Gene/Proteome Database (LMPD)

LMPD ID
LMP012149
Gene ID
569040
Species
Danio rerio (Zebrafish)
Gene Name
phospholipase C, delta 3a
Gene Symbol
plcd3a
Synonyms
zgc:158396
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; PLC-delta-3-A; DrPLC-delta 3A; phospholipase C-delta-3-A; phosphoinositide phospholipase C delta-3-A; phosphoinositide phospholipase C-delta-3-A; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3-A
Chromosome
3
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A
Refseq ID NP_001092893
Protein GI 150378473
UniProt ID A5D6R3
mRNA ID NM_001099423
Length 784
RefSeq Status PROVISIONAL
MLGRKKNPETVQTESKSVESKTHDPLRRLGVLDDEDVLLMLQGSKMMKVRSQRWRKDRRLKLLEDCVTVWCESSKTSRKSNRQQTFSVTEVECVREGCQSECLRRMTDLVPEKNCFTVVFRGGRKSLDLCCHTQEEAERWVRGIRTLKDRVSNMSQKEKLDHWIRGYLRRADQNQDGKMSYDEVKHLLQLINIDLNEQYARTLFKKCDRSCDGRLDHVEIEEFCREMMRRPELDAVFRHYSGNGCVLTTLELRDFLGDQGEDASLVHAKSLIQTFELNDWAQKNLFMTQNGFTMYMLSKENDVFNPDHTHVYQDMSKPLAHYYISSSHNTYLTKDQVTSASSTEPYIRALNQGCRCVELDCWDGDKGEPIIYHGHTLTSKVLFKEVIETIAQYAFKASPYPLILSLENHCSVEQQAIMAQQLQSILGKKLLAKPLSDLPLKQLPSPEELKGRILLKGKKLNGLLGKTESWTSFTNSSDEESVAGGNKKESKKDLARSASTKLSPELSDLVVYCQSVPFSGFETANQRPPSVITSFSENEALKLIKDSGKLFVRNNSRQLSRIYPSAQRLQSSNFDPQDMWNAGCQMVALNFQTPGEQMDLNQGRFLPNGRCGYVLKPEFLCDPKSDFDPENTGGGPGHIPTQLTIRVISAQQLPKINTDKPNSIVDPQVWVEIHGVSIDKARAKTQRIDNNGFNPRWDCTVSFQLQLPELALVRFMVEDHDHKSKNDFIGQFTLPFTSLRTGYRHVHLLKADGSTLSPATLFIHVKVVRRGVHIKTVSERIGKA

Gene Information

Entrez Gene ID
569040
Gene Name
phospholipase C, delta 3a
Gene Symbol
plcd3a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0001525 IEA:InterPro P angiogenesis
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0042127 IEA:InterPro P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
dre04020 Calcium signaling pathway
dre00562 Inositol phosphate metabolism
dre_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

REACTOME Pathway Links

REACTOME Pathway ID Description
6176835 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR028406 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, delta 3a
Protein Entry
PLD3A_DANRE
UniProt ID
A5D6R3
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. {ECO:0000250};
Domain The C2 domain is a Ca(2+)-dependent membrane-targeting module. {ECO:0000250}.
Domain The PH domain mediates interaction with the surface membrane by binding to PIP2. {ECO:0000250}.
Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity). {ECO:0000250}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012149 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
150378473 RefSeq NP_001092893 784 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A

Identical Sequences to LMP012149 proteins

Reference Database Accession Length Protein Name
GI:150378473 GenBank AAI39850.1 784 Plcd3a protein [Danio rerio]
GI:150378473 SwissProt A5D6R3.1 784 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; AltName: Full=Phosphoinositide phospholipase C-delta-3-A; AltName: Full=Phospholipase C-delta-3-A; Short=PLC-delta-3-A [Danio rerio]

Related Sequences to LMP012149 proteins

Reference Database Accession Length Protein Name
GI:150378473 GenBank ACA05827.1 787 phospholipase C delta 3A [Paralichthys olivaceus]
GI:150378473 GenBank AHH42417.1 769 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [Ictalurus punctatus]
GI:150378473 RefSeq XP_003964868.1 784 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [Takifugu rubripes]
GI:150378473 RefSeq XP_007234540.1 790 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [Astyanax mexicanus]
GI:150378473 RefSeq XP_008289006.1 790 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [Stegastes partitus]
GI:150378473 RefSeq XP_008327683.1 790 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [Cynoglossus semilaevis]