LIPID MAPS

LMPD ID

LMP012366

Gene ID

154141

Species

Homo sapiens (Human)

Gene Name

membrane bound O-acyltransferase domain containing 1

Gene Symbol

MBOAT1

Synonyms

1; LPLAT; LPSAT; OACT1; LPEAT1; LPLAT 1; dJ434O11.1;

Chromosome

6

Map Location

6p22.3

EC Number

2.3.1.-

Summary

This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

Orthologs

View orthologs and multiple alignments for MBOAT1

lysophospholipid acyltransferase 1
Refseq ID	NP_001073949
Protein GI	122937404
UniProt ID	Q6ZNC8
mRNA ID	NM_001080480
Length	495
MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTGAVIHKLGITLVSLLLFLTLTKTFPVTCLVDDWFVHKASFPARLCYLYVVMQASKPKYYFAWTLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENWNIQTATWLKCVCYQRVPWYPTVLTFILSALWHGVYPGYYFTFLTGILVTLAARAVRNNYRHYFLSSRALKAVYDAGTWAVTQLAVSYTVAPFVMLAVEPTISLYKSMYFYLHIISLLIILFLPMKPQAHTQRRPQTLNSINKRKTD

Entrez Gene ID

154141

Gene Name

membrane bound O-acyltransferase domain containing 1

Gene Symbol

MBOAT1

Species

Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016747	IEA:UniProtKB-EC	F	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046474	TAS:Reactome	P	glycerophospholipid biosynthetic process
GO:0036152	TAS:Reactome	P	phosphatidylethanolamine acyl-chain remodeling
GO:0036150	TAS:Reactome	P	phosphatidylserine acyl-chain remodeling
GO:0006644	TAS:Reactome	P	phospholipid metabolic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa00561	Glycerolipid metabolism
ko00561	Glycerolipid metabolism
hsa00564	Glycerophospholipid metabolism
ko00564	Glycerophospholipid metabolism
hsa01100	Metabolic pathways
M00089	Triacylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_121369	Acyl chain remodelling of PE
REACT_121384	Acyl chain remodelling of PS
REACT_121401	Glycerophospholipid biosynthesis
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_120870	Phospholipid metabolism

InterPro Annotations

Accession	Description
IPR004299	Membrane bound O-acyl transferase, MBOAT

Entry Information

Gene Name

membrane bound O-acyltransferase domain containing 1

UniProt ID

Q6ZNC8

Species

Human

Comments

Comment Type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZNC8-1; Sequence=Displayed; Name=2; IsoId=Q6ZNC8-2; Sequence=VSP_036729; Name=3; IsoId=Q6ZNC8-3; Sequence=VSP_036730, VSP_036731;
Catalytic Activity	Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Enzyme Regulation	Partially inhibited by thimerosal.
Function	Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle
Pathway	Lipid metabolism; phospholipid metabolism.
Similarity	Belongs to the membrane-bound acyltransferase family
Subcellular Location	Membrane ; Multi-pass membrane protein
Tissue Specificity	Expressed in neutrophils