Gene/Proteome Database (LMPD)

LMPD ID
LMP012109
Gene ID
564750
Species
Danio rerio (Zebrafish)
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
pi4k2b
Synonyms
zgc:158305
Alternate Names
phosphatidylinositol 4-kinase type 2-beta; PI4KII-beta; pi4kII beta; phosphatidylinositol 4-kinase II beta; phosphatidylinositol 4-kinase type II-beta
Chromosome
1
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-kinase type 2-beta
Refseq ID NP_001038950
Protein GI 113865947
UniProt ID Q49GP5
mRNA ID NM_001045485
Length 501
RefSeq Status PROVISIONAL
MMAECDPTDGEPGNGSGDSTPETNFLSSEVPAVLFEKTRSAPSLGLSLNPGAAVRISDSTESVLTELEADGSGEEALLLPGPAGSLSPRAGKEKRTRRNMLSSSSDNLASPGNSSGEFNHFPEDPEFGEIIQRAEQAIENGVFPERISQGSSGSYFVKDPKGKIIGVFKPKSEEPYGHLNPKWTKYFHKVCCPCCFGRGCLIPNQGYLSEAAASLVDQKLGLWIVPKTKVVHLASETFHYNAIDRAKSRGKKYALEKVPKVGRRFHRVGLPPKVGSFQLFVEGYHEADFWLRKFEAEPLPENMRKQLQSQFERLVVLDYVIRNTDRGNDNWLIKYEKPGDGELTEKESEWTDPKDSAIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVAFSQETRDLVLSRISDMNFVQDLCEDLYEMFRTDKGFDKTMFEKQMSVMRGQILNLTQALKDGKSPIQLVQMPRVVVERSRSGGQGRVVQLGNAFTQTFHCKRPFFTSW

Gene Information

Entrez Gene ID
564750
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
pi4k2b
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0004430 IEA:UniProtKB-EC F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0033339 IMP:ZFIN P pectoral fin development

KEGG Pathway Links

KEGG Pathway ID Description
dre00562 Inositol phosphate metabolism
dre_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
dre01100 Metabolic pathways
dre04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase type 2 beta
Protein Entry
P4K2B_DANRE
UniProt ID
Q49GP5
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Function Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). {ECO:0000250}.
Similarity Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012109 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
113865947 RefSeq NP_001038950 501 phosphatidylinositol 4-kinase type 2-beta

Identical Sequences to LMP012109 proteins

Reference Database Accession Length Protein Name
GI:113865947 GenBank AAY16566.1 501 phosphatidylinositol 4-kinase II beta [Danio rerio]
GI:113865947 GenBank AAI29196.1 501 Zgc:158305 [Danio rerio]
GI:113865947 SwissProt Q49GP5.1 501 RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Danio rerio]

Related Sequences to LMP012109 proteins

Reference Database Accession Length Protein Name
GI:113865947 RefSeq XP_003448041.1 510 PREDICTED: phosphatidylinositol 4-kinase type 2-beta-like [Oreochromis niloticus]
GI:113865947 RefSeq XP_004538924.1 510 PREDICTED: phosphatidylinositol 4-kinase type 2-beta-like [Maylandia zebra]
GI:113865947 RefSeq XP_005735906.1 510 PREDICTED: phosphatidylinositol 4-kinase type 2-beta-like [Pundamilia nyererei]
GI:113865947 RefSeq XP_005944931.1 510 PREDICTED: phosphatidylinositol 4-kinase type 2-beta-like [Haplochromis burtoni]
GI:113865947 RefSeq XP_006790660.1 510 PREDICTED: phosphatidylinositol 4-kinase type 2-beta-like [Neolamprologus brichardi]
GI:113865947 RefSeq XP_008276152.1 508 PREDICTED: phosphatidylinositol 4-kinase type 2-beta [Stegastes partitus]