Gene/Proteome Database (LMPD)
Proteins
| lysyl oxidase homolog 2A precursor | |
|---|---|
| Refseq ID | NP_001092714 |
| Protein GI | 149773460 |
| UniProt ID | F1QQC3 |
| mRNA ID | NM_001099244 |
| Length | 737 |
| RefSeq Status | PROVISIONAL |
| MAVSSALCVFGLLVLVQAQSELQQPKIELRLAGDKRKHYEGRLEVFYNNEWGTVCDDDFSIEAAHVACRQLGFLGAVAWSPSAKFGQGEGRIWLDNVHCTGRENSLAACPSNGFGVSDCRHSEDVGVICNQKRIPGHRFINIMNNNIETLEERVEEIRIRPISSHLKRIPITEGYVEVKEWGKWRQICDEEWTPLNSRVVCGMYGFPGEKNYNNKVYRSLSMRKKKNYWGFLVNCTGNEAHMSSCRLGKALEPKRNGTCGRGLPVVVSCVPGRAFAPSSSIGFRKAYRPEQPLVRLRGGANVGEGRVEVLKNGVWGTVCDDNWNLKAATVVCRELGFGSAKEALTGAKLGQGMGPVHMNEVECSGFEKSLTDCYFNNDALGCSHEEDAAVRCNVPAMGFQKRIRLSGGRNPFEGRVEVLAEKNGSLVWGTVCSENWGIIEAMVVCRQLGLGFASHAFQETWYWAGDANADNVVMSGVRCSGTEMSLPQCLHHGKHINCPKGGGRFAAGVSCSDTAPDLVLNAQLVEQTTYLEDRPMYALQCALEENCLSSTARKNDHSSYRRLLRFSSQIHNVGQSDFRPKLGYHAWTWHECHRHYHSMEVFTHYDLLSLNGTKVAEGHKASFCLEDTHCDEGISKRYHCANFGEQGITVGCWDTYRHDIDCQWIDVTDVKPGDYIFQVVINPNYDVAESDYTNNVMKCKCRYDGYRIWTYSCHIGGSRSSDMDEYSGMSNQLNHLR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005604 | ISS:UniProtKB | C | basement membrane |
| GO:0005694 | IEA:UniProtKB-KW | C | chromosome |
| GO:0016020 | IEA:InterPro | C | membrane |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005507 | IEA:InterPro | F | copper ion binding |
| GO:0004720 | IEA:UniProtKB-EC | F | protein-lysine 6-oxidase activity |
| GO:0005044 | IEA:InterPro | F | scavenger receptor activity |
| GO:0016568 | IEA:UniProtKB-KW | P | chromatin modification |
| GO:0030199 | ISS:UniProtKB | P | collagen fibril organization |
| GO:0043542 | ISS:UniProtKB | P | endothelial cell migration |
| GO:0001935 | ISS:UniProtKB | P | endothelial cell proliferation |
| GO:0001837 | ISS:UniProtKB | P | epithelial to mesenchymal transition |
| GO:0045892 | ISS:UniProtKB | P | negative regulation of transcription, DNA-templated |
| GO:0032332 | ISS:UniProtKB | P | positive regulation of chondrocyte differentiation |
| GO:0001666 | ISS:UniProtKB | P | response to hypoxia |
| GO:0002040 | IMP:UniProtKB | P | sprouting angiogenesis |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2). |
| Cofactor | Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250}; |
| Cofactor | Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence={ECO:0000250}; Note=Contains 1 lysine tyrosylquinone. {ECO:0000250}; |
| Developmental Stage | Expression increases between 20 and 48 hours after fertilization and is detected in sprouting intersegmental vessels. {ECO:0000269|PubMed:21835952}. |
| Function | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When nuclear, acts as a transcription corepressor and probably specifically mediates deamination of histone H3. Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. {ECO:0000250, ECO:0000269|PubMed:21835952}. |
| Ptm | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250}. |
| Similarity | Belongs to the lysyl oxidase family. {ECO:0000305}. |
| Similarity | Contains 4 SRCR domains. {ECO:0000255|PROSITE- ProRule:PRU00196}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromatin (By similarity). It is unclear how loxl2a is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012116 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 149773460 | RefSeq | NP_001092714 | 737 | lysyl oxidase homolog 2A precursor |
Identical Sequences to LMP012116 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:149773460 | GenBank | ABM86967.1 | 737 | lysyl oxidase-like 2a [Danio rerio] |
Related Sequences to LMP012116 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:149773460 | EMBL | CDQ67131.1 | 748 | unnamed protein product [Oncorhynchus mykiss] |
| GI:149773460 | RefSeq | XP_003441453.1 | 740 | PREDICTED: lysyl oxidase homolog 2A-like [Oreochromis niloticus] |
| GI:149773460 | RefSeq | XP_007255010.1 | 736 | PREDICTED: lysyl oxidase homolog 2A-like [Astyanax mexicanus] |
| GI:149773460 | RefSeq | XP_008293000.1 | 743 | PREDICTED: lysyl oxidase homolog 2A-like [Stegastes partitus] |
| GI:149773460 | RefSeq | XP_009303525.1 | 737 | PREDICTED: lysyl oxidase homolog 2A isoform X1 [Danio rerio] |
| GI:149773460 | SwissProt | F1QQC3.1 | 737 | RecName: Full=Lysyl oxidase homolog 2A; AltName: Full=Lysyl oxidase-like protein 2A; Flags: Precursor [Danio rerio] |