Gene/Proteome Database (LMPD)

LMPD ID
LMP012285
Gene ID
100000859
Species
Danio rerio (Zebrafish)
Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Gene Symbol
ehhadh
Synonyms
zgc:77526
Alternate Names
peroxisomal bifunctional enzyme; PBE; PBFE; l-pbe; DKEYP-30D5.2; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Chromosome
9
EC Number
4.2.1.17

Proteins

peroxisomal bifunctional enzyme
Refseq ID NP_996951
Protein GI 46309503
UniProt ID Q6NYL3
mRNA ID NM_207068
Length 718
RefSeq Status PROVISIONAL
MARYELVKRSVALITLTNPPVNALSSAVRHAISKTMERALSDPKVTAVVICGENGRFCGGADIREFAGPLRGPPLVPLLDAIEAGEKPVVAAIEGVALGGGFELALVCHYRIAHYKARLGLPEVTLGILPAAGGTQRLPRLIGIPAALELITTGRHVSAQEALKLGMVDQVTEQNTCEVALEFALKAVGKPLSSRRLSMLTTPCPPGLDGIFEAATMQVQKKARGVMAPLACVQAVRAATLPYSEGIKREGELMATLFSSGQAQALQYSFFAQRTAEKWTLPSGAQWNNSKPREIQSAAVIGLGTMGRGIVVSLARVGISVIAVESEKKLLETGRQMVIGMLERDAKRRGVSASLNLLKFSLSLQDLKDVDLVIEAVFEDMALKKQIFRELSRVCRPATLLCSNTSGLDVDALADVTDRPQLVAGMHFFSPAHVMKLLEVVCGPRSSKEAIATAMSLGKRMGKVSVAVGNCPGFVGNRMLMPYLEQATFLLEEGATPQQIDKALEDFGFAMGVFRMSDLAGLDVGWRVRKESGLTGPDVDPKDPPRRRQGRKYCPIPDMVCQQGRFGQKTGRGWYMYDKPGDTNAKPDPLIQNLLETYRSRYGIQPRKITDQEIIERCLFALANEGFRILKDKIAGQPEDIDVIYLFGYGFPRHRGGPMFYASMVGLERVLERLEYYHHALPDVPHLEPSPLLKKLVARGSPPIQKWREHIKSMHSHL

Gene Information

Entrez Gene ID
100000859
Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Gene Symbol
ehhadh
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0003857 IEA:UniProtKB-EC F 3-hydroxyacyl-CoA dehydrogenase activity
GO:0050662 IEA:InterPro F coenzyme binding
GO:0004165 IEA:UniProtKB-EC F dodecenoyl-CoA delta-isomerase activity
GO:0004300 IEA:UniProtKB-EC F enoyl-CoA hydratase activity
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
dre01200 Carbon metabolism
dre_M00013 Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA
dre04146 Peroxisome
dre03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR013328 Dehydrogenase, multihelical
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Protein Entry
ECHP_DANRE
UniProt ID
Q6NYL3
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic Activity (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Catalytic Activity (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family. {ECO:0000305}.
Similarity In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012285 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46309503 RefSeq NP_996951 718 peroxisomal bifunctional enzyme

Identical Sequences to LMP012285 proteins

Reference Database Accession Length Protein Name
GI:46309503 EMBL CBG04593.1 718 unnamed protein product [Danio rerio]
GI:46309503 EMBL CBV18115.1 718 unnamed protein product [Danio rerio]
GI:46309503 GenBank AAH66545.1 718 Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [Danio rerio]
GI:46309503 GenBank AGX96000.1 718 Sequence 72260 from patent US 8541208
GI:46309503 SwissProt Q6NYL3.1 718 RecName: Full=Peroxisomal bifunctional enzyme; Short=PBE; Short=PBFE; Includes: RecName: Full=Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase [Danio rerio]

Related Sequences to LMP012285 proteins

Reference Database Accession Length Protein Name
GI:46309503 GenBank ACI33880.1 716 Peroxisomal bifunctional enzyme [Salmo salar]
GI:46309503 GenBank AHH40708.1 719 Peroxisomal bifunctional enzyme [Ictalurus punctatus]
GI:46309503 RefSeq NP_001133776.1 716 Peroxisomal bifunctional enzyme [Salmo salar]
GI:46309503 RefSeq XP_005723415.1 719 PREDICTED: peroxisomal bifunctional enzyme-like isoform X2 [Pundamilia nyererei]
GI:46309503 RefSeq XP_005723416.1 719 PREDICTED: peroxisomal bifunctional enzyme-like isoform X3 [Pundamilia nyererei]
GI:46309503 RefSeq XP_006788640.1 719 PREDICTED: peroxisomal bifunctional enzyme-like [Neolamprologus brichardi]