Gene/Proteome Database (LMPD)
LMPD ID
LMP012352
Gene ID
Species
Homo sapiens (Human)
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Synonyms
DP2; DL1R; CD294; CRTH2; GPR44;
Chromosome
11
Map Location
11q12-q13.3
Summary
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Orthologs
Proteins
| prostaglandin D2 receptor 2 | |
|---|---|
| Refseq ID | NP_004769 |
| Protein GI | 153791424 |
| UniProt ID | Q9Y5Y4 |
| mRNA ID | NM_004778 |
| Length | 395 |
| MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | IDA:UniProtKB | F | G-protein coupled receptor activity |
| GO:0004956 | IDA:UniProtKB | F | prostaglandin D receptor activity |
| GO:0004958 | IEA:Ensembl | F | prostaglandin F receptor activity |
| GO:0001785 | IEA:Ensembl | F | prostaglandin J receptor activity |
| GO:0007193 | IEA:Ensembl | P | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| GO:0019722 | IDA:UniProtKB | P | calcium-mediated signaling |
| GO:0006935 | IDA:UniProtKB | P | chemotaxis |
| GO:0007186 | IDA:UniProtKB | P | G-protein coupled receptor signaling pathway |
| GO:0006955 | TAS:ProtInc | P | immune response |
| GO:0045745 | IEA:Ensembl | P | positive regulation of G-protein coupled receptor protein signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_14828 | Class A/1 (Rhodopsin-like receptors) |
| REACT_18352 | Eicosanoid ligand-binding receptors |
| REACT_19231 | G alpha (i) signalling events |
| REACT_19184 | GPCR downstream signaling |
| REACT_21340 | GPCR ligand binding |
| REACT_18425 | Prostanoid ligand receptors |
| REACT_14797 | Signaling by GPCR |
| REACT_111102 | Signal Transduction |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
| Ptm | Phosphorylated |
| Sequence Caution | Sequence=AAD21055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAD21055.1; Type=Frameshift; Positions=375; Evidence= ; |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein Note=Internalized receptors colocalized with RAB11A |
| Tissue Specificity | Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269|PubMed:11168006, ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225, ECO:0000269|PubMed:9973380}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012352 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 153791424 | RefSeq | NP_004769 | 395 | prostaglandin D2 receptor 2 |
Identical Sequences to LMP012352 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP012352 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|