Gene/Proteome Database (LMPD)

LMPD ID
LMP011699
Gene ID
394001
Species
Danio rerio (Zebrafish)
Gene Name
adaptor-related protein complex 2, mu 1 subunit, b
Gene Symbol
ap2m1b
Synonyms
ap2m1; zgc:56643
Alternate Names
AP-2 complex subunit mu-B; mu2-adaptin-B; AP-2 mu-B chain; AP-2 mu-2 chain B; AP-2 complex subunit mu-1-B; clathrin coat assembly protein AP50-B; clathrin coat-associated protein AP50-B; plasma membrane adaptor AP-2 50 kDa protein B; clathrin assembly protein complex 2 medium chain B; clathrin assembly protein complex 2 mu-B medium chain
Chromosome
18

Proteins

AP-2 complex subunit mu-B
Refseq ID NP_957320
Protein GI 41056102
UniProt ID Q7ZW98
mRNA ID NM_201026
Length 436
RefSeq Status PROVISIONAL
MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMTAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHLTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIDKQGKGGTTDDTGKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEYELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMVGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC

Gene Information

Entrez Gene ID
394001
Gene Name
adaptor-related protein complex 2, mu 1 subunit, b
Gene Symbol
ap2m1b
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030131 IEA:InterPro C clathrin adaptor complex
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0006886 IEA:InterPro P intracellular protein transport

KEGG Pathway Links

KEGG Pathway ID Description
dre04144 Endocytosis

REACTOME Pathway Links

REACTOME Pathway ID Description
6176956 EPH-ephrin mediated repulsion of cells
6176320 Formation of annular gap junctions
6176560 Trafficking of GluR2-containing AMPA receptors

Domain Information

InterPro Annotations

Accession Description
IPR022775 AP complex, mu/sigma subunit
IPR001392 Clathrin adaptor, mu subunit
IPR018240 Clathrin adaptor, mu subunit, conserved site
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR028565 Mu homology domain

UniProt Annotations

Entry Information

Gene Name
adaptor-related protein complex 2, mu 1 subunit, b
Protein Entry
AP2MB_DANRE
UniProt ID
Q7ZW98
Species
Zebrafish

Comments

Comment Type Description
Function Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity). {ECO:0000250}.
Similarity Belongs to the adaptor complexes medium subunit family. {ECO:0000305}.
Similarity Contains 1 MHD (mu homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00404}.
Subcellular Location Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Subunit Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011699 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41056102 RefSeq NP_957320 436 AP-2 complex subunit mu-B

Identical Sequences to LMP011699 proteins

Reference Database Accession Length Protein Name
GI:41056102 GenBank AAH49515.1 436 Adaptor-related protein complex 2, mu 1 subunit [Danio rerio]
GI:41056102 SwissProt Q7ZW98.1 436 RecName: Full=AP-2 complex subunit mu-B; AltName: Full=AP-2 mu-B chain; AltName: Full=Clathrin assembly protein complex 2 mu-B medium chain; AltName: Full=Clathrin coat assembly protein AP50-B; AltName: Full=Clathrin coat-associated protein AP50-B; AltName: Full=Mu2-adaptin-B; AltName: Full=Plasma membrane adaptor AP-2 50 kDa protein B [Danio rerio]

Related Sequences to LMP011699 proteins

Reference Database Accession Length Protein Name
GI:41056102 GenBank AAH67560.1 436 Zgc:85653 [Danio rerio]
GI:41056102 RefSeq NP_997742.1 436 AP-2 complex subunit mu-A isoform 2 [Danio rerio]
GI:41056102 RefSeq XP_005171208.1 436 PREDICTED: AP-2 complex subunit mu-A isoform X1 [Danio rerio]
GI:41056102 RefSeq XP_005159313.1 436 PREDICTED: AP-2 complex subunit mu-B isoform X1 [Danio rerio]
GI:41056102 RefSeq XP_009292135.1 441 PREDICTED: AP-2 complex subunit mu-B isoform X2 [Danio rerio]
GI:41056102 SwissProt Q6NWK2.1 436 RecName: Full=AP-2 complex subunit mu-A; AltName: Full=AP-2 mu-A chain; AltName: Full=Clathrin assembly protein complex 2 mu-A medium chain; AltName: Full=Clathrin coat assembly protein AP50-A; AltName: Full=Clathrin coat-associated protein AP50-A; AltName: Full=Mu2-adaptin-A; AltName: Full=Plasma membrane adaptor AP-2 50 kDa protein A [Danio rerio]