Gene/Proteome Database (LMPD)

LMPD ID
LMP012169
Gene ID
571388
Species
Danio rerio (Zebrafish)
Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Gene Symbol
hmgcll1
Synonyms
zgc:172206
Alternate Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1
Chromosome
13
EC Number
4.1.3.4

Proteins

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
Refseq ID NP_001103870
Protein GI 160333724
UniProt ID A8WG57
mRNA ID NM_001110400
Length 335
RefSeq Status PROVISIONAL
MGNVSSAVKHCLSYETFLRDYPWLPRLLWEEKCSELPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVAQMADHTAVLKGIKRSPDVRYPVLTPNIQGFQAAVAAGANEVAVFGSASETFSRKNINCSIEESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLGDTIGVGTAGSMAEMLSDVLTEVPAGALAVHCHDTYGQALPNILIALQMGVSVVDASVAGLGGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGDFICKALNRKTNSKVSQATRNN

Gene Information

Entrez Gene ID
571388
Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Gene Symbol
hmgcll1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0016020 ISS:UniProtKB C membrane
GO:0048471 ISS:UniProtKB C perinuclear region of cytoplasm
GO:0004419 ISS:UniProtKB F hydroxymethylglutaryl-CoA lyase activity
GO:0046872 ISS:UniProtKB F metal ion binding
GO:0046951 ISS:UniProtKB P ketone body biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR000891 Pyruvate carboxyltransferase

UniProt Annotations

Entry Information

Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Protein Entry
HMGC2_DANRE
UniProt ID
A8WG57
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate.
Cofactor Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250}; Note=Divalent metal cations. {ECO:0000250};
Function Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000250}.
Pathway Metabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1.
Similarity Belongs to the HMG-CoA lyase family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012169 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160333724 RefSeq NP_001103870 335 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Identical Sequences to LMP012169 proteins

Reference Database Accession Length Protein Name
GI:160333724 GenBank AAI54588.1 335 Zgc:172206 protein [Danio rerio]
GI:160333724 SwissProt A8WG57.1 335 RecName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; AltName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1 [Danio rerio]

Related Sequences to LMP012169 proteins

Reference Database Accession Length Protein Name
GI:160333724 EMBL CDQ61328.1 346 unnamed protein product [Oncorhynchus mykiss]
GI:160333724 RefSeq XP_003441173.1 341 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [Oreochromis niloticus]
GI:160333724 RefSeq XP_005737201.1 341 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [Pundamilia nyererei]
GI:160333724 RefSeq XP_008320324.1 336 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic [Cynoglossus semilaevis]
GI:160333724 RefSeq XP_009305327.1 330 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1 [Danio rerio]
GI:160333724 RefSeq XP_009305328.1 287 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X2 [Danio rerio]