Gene/Proteome Database (LMPD)
LMPD ID
LMP012285
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Gene Symbol
Synonyms
zgc:77526
Alternate Names
peroxisomal bifunctional enzyme; PBE; PBFE; l-pbe; DKEYP-30D5.2; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Chromosome
9
EC Number
4.2.1.17
Proteins
| peroxisomal bifunctional enzyme | |
|---|---|
| Refseq ID | NP_996951 |
| Protein GI | 46309503 |
| UniProt ID | Q6NYL3 |
| mRNA ID | NM_207068 |
| Length | 718 |
| RefSeq Status | PROVISIONAL |
| MARYELVKRSVALITLTNPPVNALSSAVRHAISKTMERALSDPKVTAVVICGENGRFCGGADIREFAGPLRGPPLVPLLDAIEAGEKPVVAAIEGVALGGGFELALVCHYRIAHYKARLGLPEVTLGILPAAGGTQRLPRLIGIPAALELITTGRHVSAQEALKLGMVDQVTEQNTCEVALEFALKAVGKPLSSRRLSMLTTPCPPGLDGIFEAATMQVQKKARGVMAPLACVQAVRAATLPYSEGIKREGELMATLFSSGQAQALQYSFFAQRTAEKWTLPSGAQWNNSKPREIQSAAVIGLGTMGRGIVVSLARVGISVIAVESEKKLLETGRQMVIGMLERDAKRRGVSASLNLLKFSLSLQDLKDVDLVIEAVFEDMALKKQIFRELSRVCRPATLLCSNTSGLDVDALADVTDRPQLVAGMHFFSPAHVMKLLEVVCGPRSSKEAIATAMSLGKRMGKVSVAVGNCPGFVGNRMLMPYLEQATFLLEEGATPQQIDKALEDFGFAMGVFRMSDLAGLDVGWRVRKESGLTGPDVDPKDPPRRRQGRKYCPIPDMVCQQGRFGQKTGRGWYMYDKPGDTNAKPDPLIQNLLETYRSRYGIQPRKITDQEIIERCLFALANEGFRILKDKIAGQPEDIDVIYLFGYGFPRHRGGPMFYASMVGLERVLERLEYYHHALPDVPHLEPSPLLKKLVARGSPPIQKWREHIKSMHSHL | |
Gene Information
Entrez Gene ID
Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Gene Symbol
Species
Danio rerio
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005777 | IEA:UniProtKB-KW | C | peroxisome |
| GO:0003857 | IEA:UniProtKB-EC | F | 3-hydroxyacyl-CoA dehydrogenase activity |
| GO:0050662 | IEA:InterPro | F | coenzyme binding |
| GO:0004165 | IEA:UniProtKB-EC | F | dodecenoyl-CoA delta-isomerase activity |
| GO:0004300 | IEA:UniProtKB-EC | F | enoyl-CoA hydratase activity |
| GO:0006635 | IEA:UniProtKB-UniPathway | P | fatty acid beta-oxidation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| dre01200 | Carbon metabolism |
| dre_M00013 | Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA |
| dre03320 | PPAR signaling pathway |
| dre04146 | Peroxisome |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal |
| IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding |
| IPR006180 | 3-hydroxyacyl-CoA dehydrogenase, conserved site |
| IPR008927 | 6-phosphogluconate dehydrogenase, C-terminal-like |
| IPR029045 | ClpP/crotonase-like domain |
| IPR001753 | Crotonase_core_superfam |
| IPR013328 | Dehydrogenase, multihelical |
| IPR018376 | Enoyl-CoA hydratase/isomerase, conserved site |
| IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Protein Entry
ECHP_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O. |
| Catalytic Activity | (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA. |
| Catalytic Activity | (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| Pathway | Lipid metabolism; fatty acid beta-oxidation. |
| Similarity | In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family. {ECO:0000305}. |
| Similarity | In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}. |
| Subcellular Location | Peroxisome {ECO:0000250}. |
| Subunit | Monomer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012285 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 46309503 | RefSeq | NP_996951 | 718 | peroxisomal bifunctional enzyme |
Identical Sequences to LMP012285 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:46309503 | EMBL | CBG04593.1 | 718 | unnamed protein product [Danio rerio] |
| GI:46309503 | EMBL | CBV18115.1 | 718 | unnamed protein product [Danio rerio] |
| GI:46309503 | GenBank | AAH66545.1 | 718 | Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [Danio rerio] |
| GI:46309503 | GenBank | AGX96000.1 | 718 | Sequence 72260 from patent US 8541208 |
| GI:46309503 | SwissProt | Q6NYL3.1 | 718 | RecName: Full=Peroxisomal bifunctional enzyme; Short=PBE; Short=PBFE; Includes: RecName: Full=Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase [Danio rerio] |
Related Sequences to LMP012285 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:46309503 | GenBank | ACI33880.1 | 716 | Peroxisomal bifunctional enzyme [Salmo salar] |
| GI:46309503 | GenBank | AHH40708.1 | 719 | Peroxisomal bifunctional enzyme [Ictalurus punctatus] |
| GI:46309503 | RefSeq | NP_001133776.1 | 716 | Peroxisomal bifunctional enzyme [Salmo salar] |
| GI:46309503 | RefSeq | XP_005723415.1 | 719 | PREDICTED: peroxisomal bifunctional enzyme-like isoform X2 [Pundamilia nyererei] |
| GI:46309503 | RefSeq | XP_005723416.1 | 719 | PREDICTED: peroxisomal bifunctional enzyme-like isoform X3 [Pundamilia nyererei] |
| GI:46309503 | RefSeq | XP_006788640.1 | 719 | PREDICTED: peroxisomal bifunctional enzyme-like [Neolamprologus brichardi] |