Gene/Proteome Database (LMPD)
LMPD ID
LMP012411
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
isovaleryl-CoA dehydrogenase
Gene Symbol
Alternate Names
isovaleryl-CoA dehydrogenase, mitochondrial; isovaleryl coenzyme A dehydrogenase;
Chromosome
3
Map Location
3q35
EC Number
1.3.8.4
Summary
is an acyl-CoA dehydrogenase involved in leucine metabolism [RGD, Feb 2006]
Orthologs
Proteins
isovaleryl-CoA dehydrogenase, mitochondrial precursor | |
---|---|
Refseq ID | NP_036724 |
Protein GI | 6981112 |
UniProt ID | P12007 |
mRNA ID | NM_012592 |
Length | 424 |
MATAVRLLGRRVSSWRLRPLPSPLAVPQRAHSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR | |
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P12007.2) calculated_mol_wt: 3356 peptide sequence: MATAVRLLGRRVSSWRLRPLPSPLAVPQRA mat_peptide: 31..424 product: Isovaleryl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P12007.2) calculated_mol_wt: 43098 peptide sequence: HSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR |
Gene Information
Entrez Gene ID
Gene Name
isovaleryl-CoA dehydrogenase
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005759 | IDA:BHF-UCL | C | mitochondrial matrix |
GO:0031966 | IDA:BHF-UCL | C | mitochondrial membrane |
GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
GO:0008470 | IDA:BHF-UCL | F | isovaleryl-CoA dehydrogenase activity |
GO:0033539 | IC:BHF-UCL | P | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
GO:0006552 | IDA:BHF-UCL | P | leucine catabolic process |
GO:0006551 | TAS:RGD | P | leucine metabolic process |
GO:0051260 | TAS:RGD | P | protein homooligomerization |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
M00036 | Leucine degradation, leucine => acetoacetate + acetyl-CoA |
rno01100 | Metabolic pathways |
ko00280 | Valine, leucine and isoleucine degradation |
rno00280 | Valine, leucine and isoleucine degradation |
REACTOME Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR006089 | Acyl-CoA dehydrogenase, conserved site |
IPR009075 | Acyl-CoA dehydrogenase/oxidase C-terminal |
IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain |
IPR006091 | Acyl-CoA oxidase/dehydrogenase, central domain |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | Isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein |
Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ; |
Pathway | Amino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. |
Similarity | Belongs to the acyl-CoA dehydrogenase family |
Subcellular Location | Mitochondrion matrix . |
Subunit | Homotetramer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012411 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
6981112 | RefSeq | NP_036724 | 424 | isovaleryl-CoA dehydrogenase, mitochondrial precursor |
Identical Sequences to LMP012411 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:6981112 | GenBank | AAA41454.1 | 424 | isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) [Rattus norvegicus] |
GI:6981112 | GenBank | AAH88401.1 | 424 | Isovaleryl coenzyme A dehydrogenase [Rattus norvegicus] |
GI:6981112 | GenBank | EDL79883.1 | 424 | isovaleryl coenzyme A dehydrogenase, isoform CRA_a [Rattus norvegicus] |
GI:6981112 | SwissProt | P12007.2 | 424 | RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP012411 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:6981112 | GenBank | AAA41454.1 | 424 | isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) [Rattus norvegicus] |
GI:6981112 | GenBank | AAH88401.1 | 424 | Isovaleryl coenzyme A dehydrogenase [Rattus norvegicus] |
GI:6981112 | SwissProt | P12007.2 | 424 | RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Rattus norvegicus] |