Gene/Proteome Database (LMPD)

LMPD ID
LMP012412
Gene ID
24530
Species
Rattus norvegicus (Rat)
Gene Name
lecithin cholesterol acyltransferase
Gene Symbol
Lcat
Alternate Names
phosphatidylcholine-sterol acyltransferase; Lecithin-cholesterol acyltransferase; phospholipid-cholesterol acyltransferase;
Chromosome
19
Map Location
19q12
EC Number
2.3.1.43
Summary
enzyme involved in the metabolism of plasma lipoproteins [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lcat

Proteins

phosphatidylcholine-sterol acyltransferase precursor
Refseq ID NP_058720
Protein GI 158262015
UniProt ID O35849
mRNA ID NM_017024
Length 440
MGLPGSPWQWVLLLLGLLLPPATSFWLLNVLFPPHTTPKAELSNHTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDNTRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVEVYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQAVHLLPMNGTDHLNMVFSNKTLEHINAILLGAYRHGTPKSPTASLGPPTKE
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2560 peptide sequence: MGLPGSPWQWVLLLLGLLLPPATS mat_peptide: 25..440 product: Phosphatidylcholine-sterol acyltransferase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P18424.1) calculated_mol_wt: 47340 peptide sequence: FWLLNVLFPPHTTPKAELSNHTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDNTRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVEVYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQAVHLLPMNGTDHLNMVFSNKTLEHINAILLGAYRHGTPKSPTASLGPPTKE

Gene Information

Entrez Gene ID
24530
Gene Name
lecithin cholesterol acyltransferase
Gene Symbol
Lcat
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0034364 IEA:Ensembl C high-density lipoprotein particle
GO:0004607 IEA:UniProtKB-EC F phosphatidylcholine-sterol O-acyltransferase activity
GO:0034435 IEA:Ensembl P cholesterol esterification
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0008203 IEA:Ensembl P cholesterol metabolic process
GO:0034375 IEA:Ensembl P high-density lipoprotein particle remodeling
GO:0042158 IEA:Ensembl P lipoprotein biosynthetic process
GO:0006656 IEA:Ensembl P phosphatidylcholine biosynthetic process
GO:0090107 IEA:Ensembl P regulation of high-density lipoprotein particle assembly
GO:0043691 IEA:Ensembl P reverse cholesterol transport
GO:0034372 IEA:Ensembl P very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954088 HDL-mediated lipid transport
5953754 Lipid digestion, mobilization, and transport
5953836 Lipoprotein metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
lecithin cholesterol acyltransferase
Protein Entry
O35849_RAT
UniProt ID
O35849
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012412 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158262015 RefSeq NP_058720 440 phosphatidylcholine-sterol acyltransferase precursor

Identical Sequences to LMP012412 proteins

Reference Database Accession Length Protein Name
GI:158262015 GenBank AAB65771.1 440 lecithin:cholesterol acyltransferase [Rattus norvegicus]
GI:158262015 GenBank AAH91155.1 440 Lecithin cholesterol acyltransferase [Rattus norvegicus]
GI:158262015 GenBank EDL92424.1 440 lecithin cholesterol acyltransferase, isoform CRA_b [Rattus norvegicus]
GI:158262015 GenBank AGM78124.1 440 Sequence 3 from patent US 8426358

Related Sequences to LMP012412 proteins

Reference Database Accession Length Protein Name
GI:158262015 GenBank AAH91155.1 440 Lecithin cholesterol acyltransferase [Rattus norvegicus]
GI:158262015 GenBank EDL92424.1 440 lecithin cholesterol acyltransferase, isoform CRA_b [Rattus norvegicus]
GI:158262015 GenBank AGM78124.1 440 Sequence 3 from patent US 8426358