Gene/Proteome Database (LMPD)

LMPD ID
LMP012345
Gene ID
4041
Species
Homo sapiens (Human)
Gene Name
low density lipoprotein receptor-related protein 5
Gene Symbol
LRP5
Synonyms
HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2;
Chromosome
11
Map Location
11q13.4
Summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
View orthologs and multiple alignments for LRP5

Proteins

low-density lipoprotein receptor-related protein 5 isoform 1 precursor
Refseq ID NP_002326
Protein GI 119709832
UniProt ID O75197
mRNA ID NM_002335
Length 1615
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
sig_peptide: 1..31 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3094 peptide sequence: MEAAPPGPPWPLLLLLLLLLALCGCPAPAAA mat_peptide: 32..1615 product: Low-density lipoprotein receptor-related protein 5 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O75197.2) calculated_mol_wt: 176070 peptide sequence: SPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
low-density lipoprotein receptor-related protein 5 isoform 2
Refseq ID NP_001278831
Protein GI 631790829
UniProt ID O75197
mRNA ID NM_001291902
Length 1034
MKDERTEDVMLAAALPAVLGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

Gene Information

Entrez Gene ID
4041
Gene Name
low density lipoprotein receptor-related protein 5
Gene Symbol
LRP5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0043235 IDA:BHF-UCL C receptor complex
GO:0015026 IBA:RefGenome F coreceptor activity
GO:0042813 IBA:RefGenome F Wnt-activated receptor activity
GO:0017147 IBA:RefGenome F Wnt-protein binding
GO:0060612 IMP:BHF-UCL P adipose tissue development
GO:0060033 IEA:Ensembl P anatomical structure regression
GO:0009952 IBA:RefGenome P anterior/posterior pattern specification
GO:1902262 IEA:Ensembl P apoptotic process involved in patterning of blood vessels
GO:0048539 IMP:BHF-UCL P bone marrow development
GO:0060349 IMP:BHF-UCL P bone morphogenesis
GO:0046849 IBA:RefGenome P bone remodeling
GO:0060444 IBA:RefGenome P branching involved in mammary gland duct morphogenesis
GO:0060070 IDA:BHF-UCL P canonical Wnt signaling pathway
GO:0060764 IEA:Ensembl P cell-cell signaling involved in mammary gland development
GO:0042074 IEA:Ensembl P cell migration involved in gastrulation
GO:0042632 IMP:BHF-UCL P cholesterol homeostasis
GO:0008203 IEA:Ensembl P cholesterol metabolic process
GO:0048596 IBA:RefGenome P embryonic camera-type eye morphogenesis
GO:0042733 IEA:Ensembl P embryonic digit morphogenesis
GO:0030326 IBA:RefGenome P embryonic limb morphogenesis
GO:0060059 IBA:RefGenome P embryonic retina morphogenesis in camera-type eye
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0035426 IEA:Ensembl P extracellular matrix-cell signaling
GO:0001702 IBA:RefGenome P gastrulation with mouth forming second
GO:0006007 IMP:BHF-UCL P glucose catabolic process
GO:0045668 IMP:BHF-UCL P negative regulation of osteoblast differentiation
GO:0071901 IMP:BHF-UCL P negative regulation of protein serine/threonine kinase activity
GO:0002076 IBA:RefGenome P osteoblast development
GO:0008284 IDA:BHF-UCL P positive regulation of cell proliferation
GO:0045600 IMP:BHF-UCL P positive regulation of fat cell differentiation
GO:0002053 IMP:BHF-UCL P positive regulation of mesenchymal cell proliferation
GO:0045840 IDA:BHF-UCL P positive regulation of mitosis
GO:0033690 IEA:Ensembl P positive regulation of osteoblast proliferation
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 IDA:BHF-UCL P positive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0042981 IEA:Ensembl P regulation of apoptotic process
GO:0008217 IMP:BHF-UCL P regulation of blood pressure
GO:0046850 IEA:Ensembl P regulation of bone remodeling
GO:0060828 IMP:BHF-UCL P regulation of canonical Wnt signaling pathway
GO:0061178 IBA:RefGenome P regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043434 IEA:Ensembl P response to peptide hormone
GO:0061304 IMP:BHF-UCL P retinal blood vessel morphogenesis
GO:0060042 IMP:BHF-UCL P retina morphogenesis in camera-type eye
GO:0035019 IEA:Ensembl P somatic stem cell maintenance
GO:0016055 IDA:BHF-UCL P Wnt signaling pathway
GO:0044332 IDA:BHF-UCL P Wnt signaling pathway involved in dorsal/ventral axis specification

KEGG Pathway Links

KEGG Pathway ID Description
hsa04310 Wnt signaling pathway
ko04310 Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_200610 disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125 Disease
REACT_228096 misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_200643 negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_200716 regulation of FZD by ubiquitination
REACT_228188 RNF mutants show enhanced WNT signaling and proliferation
REACT_11045 Signaling by Wnt
REACT_228331 Signaling by WNT in cancer
REACT_111102 Signal Transduction
REACT_200777 TCF dependent signaling in response to WNT
REACT_228279 XAV939 inhibits tankyrase, stabilizing AXIN

Domain Information

InterPro Annotations

Accession Description
IPR000742 Epidermal growth factor-like domain
IPR000033 LDLR class B repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR017049 Low density lipoprotein receptor-related protein, 5/6
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein 5
UniProt ID
O75197
Species
Human

Comments

Comment Type Description
Disease Endosteal hyperostosis, Worth type (WENHY) [MIM:144750]: An autosomal dominant sclerosing bone dysplasia clinically characterized by elongation of the mandible, increased gonial angle, flattened forehead, and the presence of a slowly enlarging osseous prominence of the hard palate (torus palatinus). Serum calcium, phosphorus and alkaline phosphatase levels are normal. Radiologically, it is characterized by early thickening of the endosteum of long bones, the skull and of the mandible. With advancing age, the trabeculae of the metaphysis become thickened. WENHY becomes clinically and radiologically evident by adolescence, does not cause deformity except in the skull and mandible, and is not associated with bone pain or fracture. Affected patients have normal height, proportion, intelligence and longevity Note=The disease is caused by mutations affecting the gene represented in this entry.
Disease High bone mass trait (HBM) [MIM:601884]: Rare phenotype characterized by exceptionally dense bones. HBM individuals show otherwise a completely normal skeletal structure and no other unusual clinical findings. {ECO:0000269|PubMed:11741193, ECO:0000269|PubMed:12015390, ECO:0000269|PubMed:15824861}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Disease Osteopetrosis, autosomal dominant 1 (OPTA1) [MIM:607634]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTA1 is an autosomal dominant form characterized by generalized osteosclerosis most pronounced in the cranial vault. Patients are often asymptomatic, but some suffer from pain and hearing loss. It appears to be the only type of osteopetrosis not associated with an increased fracture rate Note=The disease is caused by mutations affecting the gene represented in this entry.
Disease Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:15824851, ECO:0000269|PubMed:16234968}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease Osteoporosis-pseudoglioma syndrome (OPPG) [MIM:259770]: A disease characterized by congenital or infancy-onset blindness and severe juvenile-onset osteoporosis and spontaneous fractures. Additional clinical manifestations may include microphthalmos, abnormalities of the iris, lens or vitreous, cataracts, short stature, microcephaly, ligamental laxity, mental retardation and hypotonia. {ECO:0000269|PubMed:11719191, ECO:0000269|PubMed:16252235, ECO:0000269|PubMed:16679074, ECO:0000269|PubMed:17437160, ECO:0000269|PubMed:18602879}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Disease Van Buchem disease 2 (VBCH2) [MIM:607636]: VBCH2 is an autosomal dominant sclerosing bone dysplasia characterized by cranial osteosclerosis, thickened calvaria and cortices of long bones, enlarged mandible and normal serum alkaline phosphatase levels Note=The disease is caused by mutations affecting the gene represented in this entry.
Disease Vitreoretinopathy, exudative 4 (EVR4) [MIM:601813]: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. {ECO:0000269|PubMed:15024691, ECO:0000269|PubMed:15346351, ECO:0000269|PubMed:15981244, ECO:0000269|PubMed:16929062, ECO:0000269|PubMed:19324841, ECO:0000269|PubMed:20340138, ECO:0000269|PubMed:24715757}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
Interaction Q6IMN6:CAPRIN2; NbExp=3; IntAct=EBI-2466421, EBI-6918449;
Polymorphism Genetic variations in LRP5 define the bone mineral density quantitative trait locus 1 (BMND1) [MIM:601884]. Variance in bone mineral density influences bone mass and contributes to size determination in the general population.
Ptm Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1
Similarity Belongs to the LDLR family
Similarity Contains 20 LDL-receptor class B repeats
Similarity Contains 3 LDL-receptor class A domains
Similarity Contains 4 EGF-like domains
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum Note=Chaperoned to the plasma membrane by MESD
Subunit Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling (By similarity). Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1. {ECO:0000250, ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15143163, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:15908424, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17488095, ECO:0000269|PubMed:19746449, ECO:0000269|PubMed:20393562}.
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LRP5ID44282ch11q13.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP012345 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
119709832 RefSeq NP_002326 1615 low-density lipoprotein receptor-related protein 5 isoform 1 precursor
631790829 RefSeq NP_001278831 1034 low-density lipoprotein receptor-related protein 5 isoform 2

Identical Sequences to LMP012345 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012345 proteins

Reference Database Accession Length Protein Name