Gene/Proteome Database (LMPD)
Proteins
| lipoyl synthase, mitochondrial | |
|---|---|
| Refseq ID | NP_001103871 |
| Protein GI | 160333642 |
| UniProt ID | Q6PHG4 |
| mRNA ID | NM_001110401 |
| Length | 397 |
| RefSeq Status | PROVISIONAL |
| MALISRSCGAASRYSSSHLFLPSKGAEAANVYCNRLSTAASTSSSSSPSTHNDRKKDLREDGLNLQDFISGELSEKSKWEEYRGNLKREKGERLRLPPWLKTEIPIGKNYNKLKNTLRELNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARRPPPLDPDEPYNTAKAIAAWGLDYVVLTSVDRDDIPDGGAEHFAKTVSNIKERNSKILVECLTPDFRGDLAAVEKIALSGLDVYAHNVETVRELQRHVRDPRANFDQSLSVLRHAKKVKSSVLTKTSIMLGLGETDAQIQATLTELRDSGVDCLTLGQYMQPTKRHLKVEEYVTPEKFAFWEKVGQEMGFIYTASGPLVRSSYKAGEFFLKNLLEKRKTEETTATAE | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IEA:UniProtKB-HAMAP | C | mitochondrion |
| GO:0051539 | IEA:UniProtKB-HAMAP | F | 4 iron, 4 sulfur cluster binding |
| GO:0016992 | IEA:UniProtKB-HAMAP | F | lipoate synthase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0009249 | IEA:UniProtKB-HAMAP | P | protein lipoylation |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Protein N(6)-(octanoyl)lysine + 2 sulfur- (sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)- (lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'- deoxyadenosine. |
| Cofactor | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000255|HAMAP-Rule:MF_03123}; Note=Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. {ECO:0000255|HAMAP-Rule:MF_03123}; |
| Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}. |
| Pathway | Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03123}. |
| Similarity | Belongs to the radical SAM superfamily. Lipoyl synthase family. {ECO:0000255|HAMAP-Rule:MF_03123}. |
| Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011672 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 160333642 | RefSeq | NP_001103871 | 397 | lipoyl synthase, mitochondrial |
Identical Sequences to LMP011672 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:160333642 | GenBank | AAI54782.1 | 397 | Zgc:66080 protein [Danio rerio] |
Related Sequences to LMP011672 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:160333642 | EMBL | CBN72415.1 | 399 | unnamed protein product [Danio rerio] |
| GI:160333642 | GenBank | AAH56561.1 | 399 | Zgc:66080 [Danio rerio] |
| GI:160333642 | RefSeq | XP_004564359.1 | 385 | PREDICTED: lipoyl synthase, mitochondrial-like [Maylandia zebra] |
| GI:160333642 | RefSeq | XP_005928364.1 | 385 | PREDICTED: lipoyl synthase, mitochondrial-like [Haplochromis burtoni] |
| GI:160333642 | RefSeq | XP_008276634.1 | 414 | PREDICTED: lipoyl synthase, mitochondrial [Stegastes partitus] |
| GI:160333642 | SwissProt | Q6PHG4.1 | 399 | RecName: Full=Lipoyl synthase, mitochondrial; AltName: Full=Lipoate synthase; Short=LS; Short=Lip-syn; AltName: Full=Lipoic acid synthase; Flags: Precursor [Danio rerio] |