Gene/Proteome Database (LMPD)

LMPD ID
LMP012407
Gene ID
24434
Species
Rattus norvegicus (Rat)
Gene Name
glucuronidase, beta
Gene Symbol
Gusb
Synonyms
Gus-s; Ac2-223;
Alternate Names
beta-glucuronidase;
Chromosome
12
Map Location
12q13
EC Number
3.2.1.31
Summary
catalyzes the conversion of a beta-D-glucuronoside and H2O to an alcohol and D-glucuronate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gusb

Proteins

beta-glucuronidase precursor
Refseq ID NP_058711
Protein GI 158303310
UniProt ID P06760
mRNA ID NM_017015
Length 648
MSPRRSVCWFVLGQLLCSCALALQGGMLFPKETPSRELKVLDGLWSFRADYSNNRLQGFEKQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYEREAVLPQRWTQDTDRRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSGPLTTFRVTIAINNTLTPYTLPPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVVLYTTPTTYIDDITVTTDVDRDVGLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNEGQLKVPRAHLWWPYLMHEHPAYLYSLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGRGFDWPLLIKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNVSLRHHLEVMDELVRRDKNHPAVVMWSVANEPVSSLKPAGYYFKTLIAHTKALDPTRPVTFVSNTRYDADMGAPYVDVICVNSYLSWYHDYGHLEVIQLQLTSQFENWYKMYQKPIIQSEYGADAVSGLHEDPPRMFSEEYQTALLENYHLILDEKRKEYVIGELIWNFADFMTNQSPLRVTGNKKGIFTRQRNPKMAAFILRERYWRIANETRGYGSVPRTQCMGSRPFTF
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2441 peptide sequence: MSPRRSVCWFVLGQLLCSCALA mat_peptide: 23..648 product: Beta-glucuronidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P06760.1) calculated_mol_wt: 72385 peptide sequence: LQGGMLFPKETPSRELKVLDGLWSFRADYSNNRLQGFEKQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYEREAVLPQRWTQDTDRRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSGPLTTFRVTIAINNTLTPYTLPPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVVLYTTPTTYIDDITVTTDVDRDVGLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNEGQLKVPRAHLWWPYLMHEHPAYLYSLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGRGFDWPLLIKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNVSLRHHLEVMDELVRRDKNHPAVVMWSVANEPVSSLKPAGYYFKTLIAHTKALDPTRPVTFVSNTRYDADMGAPYVDVICVNSYLSWYHDYGHLEVIQLQLTSQFENWYKMYQKPIIQSEYGADAVSGLHEDPPRMFSEEYQTALLENYHLILDEKRKEYVIGELIWNFADFMTNQSPLRVTGNKKGIFTRQRNPKMAAFILRERYWRIANETRGYGSVPRTQCMGSRPFTF

Gene Information

Entrez Gene ID
24434
Gene Name
glucuronidase, beta
Gene Symbol
Gusb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IDA:RGD C lysosome
GO:0004566 IDA:RGD F beta-glucuronidase activity
GO:0030246 IDA:RGD F carbohydrate binding
GO:0005975 IEA:InterPro P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate
M00077 Chondroitin sulfate degradation
M00076 Dermatan sulfate degradation
ko00983 Drug metabolism - other enzymes
rno00983 Drug metabolism - other enzymes
M00014 Glucuronate pathway (uronate pathway)
ko00531 Glycosaminoglycan degradation
rno00531 Glycosaminoglycan degradation
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways
ko00040 Pentose and glucuronate interconversions
rno00040 Pentose and glucuronate interconversions
ko00860 Porphyrin and chlorophyll metabolism
rno00860 Porphyrin and chlorophyll metabolism
ko00500 Starch and sucrose metabolism
rno00500 Starch and sucrose metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5953252 Glycogen storage diseases
5953861 Glycosaminoglycan metabolism
5954498 HS-GAG degradation
5954347 Heparan sulfate/heparin (HS-GAG) metabolism
5954547 Hyaluronan metabolism
5954548 Hyaluronan uptake and degradation
5953870 MPS I - Hurler syndrome
5953869 MPS II - Hunter syndrome
5953872 MPS IIIA - Sanfilippo syndrome A
5953864 MPS IIIB - Sanfilippo syndrome B
5953867 MPS IIIC - Sanfilippo syndrome C
5953871 MPS IIID - Sanfilippo syndrome D
5953866 MPS IV - Morquio syndrome A
5953873 MPS IV - Morquio syndrome B
5953862 MPS IX - Natowicz syndrome
5953865 MPS VI - Maroteaux-Lamy syndrome
5953868 MPS VII - Sly syndrome
5953250 Metabolism
5953249 Metabolism of carbohydrates
5953863 Mucopolysaccharidoses
5953251 Myoclonic epilepsy of Lafora

Domain Information

InterPro Annotations

Accession Description
IPR008979 Galactose-binding domain-like
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain
IPR006101 Glycoside hydrolase, family 2
IPR006103 Glycoside hydrolase, family 2, TIM barrel
IPR023232 Glycoside hydrolase, family 2, active site
IPR023230 Glycoside hydrolase, family 2, conserved site
IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
IPR006104 Glycosyl hydrolases family 2, sugar binding domain

UniProt Annotations

Entry Information

Gene Name
glucuronidase, beta
Protein Entry
BGLR_RAT
UniProt ID
P06760
Species
Rat

Comments

Comment Type Description
Catalytic Activity A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol.
Enzyme Regulation Inhibited by L-aspartic acid
Function Plays an important role in the degradation of dermatan and keratan sulfates.
Ptm Undergoes a post-transcriptional proteolytic cleavage near its C-terminal end, which reduces its size by approximately 3 kDa. The site of this cleavage has as yet not been determined.
Similarity Belongs to the glycosyl hydrolase 2 family
Subcellular Location Lysosome.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012407 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158303310 RefSeq NP_058711 648 beta-glucuronidase precursor

Identical Sequences to LMP012407 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012407 proteins

Reference Database Accession Length Protein Name
GI:158303310 GenBank AAA41228.1 648 beta-glucuronidase precursor [Rattus norvegicus]
GI:158303310 GenBank ABN17159.1 648 Sequence 14 from patent US 7148407
GI:158303310 SwissProt P06760.1 648 RecName: Full=Beta-glucuronidase; Flags: Precursor [Rattus norvegicus]