Gene/Proteome Database (LMPD)

LMPD ID
LMP011901
Gene ID
492781
Species
Danio rerio (Zebrafish)
Gene Name
mevalonate (diphospho) decarboxylase a
Gene Symbol
mvda
Synonyms
mvd; zgc:100824
Alternate Names
diphosphomevalonate decarboxylase; MDDase; mevalonate (diphospho)decarboxylase; mevalonate pyrophosphate decarboxylase
Chromosome
11
EC Number
4.1.1.33

Proteins

diphosphomevalonate decarboxylase
Refseq ID NP_001007423
Protein GI 55925435
UniProt ID Q5U403
mRNA ID NM_001007422
Length 400
RefSeq Status PROVISIONAL
MSENILQDLEMVTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNGKEQDISHPRLQSCLLEIRRLAQRRKNTGDPASDVSNKVHICSVNNFPTAAGLASSAAGYACLVYTLSQLFNVEGELSGVARQGSGSACRSLYGGFVQWKLGEQSDGKDSIAEQVASELYWPELRVLILVVSAEQKSVGSTSGMHTSVETSHLLKYRADAVVPGRMEEMIRAIRLRDFPKFGELTMKDSNQFHAICLDTYPPIFYLNNISHQIISLVHRYNQYYGETRVAYTFDAGPNAVIYSLQDYLPEFVEVVRHFFPPEVNEEEFFKGLPVCPADLSEEMIRDINMKPTPNGIRYMISTKAGPGPRVVEDPNLHLLGADGLPKKSAV

Gene Information

Entrez Gene ID
492781
Gene Name
mevalonate (diphospho) decarboxylase a
Gene Symbol
mvda
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:InterPro C cytosol
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004163 IEA:UniProtKB-EC F diphosphomevalonate decarboxylase activity
GO:0006695 IEA:UniProtKB-UniPathway P cholesterol biosynthetic process
GO:0019287 IEA:InterPro P isopentenyl diphosphate biosynthetic process, mevalonate pathway

KEGG Pathway Links

KEGG Pathway ID Description
dre_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
dre01100 Metabolic pathways
dre00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029765 Diphosphomevalonate decarboxylase
IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
IPR006204 GHMP kinase N-terminal domain
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate (diphospho) decarboxylase a
Protein Entry
MVD1_DANRE
UniProt ID
Q5U403
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
Function Performs the first committed step in the biosynthesis of isoprenes. {ECO:0000250}.
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Similarity Belongs to the diphosphomevalonate decarboxylase family. {ECO:0000305}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011901 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
55925435 RefSeq NP_001007423 400 diphosphomevalonate decarboxylase

Identical Sequences to LMP011901 proteins

Reference Database Accession Length Protein Name
GI:55925435 GenBank AAH85325.1 400 Zgc:100824 [Danio rerio]
GI:55925435 SwissProt Q5U403.1 400 RecName: Full=Diphosphomevalonate decarboxylase; AltName: Full=Mevalonate (diphospho)decarboxylase; Short=MDDase; AltName: Full=Mevalonate pyrophosphate decarboxylase [Danio rerio]

Related Sequences to LMP011901 proteins

Reference Database Accession Length Protein Name
GI:55925435 EMBL CDQ87522.1 402 unnamed protein product [Oncorhynchus mykiss]
GI:55925435 GenBank AHH39284.1 401 Diphosphomevalonate decarboxylase [Ictalurus punctatus]
GI:55925435 RefSeq XP_004539436.1 402 PREDICTED: diphosphomevalonate decarboxylase-like [Maylandia zebra]
GI:55925435 RefSeq XP_005915248.1 402 PREDICTED: diphosphomevalonate decarboxylase-like [Haplochromis burtoni]
GI:55925435 RefSeq XP_007244091.1 404 PREDICTED: diphosphomevalonate decarboxylase [Astyanax mexicanus]
GI:55925435 RefSeq XP_008300019.1 402 PREDICTED: diphosphomevalonate decarboxylase [Stegastes partitus]