Gene/Proteome Database (LMPD)

LMPD ID
LMP011696
Gene ID
393953
Species
Danio rerio (Zebrafish)
Gene Name
protein kinase C, beta b
Gene Symbol
prkcbb
Synonyms
PKC-B; Prkcb; prkcb1; zgc:63591
Alternate Names
protein kinase C beta type; PKC-beta; protein kinase C, beta 1
Chromosome
3
EC Number
2.7.11.13

Proteins

protein kinase C beta type
Refseq ID NP_957272
Protein GI 41055807
UniProt ID Q7SY24
mRNA ID NM_200978
Length 670
RefSeq Status PROVISIONAL
MAEPANSDGEERSAPMRGFARQGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKVHTYSSPTFCDHCGSLLYGLIHQGMRCDHCMMNIHKRCVANVPSLCGTDHTERRGRIQITAEIKNNVLTVSIKEAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCCLNPTWNETFTFNLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKQGVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIGPSKTDGSSSNAISKFDSNGNRDRMKLSDFNFLMVLGKGSFGKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVLALSGKPPFLTQLHSCFQTMDRLYFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGVIYRDLKLDNVMLDAEGHIKIADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIREHGFFRYMDWEKLEHREVQPPFKPKACGRDAENFDRFFTRHPPVLTPPDQEVIMNLDQDEFEGFSFINPEFPAMEAQS

Gene Information

Entrez Gene ID
393953
Gene Name
protein kinase C, beta b
Gene Symbol
prkcbb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005634 ISS:UniProtKB C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0050681 ISS:UniProtKB F androgen receptor binding
GO:0003682 ISS:UniProtKB F chromatin binding
GO:0042393 ISS:UniProtKB F histone binding
GO:0035403 ISS:UniProtKB F histone kinase activity (H3-T6 specific)
GO:0030374 ISS:UniProtKB F ligand-dependent nuclear receptor transcription coactivator activity
GO:0004697 IEA:UniProtKB-EC F protein kinase C activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0042113 ISS:UniProtKB P B cell activation
GO:0050853 ISS:UniProtKB P B cell receptor signaling pathway
GO:0006915 IEA:UniProtKB-KW P apoptotic process
GO:0035162 IMP:ZFIN P embryonic hemopoiesis
GO:0035408 ISS:UniProtKB P histone H3-T6 phosphorylation
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0043123 ISS:UniProtKB P positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0006357 ISS:UniProtKB P regulation of transcription from RNA polymerase II promoter
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR000961 AGC-kinase, C-terminal
IPR000008 C2 domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR014375 Protein kinase C, alpha/beta/gamma types
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR017892 Protein kinase, C-terminal
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
protein kinase C, beta b
Protein Entry
KPCB_DANRE
UniProt ID
Q7SY24
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. {ECO:0000250};
Enzyme Regulation Activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. {ECO:0000250}.
Function Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF- kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity). {ECO:0000250}.
Ptm Phosphorylation on Thr-497 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-638 maintains catalytic competence, and autophosphorylation on Ser-657 appears to release the kinase into the cytosol (By similarity). {ECO:0000250}.
Similarity Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. {ECO:0000305}.
Similarity Contains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011696 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41055807 RefSeq NP_957272 670 protein kinase C beta type

Identical Sequences to LMP011696 proteins

Reference Database Accession Length Protein Name
GI:41055807 GenBank AAH55154.1 670 Protein kinase C, beta 1 [Danio rerio]
GI:41055807 SwissProt Q7SY24.1 670 RecName: Full=Protein kinase C beta type; Short=PKC-B; Short=PKC-beta [Danio rerio]

Related Sequences to LMP011696 proteins

Reference Database Accession Length Protein Name
GI:41055807 RefSeq XP_005164062.1 670 PREDICTED: protein kinase C beta type isoform X1 [Danio rerio]
GI:41055807 RefSeq XP_005459488.1 680 PREDICTED: protein kinase C beta type-like isoform X2 [Oreochromis niloticus]
GI:41055807 RefSeq XP_005743564.1 680 PREDICTED: protein kinase C beta type-like isoform X1 [Pundamilia nyererei]
GI:41055807 RefSeq XP_006798105.1 680 PREDICTED: protein kinase C beta type-like isoform X1 [Neolamprologus brichardi]
GI:41055807 RefSeq XP_008282618.1 667 PREDICTED: protein kinase C beta type isoform X1 [Stegastes partitus]
GI:41055807 RefSeq XP_008290081.1 680 PREDICTED: protein kinase C beta type [Stegastes partitus]