Gene/Proteome Database (LMPD)

LMPD ID
LMP012361
Gene ID
Species
Homo sapiens (Human)
Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Gene Symbol
Synonyms
SELI; SEPI;
Chromosome
2
Map Location
2p23.3
EC Number
2.7.8.1
Summary
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Orthologs

Proteins

ethanolaminephosphotransferase 1
Refseq ID NP_277040
Protein GI 50083289
UniProt ID Q9C0D9
mRNA ID NM_033505
Length 397
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFRSYKNNTLKLNSVYEAMVPLFSPCLLFILSTAWILWSPSDILELHPRVFYFMVGTAFANSTCQLIVCQMSSTRCPTLNWLLVPLFLVVLVVNLGVASYVESILLYTLTTAFTLAHIHYGVRVVKQLSSHFQIYPFSLRKPNSDULGMEEKNIGL

Gene Information

Entrez Gene ID
Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004307 IEA:UniProtKB-EC F ethanolaminephosphotransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006646 TAS:Reactome P phosphatidylethanolamine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00565 Ether lipid metabolism
ko00565 Ether lipid metabolism
hsa00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY4FS-6 phosphatidylethanolamine biosynthesis II

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_111217 Metabolism
REACT_22258 Metabolism of lipids and lipoproteins
REACT_120870 Phospholipid metabolism
REACT_120919 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014472 Choline/ethanolamine phosphotransferase

UniProt Annotations

Entry Information

Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
UniProt ID
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=1.8 uM for CDP-ethanolamine ; Vmax=76.3 pmol/min/mg enzyme with CDP-ethanolamine as substrate ;
Catalytic Activity CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Sequence Caution Sequence=BAB21815.1; Type=Erroneous termination; Positions=387; Note=Translated as Sec.; Evidence= ;
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular Location Membrane ; Multi-pass membrane protein
Tissue Specificity Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe

Identical and Related Proteins

Unique RefSeq proteins for LMP012361 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50083289 RefSeq NP_277040 397 ethanolaminephosphotransferase 1

Identical Sequences to LMP012361 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012361 proteins

Reference Database Accession Length Protein Name