Gene/Proteome Database (LMPD)

LMPD ID
LMP012389
Gene ID
24172
Species
Rattus norvegicus (Rat)
Gene Name
alcohol dehydrogenase 1 (class I)
Gene Symbol
Adh1
Synonyms
Adh; Adh1a; Adh1c;
Alternate Names
alcohol dehydrogenase 1; alcohol dehydrogenase A subunit; alcohol dehydrogenase 1, complex; alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1C (class I), gamma polypeptide;
Chromosome
2
Map Location
2q44
EC Number
1.1.1.1
Summary
alpha subunit of class I alcohol dehydrogenase; metabolizes a wide variety of substrates including ethanol, hydroxysteroids and lipid peroxidation products [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Adh1

Proteins

alcohol dehydrogenase 1
Refseq ID NP_062159
Protein GI 158081755
UniProt ID P06757
mRNA ID NM_019286
Length 376
MSTAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPLPAVLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLVADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF

Gene Information

Entrez Gene ID
24172
Gene Name
alcohol dehydrogenase 1 (class I)
Gene Symbol
Adh1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0051287 IDA:RGD F NAD binding
GO:0004022 IDA:RGD F alcohol dehydrogenase (NAD) activity
GO:0008144 IPI:RGD F drug binding
GO:0035276 IDA:RGD F ethanol binding
GO:0004745 IDA:RGD F retinol dehydrogenase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0046186 IDA:RGD P acetaldehyde biosynthetic process
GO:0006069 IDA:RGD P ethanol oxidation
GO:0031100 IEP:RGD P organ regeneration
GO:0032570 IEP:RGD P response to progesterone

KEGG Pathway Links

KEGG Pathway ID Description
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko00830 Retinol metabolism
rno00830 Retinol metabolism
ko00350 Tyrosine metabolism
rno00350 Tyrosine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 1 (class I)
Protein Entry
ADH1_RAT
UniProt ID
P06757
Species
Rat

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily
Subcellular Location Cytoplasm.
Subunit Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.

Identical and Related Proteins

Unique RefSeq proteins for LMP012389 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158081755 RefSeq NP_062159 376 alcohol dehydrogenase 1

Identical Sequences to LMP012389 proteins

Reference Database Accession Length Protein Name
GI:158081755 GenBank AAA85462.1 376 alcohol dehydrogenase [Rattus norvegicus]
GI:158081755 GenBank AAH62403.1 376 Alcohol dehydrogenase 1 (class I) [Rattus norvegicus]
GI:158081755 SwissProt P06757.3 376 RecName: Full=Alcohol dehydrogenase 1; AltName: Full=Alcohol dehydrogenase A subunit [Rattus norvegicus]

Related Sequences to LMP012389 proteins

Reference Database Accession Length Protein Name
GI:158081755 GenBank AAA85462.1 376 alcohol dehydrogenase [Rattus norvegicus]
GI:158081755 GenBank AAH62403.1 376 Alcohol dehydrogenase 1 (class I) [Rattus norvegicus]
GI:158081755 SwissProt P06757.3 376 RecName: Full=Alcohol dehydrogenase 1; AltName: Full=Alcohol dehydrogenase A subunit [Rattus norvegicus]