEDMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLNTIKEHAFVTSDYPIILSIEDHCSIVQQRNMATFFKKVFGEMLLTKAVDISADGLPSPHQLKRKILIKHKKLAEGSAYEEVSSSTPYSENDISNSIKNGILYLEDPINHEWYPHFFVLTSNKIYYSEETSSNQGNEDEEEHREICNGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCVETGAPDGSFLVRESETFVGDYTLSFWRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFALITHYQQVPLRCNEFEMKLTEPVPQTNAHESKEWYHACLSRSQAENMLMRVPRDGAFLVRKRTEFNSFAISFRAEGKIKHCRVQQEGQTVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEETLEKIGTAEPDYGSLYEGRNPGFYVEANQMPTFKCTVKAMYEYKAQRDDELSFIKNAIISNVDKQEGGWWKGDCGGKKQLWFPANYVEEISPTAVEPDRSASENSPLGDLLRGSVDVSSCQIVVRPEGKGSRQFVFSLVPVASPRTGPVLDIAASSQEELKDWVVKIREVTMTSEAKLEEGKMMERRKKIALELSDLVIYCRPVPFDEDKIGTERACFRDMSSFPETKAEKYVNRVKGKKFLQYNRLQLSRIYPRGQRLDSSNYDPLPMWLCGSQLVALNFQTADKPMQMNQAIFMLNGRSGYVLQPPIMRDDNFDPFDRHSLRGVEPITLSIEVLGARHLPKHGRGIVCPLIEIEVCGAEYDNAKQRTDSEADNGLNPTWTRKLFRFTVCNPSFAFLRFVVYEIDMFSDQNFLAQATFPINCLKTGYRSVPLKNSYSEDLELACLLVHMDVIRGRVGYEMIHENGDMLSPFSPAGAMAMAMQTGRERMNDSGSVSSTSSMSPLPSSPAQALGYRGREGSFEARYQTPLEDFRVSQEALLDHENRRLRRARVSADNRA

Gene Information

Entrez Gene ID
373867
Gene Name
phospholipase C, gamma 1
Gene Symbol
plcg1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0001525 IMP:ZFIN P angiogenesis
GO:0048844 IMP:ZFIN P artery morphogenesis
GO:0031101 IMP:ZFIN P fin regeneration
GO:0030851 IMP:ZFIN P granulocyte differentiation
GO:0060218 IMP:ZFIN P hematopoietic stem cell differentiation
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0035477 IMP:ZFIN P regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016 IMP:ZFIN P regulation of heart contraction
GO:0001570 IMP:ZFIN P vasculogenesis

Domain Information

InterPro Annotations

Accession Description
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, gamma 1
Protein Entry
Q804J6_DANRE
UniProt ID
Q804J6
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Similarity Contains 1 C2 domain.
Similarity Contains 1 PI-PLC X-box domain.
Similarity Contains 1 PI-PLC Y-box domain.
Similarity Contains 1 SH3 domain.
Similarity Contains 3 PH domains.
Similarity Contains C2 domain.
Similarity Contains Cdomain.
Similarity Contains PI-PLC X-box domain.
Similarity Contains PI-PLC Y-box domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP011630 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
35903054 RefSeq NP_919388 1312 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Identical Sequences to LMP011630 proteins

Reference Database Accession Length Protein Name
GI:35903054 EMBL CBF74655.1 1312 unnamed protein product [Danio rerio]
GI:35903054 EMBL CBF62929.1 1312 unnamed protein product [Danio rerio]
GI:35903054 EMBL CBU87805.1 1312 unnamed protein product [Danio rerio]
GI:35903054 EMBL CBU96752.1 1312 unnamed protein product [Danio rerio]
GI:35903054 GenBank AGX54740.1 1312 Sequence 9836 from patent US 8541208
GI:35903054 GenBank AGX64180.1 1312 Sequence 28470 from patent US 8541208

Related Sequences to LMP011630 proteins

Reference Database Accession Length Protein Name
GI:35903054 GenBank AAI62663.1 1312 Phospholipase C, gamma 1 [Danio rerio]
GI:35903054 GenBank AHH37970.1 1306 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [Ictalurus punctatus]
GI:35903054 RefSeq XP_003963404.1 1351 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [Takifugu rubripes]
GI:35903054 RefSeq XP_005448876.1 1311 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [Oreochromis niloticus]
GI:35903054 RefSeq XP_008291860.1 1314 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [Stegastes partitus]
GI:35903054 RefSeq XP_008291861.1 1313 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [Stegastes partitus]