Gene/Proteome Database (LMPD)

LMPD ID
LMP012251
Gene ID
793294
Species
Danio rerio (Zebrafish)
Gene Name
sphingomyelin phosphodiesterase 4
Gene Symbol
smpd4
Synonyms
zgc:66367; wu:fb22d05; wu:fi25e10
Alternate Names
sphingomyelin phosphodiesterase 4; nSMase3; nSMase-3; neutral sphingomyelinase 3; neutral sphingomyelinase III
Chromosome
21
EC Number
3.1.4.12

Proteins

sphingomyelin phosphodiesterase 4
Refseq ID NP_998520
Protein GI 47087013
UniProt ID Q6PFJ7
mRNA ID NM_213355
Length 791
RefSeq Status PROVISIONAL
MAASALQQPSYLLANLKADWTNKPLHQRCHELCKIIDDYPAKELHAIFPWLVECVFGSLDGILTGWNLRFLQARSAEYSIAMEFLDPSGPMMKLVYKLQAEEYKYEFPISYLPGPIKSSIHAGVLPDCPLFHNKIQFPMSGLLFLNPFEYYMFNFASSLIAPKNYPQGQHGSSSDSAYFVLVDTYLKYFLPTEGNVPPSPFSDTRGTVASPAPRSTNVPYVGYGGHSTSLLKRHITHQSSVNADPAAQEIWRSETLLQVFVEMWLHHYSLEMYQKLQSPQVKEPFMPSEEHVLVVRLLVKHLHTFSSSLKPESISSSPSAHSHSSPLEELKRVVVQRFVQQKLYVFLQHCFGHWPLDASFRAVLETWLSYIQPWRYTGDKNNTQTDGPNRTVPDKWASFVQENLLLYTKLFQGFLNRAMRTDLVNAKNALMVFRVAKVFAQPSLSEMIQKGEQLFLEPEHAILQRHNRVFLTPSHGGSFLSARQPMGTDNVFKVKSHVYSLEGQDCQYNLMFGPDQRKNVLKLIQIIAQARQTAKRISDHSTEMAANNSFLSWFGVGSPDHNSTFTGGEMDEMGGEGVKKTHEFLDKALDYLCQIFRLNAGQLSQLISNVASVDNNGASKQLPDCIPSENGLVLTDLGRLQIINGLRRFEIEYQGDPELQPIRSYENAFLVRLLFQISSFINERLGEHMEVLCSRQDFLGSVGRHYLSSSSAVVEQRRKSPVTRQMRDRPQRARLSLRALASYRTLLTLLLLYMLFALLSFGLFSSTGLILIISFLYELLSNFFHEKLKTH

Gene Information

Entrez Gene ID
793294
Gene Name
sphingomyelin phosphodiesterase 4
Gene Symbol
smpd4
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0050290 IEA:InterPro F sphingomyelin phosphodiesterase D activity

KEGG Pathway Links

KEGG Pathway ID Description
dre01100 Metabolic pathways
dre00600 Sphingolipid metabolism
ko00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR024129 Sphingomyelin phosphodiesterase 4

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 4
Protein Entry
NSMA3_DANRE
UniProt ID
Q6PFJ7
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012251 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47087013 RefSeq NP_998520 791 sphingomyelin phosphodiesterase 4

Identical Sequences to LMP012251 proteins

Reference Database Accession Length Protein Name
GI:47087013 GenBank AAH57525.1 791 Sphingomyelin phosphodiesterase 4 [Danio rerio]
GI:47087013 SwissProt Q6PFJ7.1 791 RecName: Full=Sphingomyelin phosphodiesterase 4; AltName: Full=Neutral sphingomyelinase 3; Short=nSMase-3; Short=nSMase3; AltName: Full=Neutral sphingomyelinase III [Danio rerio]

Related Sequences to LMP012251 proteins

Reference Database Accession Length Protein Name
GI:47087013 GenBank AAI71455.1 791 Smpd4 protein [Danio rerio]
GI:47087013 RefSeq XP_004559062.1 794 PREDICTED: sphingomyelin phosphodiesterase 4-like isoform X6 [Maylandia zebra]
GI:47087013 RefSeq XP_004559064.1 790 PREDICTED: sphingomyelin phosphodiesterase 4-like isoform X8 [Maylandia zebra]
GI:47087013 RefSeq XP_005928981.1 790 PREDICTED: sphingomyelin phosphodiesterase 4-like isoform X6 [Haplochromis burtoni]
GI:47087013 RefSeq XP_008278707.1 798 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X3 [Stegastes partitus]
GI:47087013 RefSeq XP_008278708.1 796 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X4 [Stegastes partitus]