Gene/Proteome Database (LMPD)

LMPD ID
LMP011724
Gene ID
402954
Species
Danio rerio (Zebrafish)
Gene Name
carbonyl reductase 4
Gene Symbol
cbr4
Synonyms
zgc:77144; im:6908596
Alternate Names
carbonyl reductase family member 4; quinone reductase CBR4; 3-oxoacyl-[acyl-carrier-protein] reductase
Chromosome
20
EC Number
1.-.-.-

Proteins

carbonyl reductase family member 4
Refseq ID NP_991219
Protein GI 45387727
UniProt ID Q6P0H7
mRNA ID NM_205656
Length 237
RefSeq Status PROVISIONAL
MSRLAVVFGGSRGIGRAASKLLAQRGHRIVLLSRNKEAAQSTAQSLPGENHLGLSCDVSKEEEVQKAFETINKTCGTVGFLVNAAGINRDALLLRSKSEDMLSVLHTNLLGSMLTCKAAVRNMLSHGGAIVNIGSVVGVKGNAGQCVYSASKAGLEGFTRSLAKEVASRNIRVNLVAPGLIHTDMTAGLAEEAAVRTIPLGRFGEPAEVAQAMLFLLESPYITGQILLVDGGLQLLM

Gene Information

Entrez Gene ID
402954
Gene Name
carbonyl reductase 4
Gene Symbol
cbr4
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0016491 IEA:UniProtKB-KW F oxidoreductase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
carbonyl reductase 4
Protein Entry
CBR4_DANRE
UniProt ID
Q6P0H7
Species
Zebrafish

Comments

Comment Type Description
Function The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4 (Potential). {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011724 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45387727 RefSeq NP_991219 237 carbonyl reductase family member 4

Identical Sequences to LMP011724 proteins

Reference Database Accession Length Protein Name
GI:45387727 EMBL CBF61733.1 237 unnamed protein product [Danio rerio]
GI:45387727 EMBL CBU86609.1 237 unnamed protein product [Danio rerio]
GI:45387727 GenBank AAH65615.1 237 Zgc:77144 [Danio rerio]
GI:45387727 GenBank AGX53495.1 237 Sequence 7359 from patent US 8541208
GI:45387727 SwissProt Q6P0H7.1 237 RecName: Full=Carbonyl reductase family member 4; AltName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; AltName: Full=Quinone reductase CBR4 [Danio rerio]

Related Sequences to LMP011724 proteins

Reference Database Accession Length Protein Name
GI:45387727 GenBank ADO29458.1 237 carbonyl reductase family member 4 [Ictalurus punctatus]
GI:45387727 RefSeq NP_001188032.1 237 carbonyl reductase family member 4 [Ictalurus punctatus]
GI:45387727 RefSeq XP_007245392.1 237 PREDICTED: carbonyl reductase family member 4-like isoform X1 [Astyanax mexicanus]
GI:45387727 RefSeq XP_007245393.1 237 PREDICTED: carbonyl reductase family member 4-like isoform X2 [Astyanax mexicanus]
GI:45387727 RefSeq XP_007245394.1 237 PREDICTED: carbonyl reductase family member 4-like isoform X3 [Astyanax mexicanus]
GI:45387727 RefSeq XP_009292933.1 237 PREDICTED: carbonyl reductase family member 4 isoform X1 [Danio rerio]