Gene/Proteome Database (LMPD)
LMPD ID
LMP012414
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
lipoprotein lipase
Gene Symbol
Alternate Names
lipoprotein lipase;
Chromosome
16
Map Location
16p14
EC Number
3.1.1.34
Summary
lipase that hydrolyzes triglycerides; may be involved in the development of development of hypertriglyceridemia [RGD, Feb 2006]
Orthologs
Proteins
| lipoprotein lipase precursor | |
|---|---|
| Refseq ID | NP_036730 |
| Protein GI | 6981168 |
| UniProt ID | Q06000 |
| mRNA ID | NM_012598 |
| Length | 474 |
| MESKALLLVALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDWWSSPSFVIEKIRVKAGETQKKVIFCAREKVSHLQKGKDAAVFVKCHDKSLKKSG | |
| sig_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: By similarity; propagated from UniProtKB/Swiss-Prot (Q06000.1) calculated_mol_wt: 2802 peptide sequence: MESKALLLVALGVWLQSLTAFRGGVAA mat_peptide: 28..474 product: Lipoprotein lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q06000.1) calculated_mol_wt: 50298 peptide sequence: ADGGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDWWSSPSFVIEKIRVKAGETQKKVIFCAREKVSHLQKGKDAAVFVKCHDKSLKKSG | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031225 | IEA:UniProtKB-KW | C | anchored component of membrane |
| GO:0009986 | IEA:Ensembl | C | cell surface |
| GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
| GO:0031012 | IDA:RGD | C | extracellular matrix |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0008201 | IEA:UniProtKB-KW | F | heparin binding |
| GO:0004465 | IDA:RGD | F | lipoprotein lipase activity |
| GO:0017129 | IDA:RGD | F | triglyceride binding |
| GO:0016042 | IDA:RGD | P | lipid catabolic process |
| GO:0010886 | IEA:Ensembl | P | positive regulation of cholesterol storage |
| GO:0010744 | IEA:Ensembl | P | positive regulation of macrophage derived foam cell differentiation |
| GO:0010890 | IEA:Ensembl | P | positive regulation of sequestering of triglyceride |
| GO:0009409 | IEP:RGD | P | response to cold |
| GO:0042493 | IEP:RGD | P | response to drug |
| GO:0019432 | IMP:RGD | P | triglyceride biosynthetic process |
| GO:0019433 | IEA:Ensembl | P | triglyceride catabolic process |
| GO:0070328 | IEA:Ensembl | P | triglyceride homeostasis |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko05010 | Alzheimer's disease |
| rno05010 | Alzheimer's disease |
| ko00561 | Glycerolipid metabolism |
| rno00561 | Glycerolipid metabolism |
| ko03320 | PPAR signaling pathway |
| rno03320 | PPAR signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953879 | Chylomicron-mediated lipid transport |
| 5953533 | Developmental Biology |
| 5953253 | Disease |
| 5953382 | Diseases associated with visual transduction |
| 5953754 | Lipid digestion, mobilization, and transport |
| 5953836 | Lipoprotein metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5954392 | Retinoid metabolism and transport |
| 5953381 | Signal Transduction |
| 5954166 | Transcriptional regulation of white adipocyte differentiation |
| 5953380 | Visual phototransduction |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. |
| Function | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) |
| Induction | Induced by insulin. Inhibited by isoproterenol |
| Ptm | Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family |
| Similarity | Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}. |
| Subcellular Location | Cell membrane ; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted . Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity) |
| Subunit | Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012414 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6981168 | RefSeq | NP_036730 | 474 | lipoprotein lipase precursor |
Identical Sequences to LMP012414 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981168 | EMBL | CAL48775.1 | 474 | unnamed protein product [Rattus norvegicus] |
| GI:6981168 | GenBank | EDL75930.1 | 474 | lipoprotein lipase, isoform CRA_a [Rattus norvegicus] |
| GI:6981168 | GenBank | EDL75931.1 | 474 | lipoprotein lipase, isoform CRA_a [Rattus norvegicus] |
| GI:6981168 | GenBank | ACJ92506.1 | 474 | Sequence 14 from patent US 7416851 |
Related Sequences to LMP012414 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981168 | EMBL | CAL48775.1 | 474 | unnamed protein product [Rattus norvegicus] |
| GI:6981168 | GenBank | AAH81836.1 | 474 | Lipoprotein lipase [Rattus norvegicus] |
| GI:6981168 | GenBank | EDL75930.1 | 474 | lipoprotein lipase, isoform CRA_a [Rattus norvegicus] |