Gene/Proteome Database (LMPD)

LMPD ID
LMP012390
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 1 family, member A1
Gene Symbol
Synonyms
Ahd2; Aldh1; Aldh2;
Alternate Names
retinal dehydrogenase 1; ALHDII; ralDH1; ALDH-E1; RALDH 1; aldehyde dehydrogenase 2; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1;
Chromosome
1
Map Location
1q51
EC Number
1.2.1.36
Summary
ubiquitous enzyme located in virtually all mammalian tissues; catalyzes oxidation of aldehyde substrates to carboxylic acids; detoxifies ethanol-derived acetaldehyde [RGD, Feb 2006]
Orthologs

Proteins

retinal dehydrogenase 1
Refseq ID NP_071852
Protein GI 14192935
UniProt ID P51647
mRNA ID NM_022407
Length 501
MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS

Gene Information

Entrez Gene ID
Gene Name
aldehyde dehydrogenase 1 family, member A1
Gene Symbol
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005634 IDA:RGD C nucleus
GO:0004028 TAS:RGD F 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 IDA:RGD F aldehyde dehydrogenase (NAD) activity
GO:0018479 IDA:RGD F benzaldehyde dehydrogenase (NAD+) activity
GO:0042802 IDA:RGD F identical protein binding
GO:0001758 IDA:RGD F retinal dehydrogenase activity
GO:0042904 IEA:Ensembl P 9-cis-retinoic acid biosynthetic process
GO:0042905 IDA:RGD P 9-cis-retinoic acid metabolic process
GO:0060206 IEP:RGD P estrous cycle phase
GO:0001822 IEP:RGD P kidney development
GO:0001889 IEP:RGD P liver development
GO:0007494 IEP:RGD P midgut development
GO:0002072 IEA:Ensembl P optic cup morphogenesis involved in camera-type eye development
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0051289 IDA:RGD P protein homotetramerization
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0045471 IDA:RGD P response to ethanol
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0006979 IMP:RGD P response to oxidative stress
GO:0032526 IEP:RGD P response to retinoic acid
GO:0002138 IMP:RGD P retinoic acid biosynthetic process
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953325 Ethanol oxidation
5953250 Metabolism
5953326 Phase 1 - Functionalization of compounds

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 1 family, member A1
Protein Entry
AL1A1_RAT
UniProt ID
Species
Rat

Comments

Comment Type Description
Catalytic Activity Retinal + NAD(+) + H(2)O = retinoate + NADH.
Enzyme Regulation Inhibited by chloral hydrate.
Function Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal.
Pathway Cofactor metabolism; retinol metabolism.
Ptm The N-terminus is blocked.
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Cytoplasm.
Subunit Homotetramer
Tissue Specificity Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012390 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14192935 RefSeq NP_071852 501 retinal dehydrogenase 1

Identical Sequences to LMP012390 proteins

Reference Database Accession Length Protein Name
GI:14192935 GenBank AAH61526.1 501 Aldehyde dehydrogenase 1 family, member A1 [Rattus norvegicus]
GI:14192935 GenBank EDM12994.1 501 rCG47846 [Rattus norvegicus]
GI:14192935 GenBank AEK13597.1 501 Sequence 9 from patent US 7972785
GI:14192935 SwissProt P51647.3 501 RecName: Full=Retinal dehydrogenase 1; Short=RALDH 1; Short=RalDH1; AltName: Full=ALDH-E1; AltName: Full=ALHDII; AltName: Full=Aldehyde dehydrogenase family 1 member A1; AltName: Full=Aldehyde dehydrogenase, cytosolic [Rattus norvegicus]

Related Sequences to LMP012390 proteins

Reference Database Accession Length Protein Name
GI:14192935 GenBank AAC53304.1 501 aldehyde dehydrogenase [Rattus norvegicus]
GI:14192935 GenBank AAC53305.1 501 aldehyde dehydrogenase [Rattus norvegicus]
GI:14192935 GenBank AAC53306.1 501 aldehyde dehydrogenase [Rattus norvegicus]