Gene/Proteome Database (LMPD)

LMPD ID
LMP011868
Gene ID
448949
Species
Danio rerio (Zebrafish)
Gene Name
CCR4-NOT transcription complex, subunit 1
Gene Symbol
cnot1
Synonyms
kiaa1007l; cdc39-like; im:7141761; wu:fc58h04; zgc:152902
Alternate Names
CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1
Chromosome
25

Proteins

CCR4-NOT transcription complex subunit 1
Refseq ID NP_001073420
Protein GI 121582322
UniProt ID A1A5H6
mRNA ID NM_001079951
Length 2374
RefSeq Status PROVISIONAL
MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECVSLITKPNFISTLCYAIDNPLHYQKSLKPSPHLFTQLSKVLKLSKVQEVILGLALSNSSNADLRGFAAQFVKQKLPDLLRSYVDADLGGNQEGGFQDIAIEVLHLLLSHLLFGQKGSSGVGQEQIDAFLKTLCRDFPQERCPVVLAPLLYPDKRDILMDRILPDSGDLNKTMMESSLADFMQEVGYGFCASLEECRNIILQYGVREVTASQVARVLGMMARTHSGLSDGISLQTITNPVGGGGIWSDGKDKSDSSQAWNVEVLIDVVKEVNPNLNFKEVTYELDHPGFLIRDSKGLQIVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLLSPEVFCFADNPCHTVAIDTLKAPPEDDNREIATWKSLDLVESLLRLSEVGHYEQVKQLFSFPIKHCPDMLVLALLQISTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHSMAEWYMRGEQYDQAKLSRILDVAQDLKSLSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACVTFLKRRCPSIMGGLAPEKDQPKSAQLPPETLATMLACLQSCAGSVSQELSETILTMVANCSNVMNKARQPPPGVLPKGRAPSTSSLDAISPVQMDPLSAMGSLSLGVSSTSHTPSMQGFPSLQGSAFSNPQSPAKAFSNLPNPNPSTAFPGINPLSSQLQGPLSTSLSGIGSGLGMPTVSSDVFSARKMSTPGLNPPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIAHFLQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSLALAQAQAQSQPPKAPQPGQASTLVTTATTTTTAAKTTTITRPTAVGPKKDVPPSINTTNIDTLLVATDQTERIVEPPENVQEKIAFIFNNLSQSNMSQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFVKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILYTDLELKSLLLEAYVKGQQELLYVVPFVAKVLESSLRSVIFRPQNPWTMGIMNVLAELHQEHDLKLNLKFEIEVLCKNLSMDITDLKPGNLLRDKDKLKTLEEQLSAPKKETKPPEELLPIVTTDSVPFTAAPSTPATTTACTATGPPTPQFSYHDINVYALAGLAPHININVNIPLLQAHPQLKQCVRPAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESHMRVAAHHMMRNLTAGMAMITCREPLLMSIATNLKNSFAAALRAPTPQQREMMEEAAARIAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPMVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPSNDLSQPTGFLAQPMKQQAWPTDDVAHIYEKCISDLEQHLHAIPPALAMNPQTQAIRSLLEAVVMARNSRDGIAALGLLQKAVEGLLDATSGADPELLLSYRECHLLVLKALQDGRAYGPQWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKLLLVDERSVSHITEADLFHTIETLMRTSAHSRANAPEGLPQLMDVVRSNYEAMIDRHHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHPTTSPAIIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLIQDHDVRQTEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELNKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPSQFKKDLDSYLKTRSPVTFLSELRSNLQVSNEPGNRYNIQLINALVPYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANAEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWSHDFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS

Gene Information

Entrez Gene ID
448949
Gene Name
CCR4-NOT transcription complex, subunit 1
Gene Symbol
cnot1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030014 ISS:UniProtKB C CCR4-NOT complex
GO:0000932 ISS:UniProtKB C cytoplasmic mRNA processing body
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0030331 ISS:UniProtKB F estrogen receptor binding
GO:0042974 ISS:UniProtKB F retinoic acid receptor binding
GO:0031047 IEA:UniProtKB-KW P gene silencing by RNA
GO:0033147 ISS:UniProtKB P negative regulation of intracellular estrogen receptor signaling pathway
GO:0048387 ISS:UniProtKB P negative regulation of retinoic acid receptor signaling pathway
GO:0000122 ISS:UniProtKB P negative regulation of transcription from RNA polymerase II promoter
GO:0010606 ISS:UniProtKB P positive regulation of cytoplasmic mRNA processing body assembly
GO:1900153 ISS:UniProtKB P positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0060213 ISS:UniProtKB P positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0006417 IEA:UniProtKB-KW P regulation of translation
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
dre03018 RNA degradation
ko03018 RNA degradation

Domain Information

InterPro Annotations

Accession Description
IPR007196 CCR4-Not complex component, Not1, C-terminal
IPR024557 CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819

UniProt Annotations

Entry Information

Gene Name
CCR4-NOT transcription complex, subunit 1
Protein Entry
CNOT1_DANRE
UniProt ID
A1A5H6
Species
Zebrafish

Comments

Comment Type Description
Domain Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors. {ECO:0000250}.
Function Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity). {ECO:0000250}.
Similarity Belongs to the CNOT1 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Subunit Component of the CCR4-NOT complex. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011868 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
121582322 RefSeq NP_001073420 2374 CCR4-NOT transcription complex subunit 1

Identical Sequences to LMP011868 proteins

Reference Database Accession Length Protein Name
GI:121582322 GenBank AAI28656.1 2374 CCR4-NOT transcription complex, subunit 1 [Danio rerio]
GI:121582322 SwissProt A1A5H6.1 2374 RecName: Full=CCR4-NOT transcription complex subunit 1; AltName: Full=CCR4-associated factor 1 [Danio rerio]

Related Sequences to LMP011868 proteins

Reference Database Accession Length Protein Name
GI:121582322 RefSeq XP_007228425.1 2368 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X1 [Astyanax mexicanus]
GI:121582322 RefSeq XP_007228426.1 2360 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X2 [Astyanax mexicanus]
GI:121582322 RefSeq XP_008298939.1 2387 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X3 [Stegastes partitus]
GI:121582322 RefSeq XP_008298940.1 2386 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X4 [Stegastes partitus]
GI:121582322 RefSeq XP_008298941.1 2383 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X5 [Stegastes partitus]
GI:121582322 RefSeq XP_008298945.1 2376 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X8 [Stegastes partitus]