Gene/Proteome Database (LMPD)

LMPD ID
LMP012400
Gene ID
24314
Species
Rattus norvegicus (Rat)
Gene Name
NAD(P)H dehydrogenase, quinone 1
Gene Symbol
Nqo1
Synonyms
Dia4;
Alternate Names
NAD(P)H dehydrogenase [quinone] 1; DTD; QR1; azoreductase; DT-diaphorase; menadione reductase; quinone reductase 1; Diaphorase (NADH/NADPH); phylloquinone reductase; NAD(P)H:menadione oxidoreductase; NAD(P)H:quinone oxidoreductase 1;
Chromosome
19
Map Location
19q12
EC Number
1.6.5.2
Summary
enzyme that acts as an antioxidant; involved in increasing neuronal damage after injury [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nqo1

Proteins

NAD(P)H dehydrogenase [quinone] 1
Refseq ID NP_058696
Protein GI 27501444
UniProt ID P05982
mRNA ID NM_017000
Length 274
MAVRRALIVLAHAERTSFNYAMKEAAVEALKKKGWEVVESDLYAMNFNPLISRNDITGEPKDSENFQYPVESSLAYKEGRLSPDIVAEQKKLEAADLVIFQFPLYWFGVPAILKGWFERVLVAGFAYTYATMYDKGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARVQVLEGWKKRLETVWEESPLYFAPSSLFDLNFQAGFLLKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK

Gene Information

Entrez Gene ID
24314
Gene Name
NAD(P)H dehydrogenase, quinone 1
Gene Symbol
Nqo1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043025 IDA:RGD C neuronal cell body
GO:0003955 IDA:RGD F NAD(P)H dehydrogenase (quinone) activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0004784 IMP:RGD F superoxide dismutase activity
GO:0007568 IEP:RGD P aging
GO:0043086 IEA:Ensembl P negative regulation of catalytic activity
GO:0043525 IMP:RGD P positive regulation of neuron apoptotic process
GO:0019430 IMP:GOC P removal of superoxide radicals
GO:0032355 IEP:RGD P response to estradiol
GO:0045471 IEP:RGD P response to ethanol
GO:0007584 IEP:RGD P response to nutrient
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0006979 IEP:RGD P response to oxidative stress
GO:0006801 IMP:RGD P superoxide metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00130 Ubiquinone and other terpenoid-quinone biosynthesis
rno00130 Ubiquinone and other terpenoid-quinone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives
5954100 Regulation of ornithine decarboxylase (ODC)

Domain Information

InterPro Annotations

Accession Description
IPR003680 Flavodoxin-like fold
IPR029039 Flavoprotein-like

UniProt Annotations

Entry Information

Gene Name
NAD(P)H dehydrogenase, quinone 1
Protein Entry
NQO1_RAT
UniProt ID
P05982
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=85 uM for NADH ; KM=39 uM for NADPH ; Note=kcat is 0.075 min(-1) NADH with as substrate. kcat is 0.074 min(-1) with NADPH as substrate ;
Catalytic Activity NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO:0000269|PubMed:1703398, ECO:0000269|PubMed:7862630}.
Caution PubMed:2480957 sequence seems incorrectly to be attributed to a mouse sequence while it really seems to correspond to the rat sequence
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:1703398, ECO:0000269|PubMed:7862630}.
Induction By polycyclic hydrocarbons (Governed by the aromatic hydrocarbon-responsive (AH) locus).
Miscellaneous Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
Miscellaneous This protein is inhibited by dicoumarol.
Sequence Caution Sequence=AAA41988.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the NAD(P)H dehydrogenase (quinone) family
Subcellular Location Cytoplasm .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012400 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27501444 RefSeq NP_058696 274 NAD(P)H dehydrogenase [quinone] 1

Identical Sequences to LMP012400 proteins

Reference Database Accession Length Protein Name
GI:27501444 GenBank AAA41989.1 274 NAD(P)H:quinone reductase [Rattus norvegicus]
GI:27501444 GenBank AAH83542.1 274 NAD(P)H dehydrogenase, quinone 1 [Rattus norvegicus]
GI:27501444 GenBank EDL92478.1 274 NAD(P)H dehydrogenase, quinone 1 [Rattus norvegicus]
GI:27501444 PIR - 274 NAD(P)H2 dehydrogenase (quinone) (EC 1.6.99.2) 1 [similarity] - mouse [Mus musculus]

Related Sequences to LMP012400 proteins

Reference Database Accession Length Protein Name
GI:27501444 GenBank AAA39829.1 274 NAD(P)H oxidoreductase (EC 1.6.99.2) [Mus musculus]
GI:27501444 GenBank AAA41715.1 274 NAD(P)H:menadione oxidoreductase (EC 1.6.99.2) [Rattus norvegicus]
GI:27501444 SwissProt P05982.4 274 RecName: Full=NAD(P)H dehydrogenase [quinone] 1; AltName: Full=Azoreductase; AltName: Full=DT-diaphorase; Short=DTD; AltName: Full=Menadione reductase; AltName: Full=NAD(P)H:quinone oxidoreductase 1; AltName: Full=Phylloquinone reductase; AltName: Full=Quinone reductase 1; Short=QR1 [Rattus norvegicus]