Gene/Proteome Database (LMPD)
LMPD ID
LMP012408
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Gene Symbol
Synonyms
Hmgcs1; Mt3h3mg;
Alternate Names
hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 2; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutary-Coenzyme A synthase 2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial);
Chromosome
2
Map Location
2q34
Summary
HMG-CoA cycle enzyme that catalyzes a step in ketone-body biosynthesis [RGD, Feb 2006]
Orthologs
Proteins
| hydroxymethylglutaryl-CoA synthase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_775117 |
| Protein GI | 401461794 |
| UniProt ID | Q68G44 |
| mRNA ID | NM_173094 |
| Length | 508 |
| MQRLLAPARRVLQVKRVMQESSLSPAHLLPAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARRPV | |
| transit_peptide: 1..37 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Probable); propagated from UniProtKB/Swiss-Prot (P22791.1) calculated_mol_wt: 4215 peptide sequence: MQRLLAPARRVLQVKRVMQESSLSPAHLLPAAQQRFS mat_peptide: 38..508 product: Hydroxymethylglutaryl-CoA synthase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P22791.1) calculated_mol_wt: 52689 peptide sequence: TIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARRPV | |
Gene Information
Entrez Gene ID
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005743 | IEA:Ensembl | C | mitochondrial inner membrane |
| GO:0004421 | IEA:InterPro | F | hydroxymethylglutaryl-CoA synthase activity |
| GO:0008299 | IEA:InterPro | P | isoprenoid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00650 | Butanoate metabolism |
| rno00650 | Butanoate metabolism |
| M00095 | C5 isoprenoid biosynthesis, mevalonate pathway |
| rno01100 | Metabolic pathways |
| ko03320 | PPAR signaling pathway |
| rno03320 | PPAR signaling pathway |
| ko00072 | Synthesis and degradation of ketone bodies |
| rno00072 | Synthesis and degradation of ketone bodies |
| ko00900 | Terpenoid backbone biosynthesis |
| rno00900 | Terpenoid backbone biosynthesis |
| ko00280 | Valine, leucine and isoleucine degradation |
| rno00280 | Valine, leucine and isoleucine degradation |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953288 | Fatty acid, triacylglycerol, and ketone body metabolism |
| 5953366 | Ketone body metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5954333 | PPARA activates gene expression |
| 5954222 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| 5953365 | Synthesis of Ketone Bodies |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR010122 | Hydroxymethylglutaryl-CoA synthase, eukaryotic |
| IPR013746 | Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain |
| IPR013528 | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal |
| IPR000590 | Hydroxymethylglutaryl-coenzyme A synthase, active site |
| IPR016039 | Thiolase-like |
| IPR016038 | Thiolase-like, subgroup |
UniProt Annotations
Entry Information
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Protein Entry
Q68G44_RAT
UniProt ID
Species
Rat
Identical and Related Proteins
Unique RefSeq proteins for LMP012408 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 401461794 | RefSeq | NP_775117 | 508 | hydroxymethylglutaryl-CoA synthase, mitochondrial precursor |
Identical Sequences to LMP012408 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:401461794 | GenBank | AAH83543.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) [Rattus norvegicus] |
| GI:401461794 | GenBank | EDL85567.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Rattus norvegicus] |
| GI:401461794 | GenBank | EDL85568.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Rattus norvegicus] |
| GI:401461794 | RefSeq | XP_006233064.1 | 508 | PREDICTED: hydroxymethylglutaryl-CoA synthase, mitochondrial isoform X1 [Rattus norvegicus] |
Related Sequences to LMP012408 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:401461794 | GenBank | AAH83543.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) [Rattus norvegicus] |
| GI:401461794 | GenBank | EDL85567.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Rattus norvegicus] |
| GI:401461794 | GenBank | EDL85568.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Rattus norvegicus] |