Gene/Proteome Database (LMPD)

LMPD ID
LMP012053
Gene ID
559054
Species
Danio rerio (Zebrafish)
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase a
Gene Symbol
hmgcra
Synonyms
hmgcr1; hmgcr1a; zgc:136576; si:ch211-129a6.5
Chromosome
5

Proteins

3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Refseq ID NP_001073446
Protein GI 642945614
UniProt ID Q1ECY4
mRNA ID NM_001079977
Length 884
RefSeq Status VALIDATED
MLTRLFRIHGLFVASHPWEVIVATVTLTICMMSMNMFTGNNQICGWNFDCPKLDEQILSSDIIILTITRCIAIVYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKACALAKFALSSNSQDEVRENIAKGMAVLGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEEDNKPNPVTQRVKMIMSLGLVMVHAHSRWIADPASSDGTLDLPEVGMSLNENLPKRIEPDMPLWHFYLSRMISMDIEQVITLGLALFLAVKYIFFEQVEMESTLSLKVPTPSSMLTQKWSPDQCCRKEIPYSTKLDKPPTPPPVVTKEERDLVIRPLPAPKEPEQKSTFVLGEDETQENTHVPEPVMSLPAEPRPVEDCLSILKNPDMGARYLSDEEVIVLVNSKHIPAYKLEAMMETPERGVMIRRKMLSPKFPEPSTLSCLPYKDYDYSKVMGTCCENVIGYMPVPVGVAGPLLLDGKQFQVPMATTEGCLVASTNRGCRAIALAGGASSRVLADGMTRGPVVRFPSACQAAEVKAWLESPEGFKTIKEAFDQTSRFARLEKLLIGLASRNLYIRFQSRTGDAMGMNMISKGTEQALARLKEEFPELQVLAVSGNYCTDKKPAAINWIEGRGKSVVCETTIPAKVVKEILKTSTEALVDVNISKNLVGSAMAGSIGGYNAHAANIVAAIYIACGQDPAQTVGSSNCITLMEASGATGEDLYISCTMPSIELGTVGGGTNLPPQQACLKMLGVLGASQECPGENARQLAKVVCATVLAGELSLMSALAAGHLVKSHMTHNRSKVNLQEAPGTCTKQAS

Gene Information

Entrez Gene ID
559054
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase a
Gene Symbol
hmgcra
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:InterPro C integral component of membrane
GO:0050661 IEA:InterPro F NADP binding
GO:0004420 IEA:UniProtKB-EC F hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0015936 IEA:InterPro P coenzyme A metabolic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process
GO:0007519 IMP:ZFIN P skeletal muscle tissue development

Domain Information

InterPro Annotations

Accession Description
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase a
Protein Entry
Q1ECY4_DANRE
UniProt ID
Q1ECY4
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
Similarity Belongs to the HMG-CoA reductase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012053 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
642945614 RefSeq NP_001073446 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Identical Sequences to LMP012053 proteins

Reference Database Accession Length Protein Name
GI:642945614 GenBank AAI55136.1 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a [Danio rerio]
GI:642945614 RefSeq XP_005165572.1 884 PREDICTED: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 [Danio rerio]

Related Sequences to LMP012053 proteins

Reference Database Accession Length Protein Name
GI:642945614 EMBL CAM13174.1 893 novel protein similar to vertebrate 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) [Danio rerio]
GI:642945614 GenBank AAR02862.2 887 HMG-CoA reductase [Dicentrarchus labrax]
GI:642945614 GenBank AAI17623.1 884 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a [Danio rerio]
GI:642945614 GenBank AHI87506.1 884 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Gobiocypris rarus]
GI:642945614 RefSeq XP_003974515.1 886 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like [Takifugu rubripes]
GI:642945614 RefSeq XP_007243979.1 885 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Astyanax mexicanus]