Gene/Proteome Database (LMPD)

LMPD ID
LMP011632
Gene ID
378446
Species
Danio rerio (Zebrafish)
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
dhcr7
Alternate Names
7-dehydrocholesterol reductase; 7-DHC reductase; sterol Delta(7)-reductase
Chromosome
2
EC Number
1.3.1.21

Proteins

7-dehydrocholesterol reductase
Refseq ID NP_958487
Protein GI 41152207
UniProt ID Q7SXF1
mRNA ID NM_201330
Length 478
RefSeq Status PROVISIONAL
MMASDRVRKRHKGSANGAQTVEKEPSKEPAQWGRAWEVDWFSLSGVILLLCFAPFLVSFFIMACDQYQCSISHPLLDLYNGDATLFTIWNRAPSFTWAAAKIYAIWVTFQVVLYMCVPDFLHKILPGYVGGVQDGARTPAGLINKYEVNGLQCWLITHVLWVLNAQHFHWFSPTIIIDNWIPLLWCTNILGYAVSTFAFIKAYLFPTNPEDCKFTGNMFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGYVTNSMILVNVLQAVYVVDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPFLYTLQGLYLVYNPIQLSTPHAAGVLILGLVGYYIFRVTNHQKDLFRRTEGNCSIWGKKPTFIECSYQSADGAIHKSKLMTSGFWGVARHMNYTGDLMGSLAYCLACGGNHLLPYFYIIYMTILLVHRCIRDEHRCSNKYGKDWERYTAAVSYRLLPNIF

Gene Information

Entrez Gene ID
378446
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
dhcr7
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047598 IEA:UniProtKB-EC F 7-dehydrocholesterol reductase activity
GO:0006695 IEA:UniProtKB-UniPathway P cholesterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dre_M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
dre01100 Metabolic pathways
dre00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR018083 Sterol reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
7-dehydrocholesterol reductase
Protein Entry
DHCR7_DANRE
UniProt ID
Q7SXF1
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity Cholesterol + NADP(+) = cholesta-5,7-dien-3- beta-ol + NADPH.
Function Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). {ECO:0000250}.
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Similarity Belongs to the ERG4/ERG24 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011632 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41152207 RefSeq NP_958487 478 7-dehydrocholesterol reductase

Identical Sequences to LMP011632 proteins

Reference Database Accession Length Protein Name
GI:41152207 GenBank AAH55631.1 478 7-dehydrocholesterol reductase [Danio rerio]
GI:41152207 SwissProt Q7SXF1.1 478 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Danio rerio]

Related Sequences to LMP011632 proteins

Reference Database Accession Length Protein Name
GI:41152207 EMBL CDQ78012.1 565 unnamed protein product [Oncorhynchus mykiss]
GI:41152207 GenBank AHH37626.1 478 7-dehydrocholesterol reductase [Ictalurus punctatus]
GI:41152207 RefSeq XP_003437630.1 472 PREDICTED: 7-dehydrocholesterol reductase-like isoform X1 [Oreochromis niloticus]
GI:41152207 RefSeq XP_004539887.1 472 PREDICTED: 7-dehydrocholesterol reductase-like [Maylandia zebra]
GI:41152207 RefSeq XP_007254692.1 478 PREDICTED: 7-dehydrocholesterol reductase [Astyanax mexicanus]
GI:41152207 RefSeq XP_008277413.1 472 PREDICTED: 7-dehydrocholesterol reductase [Stegastes partitus]