Gene/Proteome Database (LMPD)

LMPD ID
LMP012411
Gene ID
24513
Species
Rattus norvegicus (Rat)
Gene Name
isovaleryl-CoA dehydrogenase
Gene Symbol
Ivd
Alternate Names
isovaleryl-CoA dehydrogenase, mitochondrial; isovaleryl coenzyme A dehydrogenase;
Chromosome
3
Map Location
3q35
EC Number
1.3.8.4
Summary
is an acyl-CoA dehydrogenase involved in leucine metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ivd

Proteins

isovaleryl-CoA dehydrogenase, mitochondrial precursor
Refseq ID NP_036724
Protein GI 6981112
UniProt ID P12007
mRNA ID NM_012592
Length 424
MATAVRLLGRRVSSWRLRPLPSPLAVPQRAHSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P12007.2) calculated_mol_wt: 3356 peptide sequence: MATAVRLLGRRVSSWRLRPLPSPLAVPQRA mat_peptide: 31..424 product: Isovaleryl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P12007.2) calculated_mol_wt: 43098 peptide sequence: HSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR

Gene Information

Entrez Gene ID
24513
Gene Name
isovaleryl-CoA dehydrogenase
Gene Symbol
Ivd
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:BHF-UCL C mitochondrial matrix
GO:0031966 IDA:BHF-UCL C mitochondrial membrane
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0008470 IDA:BHF-UCL F isovaleryl-CoA dehydrogenase activity
GO:0033539 IC:BHF-UCL P fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0006552 IDA:BHF-UCL P leucine catabolic process
GO:0006551 TAS:RGD P leucine metabolic process
GO:0051260 TAS:RGD P protein homooligomerization

KEGG Pathway Links

KEGG Pathway ID Description
M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA
rno01100 Metabolic pathways
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953282 Branched-chain amino acid catabolism
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
isovaleryl-CoA dehydrogenase
Protein Entry
IVD_RAT
UniProt ID
P12007
Species
Rat

Comments

Comment Type Description
Catalytic Activity Isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Pathway Amino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
Similarity Belongs to the acyl-CoA dehydrogenase family
Subcellular Location Mitochondrion matrix .
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012411 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981112 RefSeq NP_036724 424 isovaleryl-CoA dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012411 proteins

Reference Database Accession Length Protein Name
GI:6981112 GenBank AAA41454.1 424 isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) [Rattus norvegicus]
GI:6981112 GenBank AAH88401.1 424 Isovaleryl coenzyme A dehydrogenase [Rattus norvegicus]
GI:6981112 GenBank EDL79883.1 424 isovaleryl coenzyme A dehydrogenase, isoform CRA_a [Rattus norvegicus]
GI:6981112 SwissProt P12007.2 424 RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012411 proteins

Reference Database Accession Length Protein Name
GI:6981112 GenBank AAA41454.1 424 isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) [Rattus norvegicus]
GI:6981112 GenBank AAH88401.1 424 Isovaleryl coenzyme A dehydrogenase [Rattus norvegicus]
GI:6981112 SwissProt P12007.2 424 RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Rattus norvegicus]