Gene/Proteome Database (LMPD)
LMPD ID
LMP012361
Gene ID
Species
Homo sapiens (Human)
Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Gene Symbol
Synonyms
SELI; SEPI;
Chromosome
2
Map Location
2p23.3
EC Number
2.7.8.1
Summary
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
ethanolaminephosphotransferase 1 | |
---|---|
Refseq ID | NP_277040 |
Protein GI | 50083289 |
UniProt ID | Q9C0D9 |
mRNA ID | NM_033505 |
Length | 397 |
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFRSYKNNTLKLNSVYEAMVPLFSPCLLFILSTAWILWSPSDILELHPRVFYFMVGTAFANSTCQLIVCQMSSTRCPTLNWLLVPLFLVVLVVNLGVASYVESILLYTLTTAFTLAHIHYGVRVVKQLSSHFQIYPFSLRKPNSDULGMEEKNIGL |
Gene Information
Entrez Gene ID
Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0004307 | IEA:UniProtKB-EC | F | ethanolaminephosphotransferase activity |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
GO:0006646 | TAS:Reactome | P | phosphatidylethanolamine biosynthetic process |
GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
hsa00565 | Ether lipid metabolism |
ko00565 | Ether lipid metabolism |
hsa00564 | Glycerophospholipid metabolism |
ko00564 | Glycerophospholipid metabolism |
hsa01100 | Metabolic pathways |
M00092 | Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE |
BIOCYC Pathway Links
BIOCYC Pathway ID | Description |
---|---|
PWY4FS-6 | phosphatidylethanolamine biosynthesis II |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_121401 | Glycerophospholipid biosynthesis |
REACT_111217 | Metabolism |
REACT_22258 | Metabolism of lipids and lipoproteins |
REACT_120870 | Phospholipid metabolism |
REACT_120919 | Synthesis of PE |
Domain Information
UniProt Annotations
Entry Information
Gene Name
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Biophysicochemical Properties | Kinetic parameters: KM=1.8 uM for CDP-ethanolamine ; Vmax=76.3 pmol/min/mg enzyme with CDP-ethanolamine as substrate ; |
Catalytic Activity | CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine |
Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; |
Function | Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway. |
Pathway | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. |
Sequence Caution | Sequence=BAB21815.1; Type=Erroneous termination; Positions=387; Note=Translated as Sec.; Evidence= ; |
Similarity | Belongs to the CDP-alcohol phosphatidyltransferase class-I family |
Subcellular Location | Membrane ; Multi-pass membrane protein |
Tissue Specificity | Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe |
Identical and Related Proteins
Unique RefSeq proteins for LMP012361 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
50083289 | RefSeq | NP_277040 | 397 | ethanolaminephosphotransferase 1 |
Identical Sequences to LMP012361 proteins
Reference | Database | Accession | Length | Protein Name |
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Related Sequences to LMP012361 proteins
Reference | Database | Accession | Length | Protein Name |
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