Gene/Proteome Database (LMPD)

LMPD ID
LMP011907
Gene ID
492810
Species
Danio rerio (Zebrafish)
Gene Name
major facilitator superfamily domain containing 2aa
Gene Symbol
mfsd2aa
Synonyms
NLS1-A; mfsd2a; zgc:101615
Alternate Names
sodium-dependent lysophosphatidylcholine symporter 1-A; sodium-dependent LPC symporter 1-A; major facilitator superfamily domain containing 2a; major facilitator superfamily domain-containing protein 2A-A
Chromosome
13

Proteins

sodium-dependent lysophosphatidylcholine symporter 1-A
Refseq ID NP_001007452
Protein GI 55925395
UniProt ID Q5U3U7
mRNA ID NM_001007451
Length 532
RefSeq Status PROVISIONAL
MARGEGAEQFSSGLLPTAKSVTQNEIKMVKLPKQQERKRALTVWSKVCFAIGGAPYQITGTALGFFLQIFLLDVAQLNPLNASVILFVGRAWDAVTDPTVGFLVSRTPWTRHGRMMPWILVSTIPAVLCYFLIWVVPPIEQGKMMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQRERDSATAYRMTVEVFGTVVGTAIQGQIVGMANTPCKNNTSPNNSSNDLIQSNNSHIPLKSNIFDERCAYMIASAVISLIYVVCAAVLFFGVREQDVQGELKAQKRVSFQKGLRLVMGHGPYVKLVLAFLFTSLAFMLLEGNFAVFIKYTLGFREDFQNILLVIMVSATVSIPMWQWFLCRFGKKTAVYIGITWAVPFMILVVSVNSSLIVSYIVSIAAGVSVGAAFLLPWSMLPDVVDDFKLQNPTSQGHEAIFYSFYVFFTKFASGVSLGVSTLALSFAGYETGVCVQSDSVNLTLKLLVSAAPVSLIALGLLIFMTYPIDEERREYNNKQLQLLLRNEEEEDEMEVLKPDITA

Gene Information

Entrez Gene ID
492810
Gene Name
major facilitator superfamily domain containing 2aa
Gene Symbol
mfsd2aa
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 ISS:UniProtKB C integral component of plasma membrane
GO:0005548 ISS:UniProtKB F phospholipid transporter activity
GO:0015293 ISS:UniProtKB F symporter activity
GO:0060856 ISS:UniProtKB P establishment of blood-brain barrier
GO:0015908 ISS:UniProtKB P fatty acid transport
GO:1990379 ISS:UniProtKB P lipid transport across blood brain barrier
GO:0015914 ISS:GOC P phospholipid transport
GO:0045056 ISS:UniProtKB P transcytosis
GO:0055085 ISS:GOC P transmembrane transport

Domain Information

InterPro Annotations

Accession Description
IPR016196 MFS_dom_general_subst_transpt

UniProt Annotations

Entry Information

Gene Name
major facilitator superfamily domain containing 2aa
Protein Entry
NLS1A_DANRE
UniProt ID
Q5U3U7
Species
Zebrafish

Comments

Comment Type Description
Function Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega- 3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). {ECO:0000250}.
Similarity Belongs to the major facilitator superfamily. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011907 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
55925395 RefSeq NP_001007452 532 sodium-dependent lysophosphatidylcholine symporter 1-A

Identical Sequences to LMP011907 proteins

Reference Database Accession Length Protein Name
GI:55925395 GenBank AAH85388.1 532 Major facilitator superfamily domain containing 2a [Danio rerio]
GI:55925395 SwissProt Q5U3U7.1 532 RecName: Full=Sodium-dependent lysophosphatidylcholine symporter 1-A; Short=NLS1-A; Short=Sodium-dependent LPC symporter 1-A; AltName: Full=Major facilitator superfamily domain-containing protein 2A-A [Danio rerio]

Related Sequences to LMP011907 proteins

Reference Database Accession Length Protein Name
GI:55925395 EMBL CDQ83985.1 527 unnamed protein product [Oncorhynchus mykiss]
GI:55925395 EMBL CDQ65922.1 526 unnamed protein product [Oncorhynchus mykiss]
GI:55925395 RefSeq XP_005157050.1 550 PREDICTED: sodium-dependent lysophosphatidylcholine symporter 1-A isoform X1 [Danio rerio]
GI:55925395 RefSeq XP_007247627.1 528 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like isoform X1 [Astyanax mexicanus]
GI:55925395 RefSeq XP_007247628.1 508 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like isoform X2 [Astyanax mexicanus]
GI:55925395 RefSeq XP_009305747.1 536 PREDICTED: sodium-dependent lysophosphatidylcholine symporter 1-A isoform X2 [Danio rerio]