Gene/Proteome Database (LMPD)
LMPD ID
LMP012374
Gene ID
Species
Homo sapiens (Human)
Gene Name
alkylglycerol monooxygenase
Gene Symbol
Synonyms
TMEM195;
Chromosome
7
Map Location
7p21.2
Summary
The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]
Orthologs
Proteins
| alkylglycerol monooxygenase | |
|---|---|
| Refseq ID | NP_001004320 |
| Protein GI | 51972212 |
| UniProt ID | X5D773 |
| mRNA ID | NM_001004320 |
| Length | 445 |
| MKNPEAQQDVSVSQGFRMLFYTMKPSETSFQTLEEVPDYVKKATPFFISLMLLELVVSWILKGKPPGRLDDALTSISAGVLSRLPSLFFRSIELTSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVINNLGPLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFEPIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSSSSSQLLKIYTVVQFALMLAFYEETFADTAALSQVTLLLRVCFIILTLTSIGFLLDQRPKAAIMETLRCLMFLMLYRFGHLKPLVPSLSSAFEIVFSICIAFWGVRSMKQLTSHPWK | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0004497 | IEA:UniProtKB-KW | F | monooxygenase activity |
| GO:0006633 | IEA:InterPro | P | fatty acid biosynthetic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006694 | Fatty_acid_hydroxylase |
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP012374 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 51972212 | RefSeq | NP_001004320 | 445 | alkylglycerol monooxygenase |
Identical Sequences to LMP012374 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP012374 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|