Gene/Proteome Database (LMPD)

LMPD ID
LMP012365
Gene ID
129642
Species
Homo sapiens (Human)
Gene Name
membrane bound O-acyltransferase domain containing 2
Gene Symbol
MBOAT2
Synonyms
OACT2; LPCAT4;
Chromosome
2
Map Location
2p25.1
EC Number
2.3.1.-

Proteins

lysophospholipid acyltransferase 2
Refseq ID NP_620154
Protein GI 40548387
UniProt ID Q6ZWT7
mRNA ID NM_138799
Length 520
MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

Gene Information

Entrez Gene ID
129642
Gene Name
membrane bound O-acyltransferase domain containing 2
Gene Symbol
MBOAT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003841 IEA:UniProtKB-EC F 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
ko00561 Glycerolipid metabolism
hsa00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways
M00089 Triacylglycerol biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5667 CDP-diacylglycerol biosynthesis I
PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic)
TRIGLSYN-PWY triacylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120829 Acyl chain remodelling of PC
REACT_121369 Acyl chain remodelling of PE
REACT_121401 Glycerophospholipid biosynthesis
REACT_111217 Metabolism
REACT_22258 Metabolism of lipids and lipoproteins
REACT_120870 Phospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT

UniProt Annotations

Entry Information

Gene Name
membrane bound O-acyltransferase domain containing 2
UniProt ID
Q6ZWT7
Species
Human

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Partially inhibited by thimerosal.
Function Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle
Pathway Lipid metabolism; phospholipid metabolism.
Sequence Caution Sequence=BAC11204.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the membrane-bound acyltransferase family
Subcellular Location Membrane ; Multi-pass membrane protein
Tissue Specificity Expressed in neutrophils

Identical and Related Proteins

Unique RefSeq proteins for LMP012365 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40548387 RefSeq NP_620154 520 lysophospholipid acyltransferase 2

Identical Sequences to LMP012365 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012365 proteins

Reference Database Accession Length Protein Name