Gene/Proteome Database (LMPD)

LMPD ID
LMP012018
Gene ID
555969
Species
Danio rerio (Zebrafish)
Gene Name
lysophosphatidylcholine acyltransferase 1
Gene Symbol
lpcat1
Synonyms
zgc:158232; si:dkey-261i16.4
Alternate Names
lysophosphatidylcholine acyltransferase 1; aytl2; LPCAT-1; lysoPAFAT; LPC acyltransferase 1; acyltransferase-like 2; lysoPC acyltransferase 1; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Chromosome
19
EC Number
2.3.1.23

Proteins

lysophosphatidylcholine acyltransferase 1
Refseq ID NP_001037806
Protein GI 121583846
UniProt ID Q1LWG4
mRNA ID NM_001044341
Length 517
RefSeq Status PROVISIONAL
MRFPNRKLHTAVNGGDSGVSTHFRNPFVHELRFTTLQKLKIAVMTVTLFPVRLLFAAFMMLLAWPFAFVATVGRSENAVEPLSWWRWLVDLALKAIMRAMWFSGGFHWVRVKGRPALPSEAPILTMAPHSSYFDAIPVTMTMASIVMKAESKDIPVWGTLIKFIRPVFVSRSDQDSRRKTVEEIKRRASSNGEWPQIMIFPEGTCTNRSCLIAFKPGAFIPGVPVQPVVLRYPNELDTISWTWQGPGAFKILWLTLCQLHNFVEIEYLPTYTPSEEEKKDPALFASNVRRIMAKALGLPIIDYSFEDCQLAMAKGPLRLPKHTCLLEFARLVRLLGLKTKVTDEVLREEASSARQLCGRRLDMEGFAQYLHQPMTEAVQDIFSLFEEHGMMDVREYVIALSVVCRPFRYLDTVKLAFRMFEAQEDGAIVEDELTVILKTALGVGDLAVSELFRAIDSQDKGKITFDDLCSFMEKCPDLVEQYHCLCESISQHSRESTSSSNGFCADFSPRNHSKKQD

Gene Information

Entrez Gene ID
555969
Gene Name
lysophosphatidylcholine acyltransferase 1
Gene Symbol
lpcat1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 ISS:UniProtKB C Golgi apparatus
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IEA:UniProtKB-KW C lipid particle
GO:0047184 ISS:UniProtKB F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192 IEA:UniProtKB-EC F 1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0008654 ISS:UniProtKB P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dre00565 Ether lipid metabolism
dre00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6176787 Acyl chain remodelling of PC
6176788 Acyl chain remodelling of PG

Domain Information

InterPro Annotations

Accession Description
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
lysophosphatidylcholine acyltransferase 1
Protein Entry
PCAT1_DANRE
UniProt ID
Q1LWG4
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
Domain The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. {ECO:0000250}.
Function Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; phospholipid metabolism.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Similarity Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012018 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
121583846 RefSeq NP_001037806 517 lysophosphatidylcholine acyltransferase 1

Identical Sequences to LMP012018 proteins

Reference Database Accession Length Protein Name
GI:121583846 GenBank AAI29168.1 517 Lysophosphatidylcholine acyltransferase 1 [Danio rerio]

Related Sequences to LMP012018 proteins

Reference Database Accession Length Protein Name
GI:121583846 GenBank AFP97560.1 498 lysophosphatidylcholine acyltransferase 1, partial [Sparus aurata]
GI:121583846 RefSeq XP_005170093.1 517 PREDICTED: lysophosphatidylcholine acyltransferase 1 isoform X1 [Danio rerio]
GI:121583846 RefSeq XP_006635996.1 522 PREDICTED: lysophosphatidylcholine acyltransferase 1-like [Lepisosteus oculatus]
GI:121583846 RefSeq XP_007249482.1 545 PREDICTED: lysophosphatidylcholine acyltransferase 1 [Astyanax mexicanus]
GI:121583846 RefSeq XP_009292489.1 474 PREDICTED: lysophosphatidylcholine acyltransferase 1 isoform X2 [Danio rerio]
GI:121583846 SwissProt Q1LWG4.1 517 RecName: Full=Lysophosphatidylcholine acyltransferase 1; Short=LPC acyltransferase 1; Short=LPCAT-1; Short=LysoPC acyltransferase 1; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=1-alkylglycerophosphocholine O-acetyltransferase; AltName: Full=Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Short=Acetyl-CoA:lyso-PAF acetyltransferase; Short=Lyso-PAF acetyltransferase; Short=LysoPAFAT; AltName: Full=Acyltransferase-like 2 [Danio rerio]