Gene/Proteome Database (LMPD)

LMPD ID
LMP012354
Gene ID
23205
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
ACSBG1
Synonyms
BG; BG1; BGM; LPD; GR-LACS;
Chromosome
15
Map Location
15q23-q24
EC Number
6.2.1.3
Summary
The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACSBG1

Proteins

long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1
Refseq ID NP_055977
Protein GI 27477105
UniProt ID Q96GR2
mRNA ID NM_015162
Length 724
MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHALELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQEQKM
long-chain-fatty-acid--CoA ligase ACSBG1 isoform 2
Refseq ID NP_001186306
Protein GI 313747580
UniProt ID Q96GR2
mRNA ID NM_001199377
Length 720
MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHALELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQYYLLARRAAKGFLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQEQKM

Gene Information

Entrez Gene ID
23205
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
ACSBG1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HGNC C cytoplasm
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:HGNC F long-chain fatty acid-CoA ligase activity
GO:0031957 IDA:HGNC F very long-chain fatty acid-CoA ligase activity
GO:0001676 IDA:HGNC P long-chain fatty acid metabolic process
GO:0042552 NAS:HGNC P myelination
GO:0001552 IEA:Ensembl P ovarian follicle atresia
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0000038 IDA:HGNC P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
ko04920 Adipocytokine signaling pathway
hsa00061 Fatty acid biosynthesis
ko00061 Fatty acid biosynthesis
hsa00071 Fatty acid degradation
ko00071 Fatty acid degradation
hsa01212 Fatty acid metabolism
ko01212 Fatty acid metabolism
hsa01100 Metabolic pathways
hsa03320 PPAR signaling pathway
ko03320 PPAR signaling pathway
M00086 beta-Oxidation, acyl-CoA synthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5143 fatty acid activation
PWY66-387 fatty acid alpha-oxidation II
FAO-PWY fatty acid beta-oxidation I
FAO-PWY fatty acid beta-oxidation I
PWY66-391 fatty acid beta-oxidation VI (peroxisome)
PWY-6000 gamma-linolenate biosynthesis II (animals)
PWY-5972 stearate biosynthesis I (animals)

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase bubblegum family member 1
UniProt ID
Q96GR2
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids
Sequence Caution Sequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily
Subcellular Location Cytoplasm Cytoplasmic vesicle {ECO:0000250}. Microsome Endoplasmic reticulum
Tissue Specificity Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012354 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27477105 RefSeq NP_055977 724 long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1
313747580 RefSeq NP_001186306 720 long-chain-fatty-acid--CoA ligase ACSBG1 isoform 2

Identical Sequences to LMP012354 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012354 proteins

Reference Database Accession Length Protein Name