Gene/Proteome Database (LMPD)

LMPD ID
LMP012406
Gene ID
24413
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 3, group C, member 1
Gene Symbol
Nr3c1
Synonyms
GR; Gcr; Grl;
Alternate Names
glucocorticoid receptor;
Chromosome
18
Map Location
18p12
Summary
glucocorticoid receptor that binds and activates hormone-dependent transcriptional enhancers [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr3c1

Proteins

glucocorticoid receptor
Refseq ID NP_036708
Protein GI 158303300
UniProt ID P06536
mRNA ID NM_012576
Length 794
MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKTHSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPGKDTNESPWRSDLLIDENLLSPLAGEDDPFLLEGDTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRPDVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQCKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

Gene Information

Entrez Gene ID
24413
Gene Name
nuclear receptor subfamily 3, group C, member 1
Gene Symbol
Nr3c1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0043197 IDA:RGD C dendritic spine
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0043005 IDA:RGD C neuron projection
GO:0005634 IDA:RGD C nucleus
GO:0014069 IDA:RGD C postsynaptic density
GO:0043234 IDA:RGD C protein complex
GO:0003682 IDA:RGD F chromatin binding
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0004883 IEA:InterPro F glucocorticoid receptor activity
GO:0031072 IDA:RGD F heat shock protein binding
GO:0042562 IPI:RGD F hormone binding
GO:0030544 IDA:RGD F Hsp70 protein binding
GO:0051879 IDA:RGD F Hsp90 protein binding
GO:0032403 IDA:UniProtKB F protein complex binding
GO:0046983 TAS:RGD F protein dimerization activity
GO:0046982 IDA:RGD F protein heterodimerization activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0030971 IPI:RGD F receptor tyrosine kinase binding
GO:0001012 IDA:RGD F RNA polymerase II regulatory region DNA binding
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IMP:RGD F sequence-specific DNA binding transcription factor activity
GO:0005496 IPI:RGD F steroid binding
GO:0003713 IDA:RGD F transcription coactivator activity
GO:0008134 IPI:RGD F transcription factor binding
GO:0008270 TAS:RGD F zinc ion binding
GO:0007568 IEP:RGD P aging
GO:0008209 IEP:RGD P androgen metabolic process
GO:0007420 IEP:RGD P brain development
GO:0071549 IMP:RGD P cellular response to dexamethasone stimulus
GO:0071286 IEP:RGD P cellular response to magnesium ion
GO:0048096 IMP:UniProtKB P chromatin-mediated maintenance of transcription
GO:0006338 IMP:UniProtKB P chromatin remodeling
GO:0007623 IEP:RGD P circadian rhythm
GO:0030324 IEP:RGD P lung development
GO:0014889 IEP:RGD P muscle atrophy
GO:0031914 IMP:RGD P negative regulation of synaptic plasticity
GO:0043116 IMP:RGD P negative regulation of vascular permeability
GO:0061051 IMP:RGD P positive regulation of cell growth involved in cardiac muscle cell development
GO:0060999 IMP:RGD P positive regulation of dendritic spine development
GO:2000324 IDA:RGD P positive regulation of glucocorticoid receptor signaling pathway
GO:0014049 IMP:RGD P positive regulation of glutamate secretion
GO:0045944 IDA:RGD P positive regulation of transcription from RNA polymerase II promoter
GO:0042127 IDA:RGD P regulation of cell proliferation
GO:0010906 IMP:RGD P regulation of glucose metabolic process
GO:0014823 IEP:RGD P response to activity
GO:0046685 IDA:RGD P response to arsenic-containing substance
GO:0051592 IEP:RGD P response to calcium ion
GO:0051412 IEP:RGD P response to corticosterone
GO:0071548 IEP:RGD P response to dexamethasone
GO:0051602 IEP:RGD P response to electrical stimulus
GO:0014854 IEP:RGD P response to inactivity
GO:0032868 IEP:RGD P response to insulin
GO:0046689 IEP:RGD P response to mercury ion
GO:0009314 IEP:RGD P response to radiation
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

Domain Information

InterPro Annotations

Accession Description
IPR001409 Glucocorticoid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 3, group C, member 1
Protein Entry
GCR_RAT
UniProt ID
P06536
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative initiation; Named isoforms=2; Name=A; IsoId=P06536-1; Sequence=Displayed; Name=B; IsoId=P06536-2; Sequence=VSP_018969;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression (By similarity)
Interaction Q62667:Mvp; NbExp=2; IntAct=EBI-1187143, EBI-918333; Q15788:NCOA1 (xeno); NbExp=2; IntAct=EBI-1187143, EBI-455189; P51532:SMARCA4 (xeno); NbExp=3; IntAct=EBI-1187143, EBI-302489; Q96GM5:SMARCD1 (xeno); NbExp=2; IntAct=EBI-1187143, EBI-358489;
Ptm Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity
Ptm Increased proteasome-mediated degradation in response to glucocorticoids.
Ptm Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity)
Ptm Sumoylations at Lys-297 and Lys-313 negatively regulate its transcriptional activity. Sumoylation at Lys-721 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylations at Lys-297 and Lys-313 are dispensable whereas sumoylation at Lys-721 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWWD3-dependent manner
Ptm Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Cytoplasm . Mitochondrion {ECO:0000250}. Nucleus . Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding
Subunit Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand- dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. {ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:10866662, ECO:0000269|PubMed:12118039, ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:9111344}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012406 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158303300 RefSeq NP_036708 794 glucocorticoid receptor

Identical Sequences to LMP012406 proteins

Reference Database Accession Length Protein Name
GI:158303300 GenBank EDL76462.1 794 nuclear receptor subfamily 3, group C, member 1 [Rattus norvegicus]
GI:158303300 RefSeq XP_008770287.1 794 PREDICTED: glucocorticoid receptor isoform X1 [Rattus norvegicus]
GI:158303300 RefSeq XP_008770288.1 794 PREDICTED: glucocorticoid receptor isoform X1 [Rattus norvegicus]

Related Sequences to LMP012406 proteins

Reference Database Accession Length Protein Name
GI:158303300 GenBank EDL76462.1 794 nuclear receptor subfamily 3, group C, member 1 [Rattus norvegicus]
GI:158303300 RefSeq XP_008770287.1 794 PREDICTED: glucocorticoid receptor isoform X1 [Rattus norvegicus]
GI:158303300 RefSeq XP_008770288.1 794 PREDICTED: glucocorticoid receptor isoform X1 [Rattus norvegicus]