Gene/Proteome Database (LMPD)

LMPD ID
LMP012395
Gene ID
24254
Species
Rattus norvegicus (Rat)
Gene Name
carboxyl ester lipase
Gene Symbol
Cel
Synonyms
Bal; Bssl;
Alternate Names
bile salt-activated lipase; sterol esterase; cholesterol esterase; bile salt-stimulated lipase; pancreatic lysophospholipase;
Chromosome
3
Map Location
3p12
Summary
member of the serine esterase gene family; may have a short half-life in vivo [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cel

Proteins

bile salt-activated lipase precursor
Refseq ID NP_058693
Protein GI 302058302
UniProt ID G3V7G2
mRNA ID NM_016997
Length 612
MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQVVPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPVAIGF
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2056 peptide sequence: MGRLEVLFLGLTCCLAAACA mat_peptide: 21..612 product: Bile salt-activated lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P07882.2) calculated_mol_wt: 65103 peptide sequence: AKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQVVPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPVAIGF

Gene Information

Entrez Gene ID
24254
Gene Name
carboxyl ester lipase
Gene Symbol
Cel
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0046514 IEA:Ensembl P ceramide catabolic process
GO:0006707 IEA:Ensembl P cholesterol catabolic process
GO:0030157 IEA:Ensembl P pancreatic juice secretion

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953935 Digestion of dietary lipid
5953754 Lipid digestion, mobilization, and transport
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002018 Carboxylesterase, type B
IPR019826 Carboxylesterase type B, active site
IPR019819 Carboxylesterase type B, conserved site

UniProt Annotations

Entry Information

Gene Name
carboxyl ester lipase
Protein Entry
G3V7G2_RAT
UniProt ID
G3V7G2
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012395 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
302058302 RefSeq NP_058693 612 bile salt-activated lipase precursor

Identical Sequences to LMP012395 proteins

Reference Database Accession Length Protein Name
GI:302058302 GenBank EDL93408.1 612 carboxyl ester lipase, isoform CRA_b [Rattus norvegicus]

Related Sequences to LMP012395 proteins

Reference Database Accession Length Protein Name
GI:302058302 GenBank AAB46376.1 612 cholesterol esterase [Rattus norvegicus]
GI:302058302 GenBank EDL93408.1 612 carboxyl ester lipase, isoform CRA_b [Rattus norvegicus]
GI:302058302 SwissProt P07882.2 612 RecName: Full=Bile salt-activated lipase; Short=BAL; AltName: Full=Bile salt-stimulated lipase; Short=BSSL; AltName: Full=Carboxyl ester lipase; AltName: Full=Cholesterol esterase; AltName: Full=Pancreatic lysophospholipase; AltName: Full=Sterol esterase; Flags: Precursor [Rattus norvegicus]