Gene/Proteome Database (LMPD)

LMPD ID
LMP011850
Gene ID
445290
Species
Danio rerio (Zebrafish)
Gene Name
acetyl-CoA acetyltransferase 1
Gene Symbol
acat1
Synonyms
fd16h07; fd20g06; zgc:86832; wu:fd16h07; wu:fd20g06
Alternate Names
acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl-CoA thiolase; acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
Chromosome
10
EC Number
2.3.1.9

Proteins

acetyl-CoA acetyltransferase, mitochondrial precursor
Refseq ID NP_001003746
Protein GI 51230650
UniProt ID Q6AZA0
mRNA ID NM_001003746
Length 420
RefSeq Status PROVISIONAL
MTSRALYSTRSQLCRHLAHKYLSRSYSTRPSLNEVVIVSAVRTPIGSFKGSLSTLPATKLGSIAIKGAIDKAGIPVEEVKEVYMGNVLQAGEGQAPTRQALLGAGLPLSTPATTINKVCASGMKSIMLASQSLMCGHQDVMVAGGMESMSQVPYIMAREAPPYGGVKMEDLIVKDGLTDVYNKFHMGNCAENTAKNSSISREEQDAFAIKSYTLSKAAWESGILAKEVVPVSIPQRGKPDVVVKEDEEYRKVDFSKVPKLKAVFLKENGTVTAANASTLNDGAAALVLMTADAAQRLNVTPLAKIVAFADAAVAPIDFPIAPAFAVPKVLKAAGIKKEDIAMWEINEAFSVVVLANIKMLDIDPDRVNINGGAVSLGHPIGMSGARIVGHMVHNLKSGQYGLAGICNGGGGASSIVIQKF

Gene Information

Entrez Gene ID
445290
Gene Name
acetyl-CoA acetyltransferase 1
Gene Symbol
acat1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0003985 IEA:UniProtKB-EC F acetyl-CoA C-acetyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding

KEGG Pathway Links

KEGG Pathway ID Description
dre_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
dre01200 Carbon metabolism
dre00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acetyltransferase 1
Protein Entry
THIL_DANRE
UniProt ID
Q6AZA0
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
Function Plays a major role in ketone body metabolism. {ECO:0000250}.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011850 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51230650 RefSeq NP_001003746 420 acetyl-CoA acetyltransferase, mitochondrial precursor

Identical Sequences to LMP011850 proteins

Reference Database Accession Length Protein Name
GI:51230650 GenBank AAH78651.1 420 Acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) [Danio rerio]
GI:51230650 SwissProt Q6AZA0.1 420 RecName: Full=Acetyl-CoA acetyltransferase, mitochondrial; AltName: Full=Acetoacetyl-CoA thiolase; Flags: Precursor [Danio rerio]

Related Sequences to LMP011850 proteins

Reference Database Accession Length Protein Name
GI:51230650 GenBank AHH37817.1 417 Acetyl-CoA acetyltransferase, mitochondrial [Ictalurus punctatus]
GI:51230650 RefSeq XP_003449855.1 420 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial-like [Oreochromis niloticus]
GI:51230650 RefSeq XP_004561662.1 420 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial-like [Maylandia zebra]
GI:51230650 RefSeq XP_005740453.1 420 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial-like [Pundamilia nyererei]
GI:51230650 RefSeq XP_005936025.1 420 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial-like [Haplochromis burtoni]
GI:51230650 RefSeq XP_007244797.1 418 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial-like [Astyanax mexicanus]