Gene/Proteome Database (LMPD)

LMPD ID
LMP012311
Gene ID
100034753
Species
Danio rerio (Zebrafish)
Gene Name
retinoic acid receptor, gamma b
Gene Symbol
rargb
Synonyms
RARgamma-B
Chromosome
11

Proteins

retinoic acid receptor gamma-B
Refseq ID NP_001076779
Protein GI 133922573
UniProt ID A2T928
mRNA ID NM_001083310
Length 489
RefSeq Status PROVISIONAL
MRDVFREATPMTCRSPLPDLRDMMEKLTVFEPTIDSTVETQSTSSEEMIPSSPSPPPPPRVYKPCFVCQDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCQINKVTRNRCQYCRLRKCFEVGMSKEAVRNDRNKKKKDVKEEVVLPESYELSGELEELVNKVSKAHRETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELSTKCIIKIVEFAKRLPGFTSLTIADQITLLKSACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPHRVDQLQEPLLEALKIYARRRRPNKPHMFPRMLMKVTDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEIFEDSSDSNDSGAAAVVPAPNIKRMGQRQAAWVKGERPEWVRGRRRGSKSRYKAGFKAGKARSRDSPDNNGEIRQGDERSEMSVRAEQDFALE

Gene Information

Entrez Gene ID
100034753
Gene Name
retinoic acid receptor, gamma b
Gene Symbol
rargb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003708 IEA:InterPro F retinoic acid receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0071907 IMP:ZFIN P determination of digestive tract left/right asymmetry
GO:0061371 IMP:ZFIN P determination of heart left/right asymmetry
GO:0003140 IMP:ZFIN P determination of left/right asymmetry in lateral mesoderm
GO:0071910 IMP:ZFIN P determination of liver left/right asymmetry
GO:0035469 IMP:ZFIN P determination of pancreatic left/right asymmetry
GO:0035622 IMP:ZFIN P intrahepatic bile duct development
GO:0030514 IMP:ZFIN P negative regulation of BMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003078 Retinoic acid receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoic acid receptor, gamma b
Protein Entry
A2T928_DANRE
UniProt ID
A2T928
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage Expressed both maternally and zygotically. Expressed ubiquitously throughout gastrulation. At the tailbud stage, expressed at higher levels in the anterior and tailbud. Also expressed in migrating cranial neural crest cells.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development. {ECO:0000250, ECO:0000269|PubMed:18929555}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012311 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
133922573 RefSeq NP_001076779 489 retinoic acid receptor gamma-B

Identical Sequences to LMP012311 proteins

Reference Database Accession Length Protein Name
GI:133922573 GenBank ABM89228.1 489 retinoic acid receptor gamma b [Danio rerio]
GI:133922573 SwissProt A2T928.1 489 RecName: Full=Retinoic acid receptor gamma-B; Short=RAR-gamma-B; AltName: Full=Nuclear receptor subfamily 1 group B member 3-B [Danio rerio]

Related Sequences to LMP012311 proteins

Reference Database Accession Length Protein Name
GI:133922573 RefSeq XP_005739631.1 494 PREDICTED: retinoic acid receptor gamma-A-like isoform X2 [Pundamilia nyererei]
GI:133922573 RefSeq XP_005739632.1 494 PREDICTED: retinoic acid receptor gamma-A-like isoform X3 [Pundamilia nyererei]
GI:133922573 RefSeq XP_007248415.1 492 PREDICTED: retinoic acid receptor gamma-A-like isoform X1 [Astyanax mexicanus]
GI:133922573 RefSeq XP_007248416.1 491 PREDICTED: retinoic acid receptor gamma-A-like isoform X2 [Astyanax mexicanus]
GI:133922573 RefSeq XP_008305204.1 490 PREDICTED: retinoic acid receptor gamma-like isoform X1 [Stegastes partitus]
GI:133922573 RefSeq XP_008305205.1 483 PREDICTED: retinoic acid receptor gamma-A-like isoform X2 [Stegastes partitus]