Gene/Proteome Database (LMPD)

LMPD ID
LMP011765
Gene ID
406575
Species
Danio rerio (Zebrafish)
Gene Name
leukotriene A4 hydrolase
Gene Symbol
lta4h
Synonyms
zgc:85809
Chromosome
4

Proteins

leukotriene A-4 hydrolase
Refseq ID NP_998451
Protein GI 47086915
UniProt ID Q6NUX4
mRNA ID NM_213286
Length 611
RefSeq Status PROVISIONAL
MTPVSDPSSFSSLSKCSTKHLNLIYHVDFDRHVLKGKVALTVEVLEDKFSSLTLDSKDLKISKVSANGQAAKFELGAKHKFKGSPLEITLPFELSRGQHVIVEIEYETSPTATALQWLTPKQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIVVGALESREIGPRSRVWSEKEYVDEAAYEFAETETMLKTAESLAGPYVWGQYDVLVLPPSFPYGGMENPCLTFVTPTVLAGDRSLAGVIAHEISHSWTGNLVTNRTWEHFWLNEGHTVYIERMIARCMEGEQLRQFKGIGGWKELHESVKQFGANNVLTNLVPNLHEVDTDEAFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSVTTEEWKNYLFTYFKDKVDILNKVDWNAWMHTPGMAPVRPQYDTTMADACTSLCQKWVKAKEADLASFTEADVKQLNSPQLIEFMALLLQEDPLPLSHVKKMGEVYKLNNIKNAEVRFRWLRICVKAQWEEAVPLALKMATEQGRMKFTRPLFTEVYNFSKYSDEAVKTFKEIRGSLHPVTAMLVAKDLKIDG

Gene Information

Entrez Gene ID
406575
Gene Name
leukotriene A4 hydrolase
Gene Symbol
lta4h
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-SubCell C cytoplasm
GO:0004463 IEA:UniProtKB-EC F leukotriene-A4 hydrolase activity
GO:0008237 IEA:UniProtKB-KW F metallopeptidase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006954 IMP:ZFIN P inflammatory response
GO:0019370 IEA:UniProtKB-KW P leukotriene biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR012777 Leukotriene A4 hydrolase
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
leukotriene A4 hydrolase
Protein Entry
Q6NUX4_DANRE
UniProt ID
Q6NUX4
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.
Cofactor Note=Binds 1 zinc ion per subunit. ;
Pathway Lipid metabolism; leukotriene B4 biosynthesis.
Similarity Belongs to the peptidase M1 family.
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP011765 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47086915 RefSeq NP_998451 611 leukotriene A-4 hydrolase

Identical Sequences to LMP011765 proteins

Reference Database Accession Length Protein Name
GI:47086915 GenBank AAH68394.1 611 Leukotriene A4 hydrolase [Danio rerio]

Related Sequences to LMP011765 proteins

Reference Database Accession Length Protein Name
GI:47086915 EMBL CAI11594.1 611 novel protein (zgc:85809) [Danio rerio]
GI:47086915 EMBL CDQ67393.1 621 unnamed protein product [Oncorhynchus mykiss]
GI:47086915 EMBL CDQ64461.1 615 unnamed protein product [Oncorhynchus mykiss]
GI:47086915 GenBank ACI33534.1 622 Leukotriene A-4 hydrolase [Salmo salar]
GI:47086915 RefSeq NP_001133592.1 622 Leukotriene A-4 hydrolase [Salmo salar]
GI:47086915 RefSeq XP_007232319.1 615 PREDICTED: leukotriene A-4 hydrolase [Astyanax mexicanus]