Gene/Proteome Database (LMPD)

LMPD ID
LMP011871
Gene ID
449649
Species
Danio rerio (Zebrafish)
Gene Name
galactosylceramidase a
Gene Symbol
galca
Synonyms
galc; galcl; zgc:92561; si:ch211-199l3.4
Alternate Names
galactocerebrosidase; GALCERase; galactosylceramidase like
Chromosome
20
EC Number
3.2.1.46

Proteins

galactocerebrosidase precursor
Refseq ID NP_001005921
Protein GI 54400350
UniProt ID Q5SNX7
mRNA ID NM_001005921
Length 660
RefSeq Status PROVISIONAL
MQTHNFLCIIFVILGCSAQFYVIDDRIGLGREFDGIGGLSGGGATSRLLVNYEEPYRSQILDYLFKPNFGASLHILKVEIGGDAQTTDGTEPSHMHSKDEGNFFRGYEWWLMKEAKKRNPNIKLIGLPWAFPGWVGYGTQWPYFFPNVTANYVITWVMGAKQHHNLDIDYIGIWNEKAFDPTYIKVLRDVLDRAGFTNIGIIAADGDWSIASAMLDDPYLNDAVEVIGVHYPGTNTVKEALLTERKLWSSEDYSTYNDDIGAGCWARILNQNYVNGKMTSTISWNVIASYYENLSFGRDGLMTAEEPWSGHYIVESPIWMTAHTTQFTQPGWFYLQTVGKLNHGGSYVALTDRKGNLTIIIETMTHEHSQCIRPPLPHFDVSPQIATFELKGSFAHLADLQVWYSKLDFKSGNGTLFRQLRPIRAHNGLLSLKLDVDEVFTITTVTTAQRGFYPEPPKSCPFPKNYTDDFTIDNPPFSEAPYFADQTGVFEYFRNTTDNSSHAFTLRQVVIERPVAWAKDADQTISIIGDYSWSDVNVSCDVFIETPKTGGVFLAARVDQGGESVRQAKGVFYWIYANGTYRVTNDIGGKGVLAEGLSGTKAGVWYTLTLSVKGYFATGSLNGFPLWKNAAVLEPKSGWAALGTLSFEYAQFDNFNVIAG

Gene Information

Entrez Gene ID
449649
Gene Name
galactosylceramidase a
Gene Symbol
galca
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IDA:ZFIN C lysosome
GO:0004336 ISS:UniProtKB F galactosylceramidase activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0006683 ISS:UniProtKB P galactosylceramide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dre04142 Lysosome
ko04142 Lysosome
dre01100 Metabolic pathways
dre00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013781 Glycoside hydrolase, catalytic domain
IPR001286 Glycoside hydrolase, family 59
IPR017853 Glycoside hydrolase superfamily

UniProt Annotations

Entry Information

Gene Name
galactosylceramidase a
Protein Entry
GALC_DANRE
UniProt ID
Q5SNX7
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity D-galactosyl-N-acylsphingosine + H(2)O = D- galactose + N-acylsphingosine.
Function Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. {ECO:0000250}.
Similarity Belongs to the glycosyl hydrolase 59 family. {ECO:0000305}.
Subcellular Location Lysosome {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011871 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54400350 RefSeq NP_001005921 660 galactocerebrosidase precursor

Identical Sequences to LMP011871 proteins

Reference Database Accession Length Protein Name
GI:54400350 GenBank AAH83517.1 660 Galactosylceramidase a [Danio rerio]

Related Sequences to LMP011871 proteins

Reference Database Accession Length Protein Name
GI:54400350 EMBL CDQ61947.1 660 unnamed protein product [Oncorhynchus mykiss]
GI:54400350 GenBank AHH39940.1 659 Galactocerebrosidase [Ictalurus punctatus]
GI:54400350 RefSeq XP_003459682.1 664 PREDICTED: galactocerebrosidase-like [Oreochromis niloticus]
GI:54400350 RefSeq XP_006632318.1 664 PREDICTED: galactocerebrosidase-like [Lepisosteus oculatus]
GI:54400350 RefSeq XP_007255486.1 664 PREDICTED: galactocerebrosidase-like [Astyanax mexicanus]
GI:54400350 SwissProt Q5SNX7.1 660 RecName: Full=Galactocerebrosidase; Short=GALCERase; AltName: Full=Galactosylceramidase; Flags: Precursor [Danio rerio]