Gene/Proteome Database (LMPD)
LMPD ID
LMP012392
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein C-III
Gene Symbol
Synonyms
ApoC-III; apo-CIII;
Alternate Names
apolipoprotein C-III; apolipoprotein C3; apolipoprotein C-3;
Chromosome
8
Map Location
8q23-q24
Summary
very low density lipoprotein (VLDL) that comprises a major component of the lipid transport system; increased levels induce hypertriglyceridemia [RGD, Feb 2006]
Orthologs
Proteins
apolipoprotein C-III precursor | |
---|---|
Refseq ID | NP_036633 |
Protein GI | 402534546 |
mRNA ID | NM_012501 |
Length | 100 |
MQPRMLLIVALVALLASARADEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVARGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP | |
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2138 peptide sequence: MQPRMLLIVALVALLASARA mat_peptide: 21..100 product: apolipoprotein C-III calculated_mol_wt: 8910 peptide sequence: DEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVARGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2138 peptide sequence: MQPRMLLIVALVALLASARA mat_peptide: 21..100 product: apolipoprotein C-III calculated_mol_wt: 8910 peptide sequence: DEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVARGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP |
apolipoprotein C-III precursor | |
---|---|
Refseq ID | NP_001257982 |
Protein GI | 402534548 |
mRNA ID | NM_001271053 |
Length | 100 |
Protein sequence is identical to GI:402534546 (mRNA isoform) | |
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2138 peptide sequence: MQPRMLLIVALVALLASARA mat_peptide: 21..100 product: apolipoprotein C-III calculated_mol_wt: 8910 peptide sequence: DEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVARGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
GO:0005615 | IDA:RGD | C | extracellular space |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0034363 | IEA:Ensembl | C | intermediate-density lipoprotein particle |
GO:0034366 | IEA:Ensembl | C | spherical high-density lipoprotein particle |
GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
GO:0055102 | IEA:Ensembl | F | lipase inhibitor activity |
GO:0005319 | TAS:RGD | F | lipid transporter activity |
GO:0005543 | IEA:Ensembl | F | phospholipid binding |
GO:0007186 | IEA:Ensembl | P | G-protein coupled receptor signaling pathway |
GO:0071333 | IDA:RGD | P | cellular response to glucose stimulus |
GO:0033344 | IEA:Ensembl | P | cholesterol efflux |
GO:0042632 | IEA:Ensembl | P | cholesterol homeostasis |
GO:0008203 | IEA:Ensembl | P | cholesterol metabolic process |
GO:0034382 | IEA:Ensembl | P | chylomicron remnant clearance |
GO:0034375 | IEA:Ensembl | P | high-density lipoprotein particle remodeling |
GO:0006954 | IEP:RGD | P | inflammatory response |
GO:0006869 | TAS:RGD | P | lipid transport |
GO:0042157 | IEA:InterPro | P | lipoprotein metabolic process |
GO:0042953 | IDA:RGD | P | lipoprotein transport |
GO:0060621 | IEA:Ensembl | P | negative regulation of cholesterol import |
GO:0045717 | IEA:Ensembl | P | negative regulation of fatty acid biosynthetic process |
GO:0010987 | IEA:Ensembl | P | negative regulation of high-density lipoprotein particle clearance |
GO:0051005 | IEA:Ensembl | P | negative regulation of lipoprotein lipase activity |
GO:0010989 | IEA:Ensembl | P | negative regulation of low-density lipoprotein particle clearance |
GO:0048261 | IEA:Ensembl | P | negative regulation of receptor-mediated endocytosis |
GO:0010897 | IEA:Ensembl | P | negative regulation of triglyceride catabolic process |
GO:0010916 | IEA:Ensembl | P | negative regulation of very-low-density lipoprotein particle clearance |
GO:0033700 | IEA:Ensembl | P | phospholipid efflux |
GO:0032489 | IEA:Ensembl | P | regulation of Cdc42 protein signal transduction |
GO:0042493 | IEP:RGD | P | response to drug |
GO:0007584 | IEP:RGD | P | response to nutrient |
GO:0043434 | IDA:RGD | P | response to peptide hormone |
GO:0019433 | IEA:Ensembl | P | triglyceride catabolic process |
GO:0070328 | IEA:Ensembl | P | triglyceride homeostasis |
GO:0006642 | IEA:Ensembl | P | triglyceride mobilization |
KEGG Pathway Links
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
5953879 | Chylomicron-mediated lipid transport |
5953253 | Disease |
5953382 | Diseases associated with visual transduction |
5954088 | HDL-mediated lipid transport |
5953754 | Lipid digestion, mobilization, and transport |
5953836 | Lipoprotein metabolism |
5953250 | Metabolism |
5953289 | Metabolism of lipids and lipoproteins |
5954392 | Retinoid metabolism and transport |
5953381 | Signal Transduction |
5953380 | Visual phototransduction |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR008403 | Apolipoprotein CIII |
UniProt Annotations
Entry Information
Gene Name
apolipoprotein C-III
Species
Rat
Comments
Comment Type | Description |
---|---|
Function | Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. {ECO:0000250|UniProtKB:P02656}. |
Ptm | The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal- GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-96 with a core 1 or possibly core 8 glycan. {ECO:0000250|UniProtKB:P02656}. |
Similarity | Belongs to the apolipoprotein C3 family. {ECO:0000305}. |
Subcellular Location | Secreted {ECO:0000250|UniProtKB:P02656}. |
Tissue Specificity | Synthesized predominantly in liver and to a lesser degree in intestine. {ECO:0000269|PubMed:3020028}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012392 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
402534546 | RefSeq | NP_036633 | 100 | apolipoprotein C-III precursor |
Identical Sequences to LMP012392 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:402534548 | GenBank | EDL95395.1 | 100 | apolipoprotein C-III, isoform CRA_a [Rattus norvegicus] |
GI:402534546 | GenBank | EDL95395.1 | 100 | apolipoprotein C-III, isoform CRA_a [Rattus norvegicus] |
GI:402534548 | RefSeq | NP_036633.2 | 100 | apolipoprotein C-III precursor [Rattus norvegicus] |
GI:402534546 | RefSeq | NP_001257982.1 | 100 | apolipoprotein C-III precursor [Rattus norvegicus] |
Related Sequences to LMP012392 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:402534548 | GenBank | AAA40746.1 | 101 | preapolipoprotein C-III [Rattus norvegicus] |
GI:402534548 | GenBank | EDL95395.1 | 100 | apolipoprotein C-III, isoform CRA_a [Rattus norvegicus] |
GI:402534546 | GenBank | EDL95395.1 | 100 | apolipoprotein C-III, isoform CRA_a [Rattus norvegicus] |
GI:402534548 | RefSeq | NP_036633.2 | 100 | apolipoprotein C-III precursor [Rattus norvegicus] |
GI:402534546 | RefSeq | NP_001257982.1 | 100 | apolipoprotein C-III precursor [Rattus norvegicus] |
GI:402534546 | SwissProt | P06759.2 | 101 | RecName: Full=Apolipoprotein C-III; Short=Apo-CIII; Short=ApoC-III; AltName: Full=Apolipoprotein C3; Flags: Precursor [Rattus norvegicus] |
GI:402534548 | SwissProt | P06759.2 | 101 | RecName: Full=Apolipoprotein C-III; Short=Apo-CIII; Short=ApoC-III; AltName: Full=Apolipoprotein C3; Flags: Precursor [Rattus norvegicus] |