Gene/Proteome Database (LMPD)

LMPD ID
LMP012410
Gene ID
24470
Species
Rattus norvegicus (Rat)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Gene Symbol
Hsd3b5
Synonyms
Hsd1; Hsd3b; RATHSDI;
Alternate Names
3 beta-hydroxysteroid dehydrogenase type 5; 3-beta-HSD V; progesterone reductase; steroid delta-isomerase, 3 beta; 3 beta-hydroxysteroid dehydrogenase 5; 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase;
Chromosome
2
Map Location
2q34
EC Number
1.1.1.-
Summary
catalyzes the conversion of delta 5-3 beta-hydroxysteroids to delta 4-3-ketosteroids in steroid hormone biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hsd3b5

Proteins

3 beta-hydroxysteroid dehydrogenase type 5
Refseq ID NP_036716
Protein GI 6981050
UniProt ID P27364
mRNA ID NM_012584
Length 373
MPGWSCLVTGAGGFLGQRIVQMLVQEKELQEVRVLYRTFSPKHKEELSKLQTKAKVTVLRGDIVDAQFLRRACQGMSVIIHTAAALDIAGFLPRQTILDVNVKGTQLLLDACVEASVPAFIYSSSTGVAGPNSYKETILNDREEEHRESTWSNPYPYSKRMAEKAVLAANGSILKNGGTFHTCALRLPFIYGEESQIISTMVNRALKNNSIIKRHATFSIANPVYVGNAAWAHILAARGLRDPEKSQSIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNRFMVTILNSVFTISYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ

Gene Information

Entrez Gene ID
24470
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Gene Symbol
Hsd3b5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0003854 IDA:RGD F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0051287 IDA:RGD F NAD binding
GO:0005496 IDA:RGD F steroid binding
GO:0016229 TAS:RGD F steroid dehydrogenase activity
GO:0042448 IDA:RGD P progesterone metabolic process
GO:0050810 IDA:RGD P regulation of steroid biosynthetic process
GO:0006694 IDA:RGD P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis
M00107 Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone

REACTOME Pathway Links

REACTOME Pathway ID Description
5953941 Androgen biosynthesis
5953942 Glucocorticoid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953937 Metabolism of steroid hormones and vitamin D
5953936 Mineralocorticoid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Protein Entry
3BHS5_RAT
UniProt ID
P27364
Species
Rat

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxy-Delta(5)-steroid + NADP(+) = 3- oxo-Delta(5)-steroid + NADPH.
Function The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the 3-beta-HSD family
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity Expressed predominantly in male liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012410 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981050 RefSeq NP_036716 373 3 beta-hydroxysteroid dehydrogenase type 5

Identical Sequences to LMP012410 proteins

Reference Database Accession Length Protein Name
GI:6981050 GenBank AAA41352.1 373 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-ene-isomerase [Rattus norvegicus]
GI:6981050 SwissProt P27364.3 373 RecName: Full=3 beta-hydroxysteroid dehydrogenase type 5; AltName: Full=3 beta-hydroxysteroid dehydrogenase type V; Short=3-beta-HSD V; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=Progesterone reductase [Rattus norvegicus]

Related Sequences to LMP012410 proteins

Reference Database Accession Length Protein Name
GI:6981050 GenBank AAA41352.1 373 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-ene-isomerase [Rattus norvegicus]
GI:6981050 GenBank EDL85561.1 373 steroid delta-isomerase, 3 beta [Rattus norvegicus]
GI:6981050 SwissProt P27364.3 373 RecName: Full=3 beta-hydroxysteroid dehydrogenase type 5; AltName: Full=3 beta-hydroxysteroid dehydrogenase type V; Short=3-beta-HSD V; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=Progesterone reductase [Rattus norvegicus]