Gene/Proteome Database (LMPD)
LMPD ID
LMP011990
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
lysophosphatidylcholine acyltransferase 2
Gene Symbol
Synonyms
aytl1; zgc:112165
Alternate Names
lysophosphatidylcholine acyltransferase 2; LPCAT-2; lysoPAFAT; 1-AGPAT 11; LPC acyltransferase 2; acyltransferase like 1; acyltransferase-like 1; 1-AGP acyltransferase 11; lysoPC acyltransferase 2; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-alkylglycerophosphocholine O-acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Chromosome
7
EC Number
2.3.1.23
Proteins
| lysophosphatidylcholine acyltransferase 2 | |
|---|---|
| Refseq ID | NP_001018492 |
| Protein GI | 66472436 |
| UniProt ID | Q502J0 |
| mRNA ID | NM_001020656 |
| Length | 529 |
| RefSeq Status | PROVISIONAL |
| MPPPHRVFALPRQQSLLLPAVINPFVHDLSLSTADITKCFLLGIILVPLRAIFLLLVLLVMWPVSVIITFGQSLKGVVEPMTGWRRFLHRRVMTFLGRMYFFGMGFKVVVKGKKASTLEAPILAVAPHSSFFDAIACIESGLPSTVSRIESLEAPIFGRFLRCVQPVLVSRTDPDSRRNTIIEIERRAKSGGHWPQVLIFPEGTCTNRSCLITFKQGGFVPGVPVQPVLIRYPNKLDTVTWTWQGPKSARLLLLTLCQLCTTVEVEFLPPQVPTEMEKKCPLKFAQSVRAVMAKSLKLPVTDHTYEDCRLMIAAGELTLPMEAGLVEFTKISRKLELKWDNVKKELESFANIACSCKGGRITVEEFASFLKLPISPALQQLFALFDRNGDGTIDFREYVIGVTVLCRPANNEEVIQTAFKLFDIDEDNCITQEEFSSLLRSALGVCDLDVHSLFREIDADGSGHITYDEFRSFALNHPEYAKLFTTYIELQRYQGLQGDETDFDSAFSHCCTAAYDEYQEDSASDKKDD | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidylcholine acyltransferase 2
Gene Symbol
Species
Danio rerio
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005811 | IEA:UniProtKB-KW | C | lipid particle |
| GO:0003841 | IEA:UniProtKB-EC | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0047184 | IEA:UniProtKB-EC | F | 1-acylglycerophosphocholine O-acyltransferase activity |
| GO:0047192 | IEA:UniProtKB-EC | F | 1-alkylglycerophosphocholine O-acetyltransferase activity |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0008654 | IEA:UniProtKB-KW | P | phospholipid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| dre00565 | Ether lipid metabolism |
| dre00564 | Glycerophospholipid metabolism |
| dre01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6176787 | Acyl chain remodelling of PC |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lysophosphatidylcholine acyltransferase 2
Protein Entry
PCAT2_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Domain | The HXXXXD motif is essential for acyltransferase activity. {ECO:0000250}. |
| Function | Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. May catalyze the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn- glycero-3-phosphocholine. May also cataylze the conversion of as well 1-O-alkyl-sn-glycero-3-phosphocholine to 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine and 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (By similarity). {ECO:0000250}. |
| Pathway | Lipid metabolism; phospholipid metabolism. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}. |
| Similarity | Contains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011990 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 66472436 | RefSeq | NP_001018492 | 529 | lysophosphatidylcholine acyltransferase 2 |
Identical Sequences to LMP011990 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:66472436 | GenBank | AAH95679.1 | 529 | Zgc:112165 [Danio rerio] |
| GI:66472436 | SwissProt | Q502J0.1 | 529 | RecName: Full=Lysophosphatidylcholine acyltransferase 2; Short=LPC acyltransferase 2; Short=LPCAT-2; Short=LysoPC acyltransferase 2; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 11; Short=1-AGP acyltransferase 11; Short=1-AGPAT 11; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=1-alkylglycerophosphocholine O-acetyltransferase; AltName: Full=Acyltransferase-like 1 [Danio rerio] |
Related Sequences to LMP011990 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:66472436 | GenBank | ACN11048.1 | 524 | Lysophosphatidylcholine acyltransferase 2 [Salmo salar] |
| GI:66472436 | RefSeq | NP_001167384.1 | 524 | Lysophosphatidylcholine acyltransferase 2 [Salmo salar] |
| GI:66472436 | RefSeq | XP_004539724.1 | 525 | PREDICTED: lysophosphatidylcholine acyltransferase 2-like [Maylandia zebra] |
| GI:66472436 | RefSeq | XP_005169036.1 | 529 | PREDICTED: lysophosphatidylcholine acyltransferase 2 isoform X1 [Danio rerio] |
| GI:66472436 | RefSeq | XP_007246943.1 | 525 | PREDICTED: lysophosphatidylcholine acyltransferase 2 [Astyanax mexicanus] |
| GI:66472436 | RefSeq | XP_008280165.1 | 525 | PREDICTED: lysophosphatidylcholine acyltransferase 2 [Stegastes partitus] |