Gene/Proteome Database (LMPD)

LMPD ID
LMP011931
Gene ID
541479
Species
Danio rerio (Zebrafish)
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase b
Gene Symbol
hmgcrb
Synonyms
hmgcr2; im:6912716; zgc:110746
Chromosome
21

Proteins

3-hydroxy-3-methylglutaryl-CoA reductase b
Refseq ID NP_001014314
Protein GI 62122765
UniProt ID Q58ER2
mRNA ID NM_001014292
Length 845
RefSeq Status PROVISIONAL
MMLSRLFRLHGLFVASHPWEVIVGTVAVTMCLMSMNAFAGNDQICGWNHQCPKVQEKIISGDMAILTITRCIAIIYIYIQFKNLRQLGSKYILGIAGLFTIFSSFVFSTVVVHFLGKELTGLNEALPFFLLLIDLSKACTLAKFALSSNSQEEVRENIAQGMAILGPTFTLDAVVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEEGNKPNPVTQRVKMIMSLVLALVHAHSRLKTESPAHNISSSDVVLPTSNMESDRSMSSVDLEQVITLSLALLLAAKYVFFEQAETESSLSIKTTVATPNCSLINRRGGEERCQRDSAPPKAIKGVNENKSEREAPDRSFSIGNPEDEERDKIQCRPVQECLAILKDPKRGAGFLSNAEVMALVESRGILGYRLEAVMESPERGVAIRREMLSGKLPDSSALENLPYKHYDYSKVVGSNCENVIGYVPVPVGVAGPLLLDGKEFHVPMATTEGCLVASTNRGCRAVTLSGGVSSRVLADGMTRGPVVQMPSACRAAEVKGWLESSEGFTEIKQAFDHTSRFARLDRLQVSLAGRNLYIRFQSQTGDAMGMNMLSKGTEQALGRLQERYPDMRLLAVSGNYCTDKKPAAVNWIHGRGKSTVCEAVIPARVVKEVLKSSTAALVELNISKNLVGSAMAGSIGGFNAHAANIVTAIYIACGQDPAQTVGSSNCITLMECVGTSGEDLYVSCTMPSLELGTIGGGTGLPAQHACLQMLGVGGASVQCPGENSRTLARIVCASVLAGELSLMAALAAGHLVQSHMTHNRSKVNLREPEGQPKEAS

Gene Information

Entrez Gene ID
541479
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase b
Gene Symbol
hmgcrb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:InterPro C integral component of membrane
GO:0050661 IEA:InterPro F NADP binding
GO:0004420 IEA:UniProtKB-EC F hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0001955 IMP:ZFIN P blood vessel maturation
GO:0015936 IEA:InterPro P coenzyme A metabolic process
GO:0003007 IMP:ZFIN P heart morphogenesis
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase b
Protein Entry
Q58ER2_DANRE
UniProt ID
Q58ER2
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
Similarity Belongs to the HMG-CoA reductase family.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP011931 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62122765 RefSeq NP_001014314 845 3-hydroxy-3-methylglutaryl-CoA reductase b

Identical Sequences to LMP011931 proteins

Reference Database Accession Length Protein Name
GI:62122765 GenBank AAH91792.1 845 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b [Danio rerio]

Related Sequences to LMP011931 proteins

Reference Database Accession Length Protein Name
GI:62122765 GenBank AAI17623.1 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a [Danio rerio]
GI:62122765 GenBank AAI55136.1 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a [Danio rerio]
GI:62122765 GenBank AHH37791.1 858 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Ictalurus punctatus]
GI:62122765 RefSeq XP_005165572.1 884 PREDICTED: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 [Danio rerio]
GI:62122765 RefSeq XP_007252844.1 873 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like [Astyanax mexicanus]
GI:62122765 RefSeq NP_001073446.2 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Danio rerio]