Gene/Proteome Database (LMPD)

LMPD ID
LMP012099
Gene ID
563201
Species
Danio rerio (Zebrafish)
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
pi4kb
Synonyms
pik4cb; zgc:152715
Alternate Names
phosphatidylinositol 4-kinase beta; PI4Kbeta; PI4K-beta; PI4KIII-beta; ptdIns 4-kinase beta; phosphatidylinositol 4-kinase III beta; catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide
Chromosome
16
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-kinase beta
Refseq ID NP_001030149
Protein GI 116175243
UniProt ID Q49GP3
mRNA ID NM_001034977
Length 835
RefSeq Status PROVISIONAL
MGDTELELSPTHLEELQKSPSTSTTSSLSLPSSPSSGPHPLTSSSPSTSEGLPTSSPPLDVISEGLGELSLVIDTEVAKKACQEVLQKVKFLKGDGEVSSASSEPILANGTAHPEANDGGQPPKISEEEVEPIKSVRRRQKNNSSKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFSFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYVVYRCRQSINFSLQCAWLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPSSQRIRREVPQPPPPYPPPLHHGPGMSEHSLSPSKRTHQRSKSDATVSISLSSNLKRTASNPKVETSQDEPVRLTPQREFIKSLMGIGKRLATLPTKEQKTQGLISELSLLNHKLPARVWLPTAAFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFETSSVPVRIPETQIRSTRSVENLPDCGITPDQRASSFSTVPNYDNDDEAWSVDDIGELQVELPEIHTNSCDNISQFSVDSITSQESKEPIFIAAGDIRRRLSEQLAHTPTTFRKDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAYQVLKQLQIIWEQERVPLWIKPYKILVISSDSGMIEPVVNAVSIHQVKKQSQLLLLDYFRQEHGNFNTEEFLTAQRNFVQSCAGYCLICYLLQVKDRHNGNILLDSEGHIIHIDFGFILSSSPRNLGFETSAFKLTSEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMEKVIQIVEIMQQGSQLPCFHGSSTIRNLKERFHMNLTEEQLQVLVEQMVDGSMRSITTKLYDGFQYLTNGIM

Gene Information

Entrez Gene ID
563201
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
pi4kb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0004430 IEA:UniProtKB-EC F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 IEA:InterPro P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
dre00562 Inositol phosphate metabolism
dre_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
dre01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6176822 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Protein Entry
PI4KB_DANRE
UniProt ID
Q49GP3
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). {ECO:0000250}.
Sequence Caution Sequence=ACH92118.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012099 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116175243 RefSeq NP_001030149 835 phosphatidylinositol 4-kinase beta

Identical Sequences to LMP012099 proteins

Reference Database Accession Length Protein Name
GI:116175243 GenBank AAI24585.1 835 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Danio rerio]

Related Sequences to LMP012099 proteins

Reference Database Accession Length Protein Name
GI:116175243 GenBank AAY16568.1 835 phosphatidylinositol 4-kinase III beta [Danio rerio]
GI:116175243 GenBank ACH92118.1 847 catalytic phosphatidylinositol 4-kinase beta [Danio rerio]
GI:116175243 GenBank AAI71616.1 850 Pi4kb protein [Danio rerio]
GI:116175243 RefSeq XP_005158276.1 850 PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Danio rerio]
GI:116175243 RefSeq XP_005158277.1 848 PREDICTED: phosphatidylinositol 4-kinase beta isoform X2 [Danio rerio]
GI:116175243 SwissProt Q49GP3.2 835 RecName: Full=Phosphatidylinositol 4-kinase beta; Short=PI4K-beta; Short=PI4Kbeta; Short=PtdIns 4-kinase beta [Danio rerio]